Hostname: page-component-8448b6f56d-jr42d Total loading time: 0 Render date: 2024-04-25T04:32:53.729Z Has data issue: false hasContentIssue false
  • English
  • Français

Clobazam for Refractory Childhood Seizure Disorders - A Valuable Supplementary Drug

Published online by Cambridge University Press:  18 September 2015

Robert Munn ,
Peter Camfield ,
Carol Camfield  and
Joseph Dooley
Robert Munn
Affiliation:
Department of Paediatrics, lzaak Walton Killam Hospital for Children, Dalhousie University, Halifax
Peter Camfield*
Affiliation:
Department of Paediatrics, lzaak Walton Killam Hospital for Children, Dalhousie University, Halifax
Carol Camfield
Affiliation:
Department of Paediatrics, lzaak Walton Killam Hospital for Children, Dalhousie University, Halifax
Joseph Dooley
Affiliation:
Department of Paediatrics, lzaak Walton Killam Hospital for Children, Dalhousie University, Halifax
*
Hospital for Children, 5850 University Ave., Halifax, Nova Scotia, Canada B3J 3G9
Rights & Permissions [Opens in a new window]

Abstract:

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

Clobazam is a new benzodiazepine recently introduced in Canada on an experimental basis. We report our experience with 27 children (average age 9.1 years) with severe intractable seizure disorders. All had mixed seizures (41% focal plus generalized, 59% mixed generalized) and 93% were mentally retarded. Eighty-five percent had multiple daily seizures and all had been on an average of 6 other anticonvulsants in the past. Forty-one percent of our patients responded to clobazam with a reduction of greater than 75% in seizure frequency and 15% had no further seizures. Tolerance to clobazam which could not be overcome by dose increases developed in 26% of patients. Fortyfour percent of non-responders had exacerbations of their seizures shortly after starting clobazam, however 43% of these patients had reductions in comedications simultaneously. Side effects of clobazam in responders were minimal. We conclude that clobazam shows sufficient promise to warrant further trials in more benign seizure disorders in children.

Type
Original Articles
Information
Canadian Journal of Neurological Sciences , Volume 15 , Issue 4 , November 1988 , pp. 406 - 408
Copyright
Copyright © Canadian Neurological Sciences Federation 1988

References

REFERENCES

1.Farrell, K.Benzodiazepines in the treatment of children with epilepsy. Epilepsia 1986; 27(Suppl. 1): S45–S51.Google ScholarPubMed
2.Jawad, S, Richens, A, Oxley, J. Single dose pharmacokinetic study of clobazam in normal volunteers and epileptic patients. Br J Clin Pharmacol 1984; 18; 873–7.CrossRefGoogle ScholarPubMed
3.Cano, JP, Bun, H, Iliadis, A, et al. Influence of anti-epileptic drugs on plasma levels of clobazam and desmethylclobazam: application of research on relations between doses, plasma levels and clinical efficacy, In: Hindmarch, I, Stonier, PD, eds. Clobazam International congress and symposium series, no. 43. London: Royal Society of Medicine 1981: 169–174.Google Scholar
4.Fielding, A, Hoffmann, I. Pharmacology of anti-anxiety drugs with special reference to clobazam. Br J Clin Pharmacol 1979; 7: 7S–15S.Google ScholarPubMed
5.Koeppen, D. A review of clobazam studies in epilepsy. In: Hindmarch, I, Stonier, PD, Trimble, MR, eds. Clobazam: Human Psychopharmacology and Clinical Application. International congress and symposium series, no. 74. London: Royal Society of Medicine 1985: 207–15.Google Scholar
6.Tinuper, P, Aguglia, U, Gastaut, H. Use of clobazam in certain forms of status epilepticus and in startle-induced epileptic seizures. Epilepsia 1986; 27(Suppl. 1): S18–S26.CrossRefGoogle ScholarPubMed
7.Gastaut, H, Low, MD. Antiepileptic properties of clobazam a 1,5 benzodiazepine, in man. Epilepsia 1979; 20: 437–46.CrossRefGoogle ScholarPubMed
8.Cull, CA, Trimble, MR. Anticonvulsant benzodiazepines and performance. In: Hindmarch, I, Stonier, PD, Trimble, MR, eds. Clobazam: Human Psychopharmacology and Clinical Application. International congress and symposium series, no. 74. London: Royal Society of Medicine 1985: 121–8.Google Scholar
9.Kruse, HJ. Psychopharmacology of clobazam with special reference to its anticonvulsant activity. In: Hindmarch, I, Stonier, PD, Trimble, MR, eds. Clobazam: Human Psychopharmacology and Clinical Application. International congress and symposium series, no. 74. London: Royal Society of Medicine 1985: 113–20.Google Scholar
10.Robertson, M. Current status of the 1,4 - and 1,5 - benzodiazepines in the treatment of epilepsy: the place of clobazam. Epilepsia 1986; 27(Suppl. 1): S27–S41.CrossRefGoogle Scholar
11.Gastaut, H. The effect of benzodiazepines on chronic epilepsy in man (with particular reference to clobazam). In: Hindmarch, I, Stonier, PD, eds. Clobazam International congress and symposium, no. 43. London: Royal Society of Medicine 1981: 141–150.Google Scholar
12.Schmidt, D, Rohde, M, Wol, P, et al. Clobazam for refractory epilepsy, a controlled trial. Arch Neurol 1986; 43: 824–6.CrossRefGoogle ScholarPubMed
13.Shimizu, H, Abe, J, Futagi, Y, et al. Antiepileptic effects of clobazam in children. Brain Dev 1982; 4: 57–62.CrossRefGoogle ScholarPubMed
14.Dulac, O, Figueroa, D, Rey, E, et al. Monothérapie par le clobazam dans les épilepsies de l’enfant. Presse Méd 1983; 12: 1067–9.Google Scholar