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Effect of Alloxan Diabetes on Cerebellar Amino Acids

Published online by Cambridge University Press:  18 September 2015

R. F. Butterworth ,
E. Hamel ,
F. Landreville  and
A. Barbeau
R. F. Butterworth
Affiliation:
Department of Neurobiology, Clinical Research Institute of Montreal
E. Hamel
Affiliation:
Department of Neurobiology, Clinical Research Institute of Montreal
F. Landreville
Affiliation:
Department of Neurobiology, Clinical Research Institute of Montreal
A. Barbeau*
Affiliation:
Department of Neurobiology, Clinical Research Institute of Montreal
*
Clinical Research Institute of Montreal, 110 Pine Avenue West, Montreal, Quebec, Canada, H2W 1R7
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Summary:

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Rats rendered diabetic by alloxan monohydrate were studied to investigate the effect of increased blood glucose upon the concentration of various putative neurotransmitter amino acids in the cerebellum. No modification was found in the concentrations of glutamate, gamma aminobutyric acid (GABA), glutamine, glycine or taurine, but there was a significant decrease in the cerebellar concentration of aspartate in the diabetic animals. This raises the question of the specificity of the aspartic acid defect found in some form of ataxia.

Type
Quebec Cooperative Study of Friedreich's Ataxia
Information
Canadian Journal of Neurological Sciences , Volume 5 , Issue 1 , February 1978 , pp. 135 - 137
Copyright
Copyright © Canadian Neurological Sciences Federation 1978

References

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