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Epidemiological Study of Ruptured Intracranial Aneurysms in the Saguenay-Lac-Saint-Jean region (Quebec, Canada)

  • Jean Mathieu (a1), Louis Pérusse (a2), Pierre Allard (a3), Claude Prévost (a1), Léo Cantin (a1), Jean-Marie Bouchard (a4) and Marc DeBraekeleer (a1)...

Abstract

Background : Using a population-based register of the Saguenay-Lac-Saint-Jean region (Quebec, Canada), the genealogical reconstruction of 533 individuals with intracranial aneurysm (IA) showed a familial aggregation (the presence of aneurysm in two or more first- to third-degree relatives) for 159 (29.8%) of them; this proportion is much higher than reported elsewhere. Objective : As part of an ongoing project to assess a genetic predisposition to intracranial aneurysms in the Saguenay-Lac-Saint-Jean population, the objective of the present study was to determine whether age-specific rates of ruptured cerebral aneurysms were higher than in other populations. Design : A retrospective study of cases of proven ruptured I As which were hospitalized during the 1973 to 1992 period was conducted. Age-adjusted rates were computed and compared to those reported in the Helsinki population. Results : We identified 412 cases of ruptured aneurysms. The age-adjusted incidence rate was 7.2/100,000/year (6.2 for men, 8.1 for women), which is similar to the incidence rates reported in other studies. Although the mean age at time of rupture was younger (46.6 years ± 13.8) than usually reported, no increase in age-specific incidence rates was detected. Conclusions : The results of this epidemiological study neither support nor reject the hypothesis of a genetic predisposition to intracranial aneurysms in the Saguenay-Lac-Saint-Jean population.

Résumé

Étude épidémiologique sur les anévrismes intracrâniens ruptures dans la région du Saguenay-Lac-Saint-Jean (Québec, Canada). Introduction : La reconstruction généalogique de 533 individus atteints d’anévrisme intracrânien (AI), au moyen d’un registre de population de la région du Saguenay-Lac-Saint-Jean (Québec, Canada), a montré une agrégation familiale (la présence d’un anévrisme chez deux cas ou plus qui sont apparentés au premier, deuxième ou troisième degré) chez 159 d’entre eux (29.8%). Cette proportion est bien plus élevée que celle déjà rapportée. Objectif : Cette étude fait partie d’un projet dont le but est d’évaluer la prédisposition génétique aux Aïs dans la population du Saguenay-Lac-Saint-Jean (SLSJ). L’objectif était de déterminer si les taux d’anévrismes cérébraux ruptures ajustés pour l’âge étaient plus élevés que dans les autres populations. Conception : Il s’agit d’une étude rétrospective de cas prouvés d’Aïs ruptures qui ont été hospitalisés entre 1973 et 1992. Les taux ajustés pour l’âge ont été calculés et comparés à ceux rapportés pour la population d’Helsinki. Résultats : Nous avons identifié 412 cas d’anévrismes ruptures. Le taux d’incidence était de 7.2/100,000/année (6.2 pour les hommes, 8.1 pour les femmes), ce qui est semblable aux taux d’incidence rapportés dans d’autres études. Bien que l’âge moyen au moment de la rupture était plus jeune (46.6 13.8 ans) que ce qui est habituellement rapporté, nous n’avons pas noté d’augmentation dans les taux d’incidence selon l’âge. Conclusions : Les résultats de cette étude épidémiologique ne supportent ni ne rejettent l’hypothèse d’une prédisposition génétique aux anévrismes intracrâniens dans la population du SLSJ.

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Copyright

Corresponding author

Unité de recherche clinique. Hôpital de Chicoutimi, 305 Saint-Vallier, Chicoutimi, QC, Canada G7H 5H6

References

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