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Erythrocyte Membrane Lipids in Fríedreich's Ataxia

Published online by Cambridge University Press:  18 September 2015

P. Draper ,
Y.S. Huang ,
D. Shapcott ,
B. Lemieux ,
M. Brennan ,
A. Barbeau  and
J. Davignon
P. Draper
Affiliation:
Le Centre Hospitalier Universitaire de l'Université de Sherbrooke and the Clinical Research Institute of Montreal
Y.S. Huang
Affiliation:
Le Centre Hospitalier Universitaire de l'Université de Sherbrooke and the Clinical Research Institute of Montreal
D. Shapcott
Affiliation:
Le Centre Hospitalier Universitaire de l'Université de Sherbrooke and the Clinical Research Institute of Montreal
B. Lemieux
Affiliation:
Le Centre Hospitalier Universitaire de l'Université de Sherbrooke and the Clinical Research Institute of Montreal
M. Brennan
Affiliation:
Le Centre Hospitalier Universitaire de l'Université de Sherbrooke and the Clinical Research Institute of Montreal
A. Barbeau
Affiliation:
Le Centre Hospitalier Universitaire de l'Université de Sherbrooke and the Clinical Research Institute of Montreal
J. Davignon
Affiliation:
Le Centre Hospitalier Universitaire de l'Université de Sherbrooke and the Clinical Research Institute of Montreal
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Summary

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In a study of the lipid composition of erythrocyte membranes in Friedreich's ataxia, the concentration of the major membrane components (phosr pholipids, cholesterol and protein) in ataxie patients, family members, and control subjects were found to be the same. The total fatty acid distribution was also normal. However, an altered distribution of phospholipid classes in erythrocytes was noted (an increase of PI + PS and a decrease of P E in Friedreich's ataxia patients).

Type
Research Article
Information
Canadian Journal of Neurological Sciences , Volume 6 , Issue 2 , May 1979 , pp. 291 - 294
Copyright
Copyright © Canadian Neurological Sciences Federation 1979

References

Bartlett, G. R. (1959). Phosphorus assay in column chromatography. J. Biol. Chem. 234: 466–468.Google ScholarPubMed
Butterfield, D. A., Chesnut, D. B., Roses, A. D. and Appel, S. H. (1974). Electron spin resonance studies oferythrocytes from, patients with myotonic muscular dystrophy. Proc. Nati. Acad. Sci. USA, 71: 909–913.CrossRefGoogle Scholar
Dodge, J. T. and Phillips, G. B. (1967). Composition of phospholipids and of phospholipid fatty acids and aldehydes in human red cells. J. Lipid Res. 8: 667–675.Google ScholarPubMed
Dryer, R. I. (1970). The lipids. In: Fundamentals of Clinical Chemistry (Tietz, N.W., Ed.). W. B. Saunders, Philadelphia, pp. 302–361.Google Scholar
Fairbanks, G., Steck, T. L. and Wallach, D. F. H. (1971). Electrophor-etic analysis of the major polypeptidesof the human erythrocyte membrane. Biochemistry 10: 2606–2617.Google Scholar
Gjone, E., Torsvik, H. and Norum, K. R. (1968). Familial plasma cholesterol ester deficiency: a study of the erythrocytes. Scand. J. Clin. Lab. Invest. 21: 327–332.Google ScholarPubMed
Huang, Y. S., Nestruck, A. C., Barbeau, A., Bouchard, J. P. and Davignon, J. (1978). Plasma lipids and lipoproteins in Fried reich's ataxia. Evidence for abnormal composition of high density lipoproteins. Can. J. Neurol. Sci. 5: 149–156.Google Scholar
Kaloufoutis, A., Jullien, G. and Spanos, V. (1977). Erythrocyte phospholipids in Duchenne Muscular Dystrophy. Clin. Chim. Acta, 74: 85–87.CrossRefGoogle Scholar
Kobayashi, T., Mawatari, S. and Kuroiwa, Y. (1978). Lipids and proteins of erythrocyte membrane in Duchenne Muscular Dystrophy. Clin. Chim. Acta 85: 259–266.Google ScholarPubMed
Kunze, D., Reichmann, G., Egger, E., Leuschner, G. and Eckharat, H. (1973). Erythroztenlipide bei progressiver Muskel Dystrophie. Clin. Chim. Acta 43: 333–341.Google Scholar
Lowry, O. D., Rosebrough, N. J., Farr, A. L. and Randall, R. J. (1951). Protein measurement with the folin phenol reagent. J. Biol. Chem. 193: 265–275.Google ScholarPubMed
Nelson, G. J. (1972). Lipid composition and metabolism of erythrocytes.In: Blood lipids and lipoproteins: Quantitation Composition, and Metabolism (Nelson, G. J., Ed.). Wiley, Interscience, New York, pp. 317–385.Google Scholar
Noel, C., Marcel, Y. L. and Davignon, J. (1972). Plasma phospholipids in the different types of primary hyperlipoprotein-emia. J. Lab. Clin. Med. 79: 611–621.Google Scholar
Roses, A. D., Appel, S. H. (1978). Inherited membrane disorders of muscle: Duchenne Muscular Dystrophy and Myotonic Muscular Dystrophy. In: Physiology of Membrane Disorders (Andreoli, T. E., Hoffman, J. F. and Fanestil, D. D., Eds.). Plenum, New York, pp. 801–815.CrossRefGoogle Scholar
Steinberg, D. (1978). Phytanic acid storage disease: Refsum's Syndrome.In: The Metabolic Basis of Inherited Disease (Stanbury, J. B., Wyngaarden, J. B. and Fredrickson, D. S., Eds.). 4th Edition, McGraw-Hill, New York, pp. 688–706.Google Scholar
Wybenga, D. R. and Inkpen, J. A. (1974). Lipids.In: Clinical Chemistry: Principles and Technics, 2nd Edition. (Henry, R. J., annon, D. C. and Winkelman, J. W., Eds.). Harper and Row, New York, pp. 1421–1493.Google Scholar