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Cucumber Shaped and 35 nm Particles in Creutzfeldt-Jakob Disease

Published online by Cambridge University Press:  18 September 2015

Dikran S. Horoupian  and
R.T. Ross
Dikran S. Horoupian*
Affiliation:
Departments of Pathology and Medicine, Health Sciences Center and Faculty of Medicine, University of Manitoba, Winnipeg, Canada
R.T. Ross
Affiliation:
Departments of Pathology and Medicine, Health Sciences Center and Faculty of Medicine, University of Manitoba, Winnipeg, Canada
*
Department of Pathology, Henry Ford Hospital, 2799 West Grand Blvd., Detroit, Michigan 48202 U.S.A.
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Summary:

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A 63 year old female with the ataxic form of Creutzfeldt-Jakob disease (CJD) is presented. In addition to amyloid plaques which were not associated with Alzheimer’s neurofibrillary tangles, rare profiles similar to those reported in Scrapie were also seen. To our knowledge, these profiles have never been observed in CJD and their presence in this condition adds a further morphologic similarity between the human and animal forms of subacute spongiform “viral” encephalopathies.

Type
Research Article
Information
Canadian Journal of Neurological Sciences , Volume 2 , Issue 3 , August 1975 , pp. 203 - 207
Copyright
Copyright © Canadian Neurological Sciences Federation 1975

References

REFERENCES

Bignami, A. and Parry, H.B. (1972). Electron microscopic studies of the brain of sheep with Natural Scrapie. Brain, 95, Part II, 31926.CrossRefGoogle ScholarPubMed
David-Ferreira, J.F., David-Ferreira, K.L., Gibbs, C.J. Jr., and Morris, J.A. (1968). Scrapie in mice — Ultrastructural observations in the cerebraln cortex. Proc. Soc. Exp. Biol. (N.Y.), 127, 313–20.CrossRefGoogle Scholar
Frazer, H. and Bruce, M. (1973. Argyrophilic plaques in mice inoculated with Scrapie from particular sources. Lancet, 1, 617.CrossRefGoogle Scholar
Field, E.J. and Narang, H.K. (1972). An electron microscopic study of Scrapie in the rat: Further observations on “Inclusion Bodies” and virus-like particles. J. Neurol. Sci., 17, 34764.CrossRefGoogle ScholarPubMed
Gibbs, C.J. Jr. and Gajdusek, D.C. (1972). Amyotrophic lateral sclerosis, Parkinson’s disease and the amyotrophic lateral sclerosis — Parkinsonism dementia complex on Guam: A review and a summary of attempts to demonstrate infection as aetiology. J. Clin. Path., 25 Suppl. (Roy. Coll. Path.), 6, 132–40.CrossRefGoogle Scholar
Gomori, A.J., Partnow, M.J., Horoupian, D.S. and Hirano, A. (1973). The ataxic form of Creutzfeldt- Jakob disease. Arch. Neurol., 29, 318–23.CrossRefGoogle ScholarPubMed
Heefner, W.A. and Sorenson, G.D. (1962). Experimental amyloidosis. I. Light and electron microscopic observations of spleen and lymph nodes. Lab. Invest. 11, 585–93.Google ScholarPubMed
Hirano, A., Ghatak, N.R., Johnson, A.B., Partnow, M.J. and Gomori, A.J. (1972). Argentophilic plaques in Creutzfeldt-Jakob disease. Arch. Neurol. 26, 530–42.CrossRefGoogle ScholarPubMed
Horoupian, D.S., Powers, J.M. and Schaumburg, H.H. (1972). Kuru-like neuropathological changes in a North American. Arch. Neurol. 27, 555–61.CrossRefGoogle Scholar
Horoupian, D.S., Ross, R.T., Gurwith, M.J. and Hoogstraten, J. (1974). Cytoplasmic tubular aggregates and nuclear filamentous bodies in two suspected cases of viral encephalitis. Can. J. Neurol. Sci. 1, 98–105.CrossRefGoogle ScholarPubMed
Lampert, P., Gajdusek, D.C. and Gibbs, C.J. Jr., (1971). Experimental Kuru encephalopathy (Creutzfeldt-Jakob disease) in chimpanzees. Electron microscopic studies. J. Neuropath Exp. Neurol. 30, 20–32.CrossRefGoogle Scholar
Lampert, P.W., Gajdusek, D.C. and Gibbs, C.J. Jr. (1972). Subacute spongiform virus encephalopathies. Am. J. Path. 68, 626–46.Google ScholarPubMed
Narang, H.K., Shenton, B., Giorgi, P.P. and Field, E.J. (1972). Scrapie agent and neurones. Nature, 240, 106–7.CrossRefGoogle ScholarPubMed
Narang, H.K. (1974). Ruthenium Red and Lanthanum nitrate a possible tracer and negative stain for Scrapie “Particles”? Acta Neuropath. (Berl.) 29, 37–43.CrossRefGoogle ScholarPubMed
Norris, F.H. Jr., Aguilar, M.J., Colton, R.P., Oldstone, M.B.A. and Cremer, N.E. (1975). Tubular particles in a case of recurrent lymphocytic meningitis followed by amyotrophic lateral sclerosis – J. Neuropath. Exp. Neurol. 34, 133–47.CrossRefGoogle Scholar
Roos, R., Gajdusek, D.C. and Gibbs, C.J. Jr. (1973). The clinical characteristics of transmissible Creutzfeldt-Jakob disease. Brain, 96, 1–20.Google ScholarPubMed
Terry, R.O., Gonatas, N.K. and Weiss, M. (1964). Ultrastructural studies in Alzheimer’s presenile dementia. Am. J. Path. 44, 269–97.Google ScholarPubMed
Traub, R.D. (1975). Personal communication.Google Scholar
Wisniewski, H., Terry, R.D., and Hirano, A. (1970). Neurofibrillary pathology. J. Neuropath, and Exp. Neurol. 29, 163–76.CrossRefGoogle ScholarPubMed