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Endothelial Progenitor Cells in Patients with Acute Cerebrovascular Ischemia

Published online by Cambridge University Press:  23 September 2016

Askar Mohammad ,
Usman Ghani ,
Brenda Schwindt  and
Ashfaq Shuaib
Askar Mohammad
Affiliation:
Stroke Research Program, University of Alberta, Edmonton, Alberta, Canada
Usman Ghani
Affiliation:
Stroke Research Program, University of Alberta, Edmonton, Alberta, Canada
Brenda Schwindt
Affiliation:
Stroke Research Program, University of Alberta, Edmonton, Alberta, Canada
Ashfaq Shuaib*
Affiliation:
Stroke Research Program, University of Alberta, Edmonton, Alberta, Canada
*
Stroke Research Program, University of Alberta, Edmonton, Alberta, Canada
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Abstract

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Objective:

Statins have been shown to increase endothelial progenitor cells (EPCs) in patients with cardiovascular disease. However, there is no similar study that has been done on the patients recovering from cerebrovascular disease. We present the largest prospective study of statin therapy on EPC levels of patients recovering from stroke.

Method:

Our study subjects were treated with rosuvastatin (10 mg/day) over a period of 12 weeks. Blood was collected from these patients periodically and EPC levels were measured along with other biochemical parameters.

Results and Conclusions:

Our study shows that rosuvastatin treatment significantly reduces the low density lipoprotein (LDL) levels in the patients over the 12 weeks. However, we did not find any corresponding changes in the EPC levels during this time period. Earlier reports indicated that statin use could increase EPC proliferation. Our research, however, indicates that the in-vivo effects of rosuvastatin are not similar to those of previous reports. There may be several reasons for this lack of congruence between these two studies, including age of the study population, predominantly low high density lipoprotein (HDL) levels in our subjects and effects from other concomitant medications.

Résumé

RésuméObjectif:

Il a été démontré que les statines augmentent les cellules progénitrices endothéliales (CPE) chez les patients atteints de maladie cardiovasculaire. Cependant il n'existe pas d'étude similaire chez les patients en phase de récupération d'une maladie cérébrovasculaire. Nous présentons la plus grande étude prospective sur l'effet du traitement par les statines sur le niveau de CPE chez des patients en phase de récupération d'un accident vasculaire cérébral (AVC).

Méthodologie:

Les sujets ont reçu de la rosuvastatine (10 mg par jour) pendant 12 semaines et des prises de sang ont été faites périodiquement. Les niveaux de CPE ainsi que d'autres paramètres biochimiques ont été mesurés.

Résultats et conclusions:

Notre étude démontre que le traitement par la rosuvastatine a diminué significativement le niveau de LDL chez les patients au cours des 12 semaines de traitement. Cependant, nous n'avons pas observé de changement dans le niveau de CPE pendant cette période. Des études antérieures indiquaient que les statines pouvaient augmenter la prolifération des CPE. Cependant, notre étude indique que les effets de la rosuvastatine in vivo ne sont pas similaires à ceux observés dans une étude antérieure. Plusieurs raisons peuvent être invoquées pour expliquer cette divergence entre ces deux études, dont l'âge des sujets étudiés, un taux de HDL généralement bas chez nos sujets et les effets des médicaments concomitants.

Type
Original Articles
Information
Canadian Journal of Neurological Sciences , Volume 37 , Issue 6 , November 2010 , pp. 797 - 802
Copyright
Copyright © The Canadian Journal of Neurological 2010

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