Hostname: page-component-76fb5796d-5g6vh Total loading time: 0 Render date: 2024-04-25T12:30:01.169Z Has data issue: false hasContentIssue false
  • English
  • Français

The Concurrence of Multiple Sclerosis and Amyotrophic Lateral Sclerosis

Published online by Cambridge University Press:  18 September 2015

Walter J. Hader ,
Bohdan Rozdilsky  and
Cheranada P. Nair
Walter J. Hader*
Affiliation:
Departments of Rehabilitation Medicine, Pathology (Neuropathology), University Hospital, Saskatoon, Saskatchewan and the Plains Health Centre, Regina, Saskatchewan
Bohdan Rozdilsky
Affiliation:
Departments of Rehabilitation Medicine, Pathology (Neuropathology), University Hospital, Saskatoon, Saskatchewan and the Plains Health Centre, Regina, Saskatchewan
Cheranada P. Nair
Affiliation:
Departments of Rehabilitation Medicine, Pathology (Neuropathology), University Hospital, Saskatoon, Saskatchewan and the Plains Health Centre, Regina, Saskatchewan
*
Department of Rehabilitation Medicine, University Hospital, Saskatoon, Saskatchewan, Canada S7N 0X0
Rights & Permissions [Opens in a new window]

Abstract:

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

We report the clinical and pathological findings of the unusual combination of two idiopathic central nervous system diseases, multiple sclerosis and amyotrophic lateral sclerosis in a 56 year old physician with a twenty-seven year history of a disease initially characterized by relapses and remissions, followed by an eight year quiescent period. During the last year of life there was rapid deterioration with development of generalized weakness, atrophy, weight loss and fasciculations of body and tongue, and associated difficulty with swallowing and sudden respiratory failure. The autopsy confirmed characteristic “burned out” plaques of multiple sclerosis and anterior horn cell and axonal degeneration of amyotrophic lateral sclerosis.

Type
Original Articles
Information
Canadian Journal of Neurological Sciences , Volume 13 , Issue 1 , February 1986 , pp. 66 - 69
Copyright
Copyright © Canadian Neurological Sciences Federation 1986

