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Computed Tomography, Magnetic Resonance Imaging and Pathological Correlations in a Case of Binswanger's Disease

Published online by Cambridge University Press:  18 September 2015

M. Mascalchi ,
D. Inzitari ,
G. Dal Pozzo ,
N. Taverni  and
A.L. Abbamondi
M. Mascalchi*
Affiliation:
Department of Neurology, University of Florence
D. Inzitari
Affiliation:
Department of Neurology, University of Florence
G. Dal Pozzo
Affiliation:
MR Unit, Department of Physiopathology, University of Florence
N. Taverni
Affiliation:
MR Unit, Department of Physiopathology, University of Florence
A.L. Abbamondi
Affiliation:
Department of Neurology, Catholic University, Rome
*
Department of Neurology, University of Florence, Viale Morgagni 85, 50132, Florence Italy
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Abstract:

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The results of 3 computed tomography (CT) examinations carried out over a 7 year period and of a post-mortem magnetic resonance (MR) study showed aspects of a white matter disease in a hypertensive patient suffering from vascular dementia. Histopathology revealed the primary cause of dementia to be a white matter degeneration sparing the U fibers. Rarefaction of both the myelin sheaths and the axons was present together with severe thickening of the medullary arteries. These findings support the existence of Binswanger's disease (BD) as a distinct variety of arteriosclerotic dementia. CT and MR imaging are valuable aids for diagnosis. However, since there are many other causes of CT and MR demonstrated diffuse white matter degeneration in the elderly, a conclusive diagnosis of BD requires pathological confirmation.

Type
Original Articles
Information
Canadian Journal of Neurological Sciences , Volume 16 , Issue 2 , May 1989 , pp. 214 - 218
Copyright
Copyright © Canadian Neurological Sciences Federation 1989

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