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Effects of Dopamine Denervation on Striatal Peptide Expression in Parkinsonian Monkeys

Published online by Cambridge University Press:  18 September 2015


Brigitte Lavoie
Affiliation:
Centre de recherche en neurobiologie, Université Laval et Hôpital de l'Enfant-Jésus, Québec
André Parent
Affiliation:
Centre de recherche en neurobiologie, Université Laval et Hôpital de l'Enfant-Jésus, Québec
Paul J. Bédard
Affiliation:
Centre de recherche en neurobiologie, Université Laval et Hôpital de l'Enfant-Jésus, Québec

Abstract:

In cynomolgus monkeys rendered parkinsonian by systemic injection of MPTP, severe cell losses were noted in the ventrolateral portion of the substantia nigra pars compacta (SNc), compared to a relative sparing of neurons in the ventral tegmental area (VTA) and dorsomedial portion of SNc. Most spared neurons in the SNc-VTA complex were found to contain the calcium binding protein calbindin (CaBP). At striatal levels the dopaminergic (DA) innervation, as visualized by tyrosine hydroxylase immunoreactivity, was markedly reduced in the ‘sensorimotor’ territory, variably affected in the ‘associative’ territory, and relatively well preserved in the ‘limbic’ territory. The immunoreactivity for enkephalin was enhanced and that for substance P was decreased in the sensorimotor territory, whereas the inverse was observed in the limbic territory. The distribution of the two peptides was highly heterogeneous in the associative territory. These findings suggest that the influence of the DA input on peptide expression varies from one striatal territory to the other, and that CaBP may protect midbrain DA neurons from MPTP toxicity.


Type
Research Article
Copyright
Copyright © Canadian Neurological Sciences Federation 1991

References

1.Agid, Y, Javoy-Agid, F, Ruberg, M.Biochemistry of the neurotrans-mitters in Parkinson’s disease. In: Marsden, CD, Fahn, S: Movement Disorders - 2, Butterworths, London 1987: 166230.Google Scholar
2.Langston, JW, Ballard, P.Chronic Parkinsonism in human due to a product of meperidine-analog synthesis. Nature 1983; 219: 979980.Google ScholarPubMed
3.Burns, RS, Chiueh, CC, Markey, SP, et al. A primate model of parkinsonism: selective destruction of dopaminergic neurons in the pars compacta of the substantia nigra by N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, Proc Natl Acad Sci (USA) 1983; 80: 45464550.CrossRefGoogle ScholarPubMed
4. Langston, JW, Forno, LS, Rebert, CS, et al. Selective nigral toxicity, after systemic administration of 1-methyI-4-phenyl-1,2,5,6-tetrahydropyridine (MPTP) in the squirrel monkey. Brain Res 1984; 292: 390394.CrossRefGoogle ScholarPubMed
5.German, DC, Dubach, M, Askari, S, et al. l-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced parkinsonian syndrome in Macaca fascicularis: which midbrain dopaminergic neurons are lost? Neuroscience 1988; 24: 161174.CrossRefGoogle Scholar
6.Lavoie, B, Parent, A. Immunohistochemical study of the serotonin-ergic innervation of the basal ganglia in the squirrel monkey. J Comp Neurol 1990; 299: 116.CrossRefGoogle Scholar
7.Lavoie, B, Smith, Y, Parent, A. Dopaminergic innervation of the basal ganglia in the squirrel monkey as revealed by tyrosine hydroxylase immunohistochemistry. J Comp Neurol 1989; 288: 3652.CrossRefGoogle Scholar
8.Abercrombie, M. Estimation of nuclear population from microtome sections. Anat Ree 1946; 94: 239244.CrossRefGoogle ScholarPubMed
9. Parent, A. Extrinsic connections of the basal ganglia. Trends in Neuro-science 1990; 13: 254258.CrossRefGoogle ScholarPubMed
10. Parent, A, Lavoie, B, Smith, Y, et al. The dopaminergic nigropallidal projection in primates: Distinct cellular origin and relative sparing in MPTP-treated monkeys. In: Streifler, MB, Korczyn, AD, Melamed, E, Youdim, MBH, eds. Parkinson disease: Anatomy, Pathology and Therapy. Advances in Neurology Vol 53: New York, Raven Press 1990; 111116.Google ScholarPubMed
11.Yamada, T, McGeer, PL, Baimbridge, KG, McGeer, EG. Relative sparing in Parkinson’s disease of substantia nigra dopamine neurons containing calbindin-D28K. Brain Res 1990; 526: 303307.CrossRefGoogle ScholarPubMed

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