References

REFERENCES

1.Schumacher, GA, Beebe, G, Kibler, RFet al. Problems of experimental trials of therapy in multiple sclerosis. Am MY Acad Sci 1965; 122: 522–568.Google ScholarPubMed
2.Rowland, LP. Diverse Forms of Motor Neuron Diseases. In: Rowland, LP, ed. Advances in neurology. New York: Raven Press, 1982: 1–13.Google Scholar
3.Charcot, JM. Lectures on diseases of nervous system. Translation by Sigerson, G. 2nd edition. Philadelphia: HG Lea, 1879: 164.Google Scholar
4.Pitres, A. Contribution à l’étude des anomalies de la sclérose en plaques disséminée. Rev de med 1877; 1: 893–908.Google Scholar
5.Déjèrine, J. Études sur la sclérose en plaques cerebrospinale à forme de sclérose latéral amyotrophique. Rev de med 1884; 4: 193–212.Google Scholar
6.Bouchaud, . Sclérose en plaques avec amyotrophies. J de neurol 1900; 5: 348–356.Google Scholar
7.Thomas, A, Long, E. Contribution à l’étude des scléroses de la moelle épinière. Comptes Rendus de la société de biologie (Paris) 1899; 2: 768–770.Google Scholar
8.Brauer, L. Muskelatrophie bei MultiplerSklerose. Neurol Centralbl 1898; 17: 635–640.Google Scholar
9.Probst, M. Zur Kenntnis der disseminierten Hirn-Ruckenmarksklerose. Arch f Psychiat 1901; 24: 447–472.Google Scholar
10.Wegelin, F. Ueber akut verlaufende MultiplerSklerose. Deutsche Ztschrf Nervenh 1906: 31: 313–327.CrossRefGoogle Scholar
11.Schnitzler, JG. Klinische Beitrage zur Kenntnis der Muskel-atrophien laufenden formen von multipler sklerose and chronische myelitis. Ztschrf d ges Neurol u Psychiat 1912; 12: 310–353.CrossRefGoogle Scholar
12.Spiller, WG. A report of two cases of multiple sclerosis with necropsy. Am J M Se 1903; 125: 61–74.CrossRefGoogle Scholar
13.Bau-Prussak, S. Uberamyotrophische formder MultiplenSklerose. Zenbralbl f d ges Neurol u Psychiat 1930; 54: 495.Google Scholar
14.Burian, U. Kasuistischer Beitrag zur Frageder psychischen Storungen bei MultiplerSklerose. Bonn 1932.Google Scholar
15.Muller, R. Studies on disseminated sclerosis with special reference to symptomatology, course and prognosis. Acta Med Scand 1949; 133 suppl 222: 1–214.Google Scholar
16.Abb, L, Schaltenbrand, G. Statistische untersuchengen zum problem der Multiplen Sklerose. 11 Mitteilung Das Krankheitsbild der Multiplen Sklerose. Dtsch Z Nervenheilk 1956; 174: 199–218.CrossRefGoogle Scholar
17.Davison, C, Goodhart, SP, Lander, J. Multiple Sclerosis and amyotrophies. Arch Neurol Psychiat (Chic) 1934; 31: 270–289.CrossRefGoogle Scholar
18.Carpenter, S. Proximal axonal enlargement in motor neuron disease. Neurol 1968; 18: 841–851.CrossRefGoogle ScholarPubMed
19.Hanyu, N, Oguchi, K, Yanagisawa, Net al. Degeneration and regeneration of central root motor fibers in amyotrophic lateral sclerosis. Morphometric studies of cervical central roots. J Neurol Sci 1982; 55: 99–115.CrossRefGoogle Scholar
20.Sobue, G, Matsuoka, Y. Mukai, Eet al. Pathology of myelinated fibers in cervical and lumbar ventral spinal roots in amyotrophic lateral sclerosis. J Neurol Sci 1981; 50: 413–421.CrossRefGoogle ScholarPubMed
21.Sobue, G, Hashizume, Y, Sahashi, Ket al. Amyotrophic lateral sclerosis. Lack of central chromatolytic response of motor neurocytons corresponding to active axonal degeneration. Arch Neurol 1983; 40: 306–309.CrossRefGoogle ScholarPubMed
22.Schoene, WC, Carpenter, S, Behan, PO. Geschwind, N. Onion bulb formations in the central and peripheral nervous system in association with multiple sclerosis and hypertrophic polyneuropathy. Brain 1977; 100: 755–773.CrossRefGoogle ScholarPubMed
23.Rosenberg, NL, Bourdette, D. Hypertrophic neuropathy and multiple sclerosis. Neurol 1983; 33: 1361–1364.CrossRefGoogle ScholarPubMed
24.Ro, YI, Alexander, CB, Oh, SJ. Multiple sclerosis and hypertrophic demyelinating peripheral neuropathy. Muscle Nerve 1983; 6: 312–316.Google ScholarPubMed
25.Pollock, M, Calder, C, Allpress, S. Peripheral nerve abnormality in multiple sclerosis. Ann Neurol 1977: 2: 41–48.CrossRefGoogle ScholarPubMed
26.Nagler, B, Beebe, GW, Kurtzke, JFet al. Studies on the natural history of multiple sclerosis. 1. Design and Diagnosis. Acta Neurol Scan 1966: 42: suppl 19: 141–156.CrossRefGoogle ScholarPubMed
27.Thygesen, P. The course of disseminated sclerosis. A close-up of 105 attacks. Copenhagen: Rosenkilde and Bagger, 1953.Google Scholar
28.Kurtzke, JF. Symptomatology of Multiple Sclerosis. In: Vinken, PJ, Brwyn, GM, eds. Handbook of Neurology, Vol.9. North-Holland Amsterdam: American Elseimier NY Publishing Company, 1970: 179–209.Google Scholar
29.McAlpine, D, Lumsden, CE, Acheson, ED. Symptoms and signs in multiple sclerosis. A reappraisal. 2nded. Edinburgh and London: Livingstone. 1972: 140.Google Scholar
30.Paty, DW, Poser, C. Peripheral Nerve Signs and Amyotrophy. In: Poser, C, ed. The diagnosis of multiple sclerosis. Stuttgart, New York: Theime Stratton Inc. 1984: 39–40.Google Scholar
31.Fisher, M, Long, RR, Drachman, DA. Amytrophy in multiple sclerosis: a pseudoneurogenic process. Trans Am Neurol Assoc. 1981: 10: 261–263.Google Scholar
32.Fisher, M, Long, RR, Drachman, DA. Hand muscle atrophy in multiple sclerosis. Arch Neurol 1983; 40: 811–815.CrossRefGoogle ScholarPubMed
33.Mulder, DW. Clinical limits of ALS. In: Rowland, LP, ed. Advances in Neurology. New York: Raven Press. 1982: 15–22.Google Scholar
34.Tyler, HR. Non Familial Amyotrophy. In: Rowland, LP, ed. Advances in Neurology. New York: Raven Press, 1982: 173–180.Google Scholar
35.Mulder, DW, Bushek, W, Spring, Eet al. Motor neuron disease (ALS): evaluation of detection thresholds of cutaneous sensation. Neurology (Cleveland) 1983; 33: 1625–1627.CrossRefGoogle ScholarPubMed
36.Wechsler, IS, Brock, S, Weil, A. Amyotrophic lateral sclerosis with objective and subjective (neuritic) sensory disturbances. Arch Neurol Psychiat 1929; 21: 299–310.CrossRefGoogle Scholar
37.Feller, TG, Jones, RE, Netsky, MG. Amyotrophic lateral sclerosis and sensory changes. Va Med 1966; 93: 328–335.Google ScholarPubMed
38.Noseworthy, JH, Heffernan, LP. Motor radiculopathy — an unusual presentation of multiple sclerosis. Canad J Neurol Sci 1980; 7: 207–209.CrossRefGoogle ScholarPubMed
39.Breland, AE, Currier, RD. Multiple sclerosis and amyotrophic lateral sclerosis in Mississippi. Neurol 1967; 17: 1011–1016.CrossRefGoogle ScholarPubMed
40.Juergens, SM, Kurland, LT, Okazaki, H, Mulder, DW. ALS in Rochester Minnesota, 1925–1977. Neurology 1980; 30: 463–470.CrossRefGoogle ScholarPubMed