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Cerebral Tissue Response to Electrode Implantation

Published online by Cambridge University Press:  18 September 2015

Ronald F. Dodson ,
L.W-F Chu  and
N. Ishihara
Ronald F. Dodson*
Affiliation:
Department of Experimental Pathology, The University of Texas Health Center at Tyler, Texas 75710. The Baylor-Methodist Center for Cerebrovascular Research and The Department of Pathology, Baylor College of Medicine, Houston, Texas 77030
L.W-F Chu
Affiliation:
Department of Experimental Pathology, The University of Texas Health Center at Tyler, Texas 75710. The Baylor-Methodist Center for Cerebrovascular Research and The Department of Pathology, Baylor College of Medicine, Houston, Texas 77030
N. Ishihara
Affiliation:
Department of Experimental Pathology, The University of Texas Health Center at Tyler, Texas 75710. The Baylor-Methodist Center for Cerebrovascular Research and The Department of Pathology, Baylor College of Medicine, Houston, Texas 77030
*
Departments of Experimental Pathology & Environmental Sciences, University of Texas Health Center, P.O. Box 2003, Tyler, Texas 75710, U.S.A.
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Summary:

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Tissue response to platinum electrodes was assessed after an eight-day implantation period. The regions of study included the cortical areas at the opercular gyri and at the sulcus parielo-occipitalis externus, as well as the sub-cortical white matter in these areas.

Perivascular and intraparenchymal hemorrhagic lesions as well as edematous changes characterized both by extensive intra and extracellular swelling were noted. Numerous phagocytic elements and degenerative structures were present at the electrode I parenchymal interface.

Tissue alterations were asymmetrical as observed both around and at the lip of the implanted electrode. The parenchymal alterations extended from 0.2mm to 3.5mm distance from the electrode path/ parenchymal interface.

Greater tissue involvement was found in the subcortical white matter as compared to the adjacent cortical gray matter.

Type
Research Article
Information
Canadian Journal of Neurological Sciences , Volume 5 , Issue 4 , November 1978 , pp. 443 - 446
Copyright
Copyright © Canadian Neurological Sciences Federation 1978

References

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