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Familial Benign Intracranial Hypertension and Depression

  • C. Edward Coffey (a1), Donald R. Ross (a1), E. Wayne Massey (a1) and C. Warren Olanow (a1)

Summary:

Two sisters developed benign intracranial hypertension (BIH) two weeks following the resolution of a major depressive episode. The association of BIH and a major affective disorder in genetically related individuals has not been previously reported to our knowledge. Both conditions are associated with disturbances in the hypothalamic-pituitary-adrenal axis. Falling corticosteroid levels in a resolving depression may result in impaired cerebrospinal fluid absorption and subsequent BIH.

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Copyright

Corresponding author

Box 31090, Duke University Medical Center, Durham, N.C. 27710, 919-684-8111

References

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