Hostname: page-component-76fb5796d-vvkck Total loading time: 0 Render date: 2024-04-25T19:02:06.543Z Has data issue: false hasContentIssue false
  • English
  • Français

Cerebellar Dysfunction of Movement and Perception

Published online by Cambridge University Press:  18 September 2015

H.C. Diener ,
J. Hore ,
R. Ivry  and
J. Dichgans
H.C. Diener*
Affiliation:
Department of Neurology, University of Essen, FRG (HCD), the Department of Physiology, University of Western Ontario, London, Canada (JH), the Department of Psychology, University of California, Berkeley, USA (RI) and the Department of Neurology, University of Tubingen, FRG (JD)
J. Hore*
Affiliation:
Department of Neurology, University of Essen, FRG (HCD), the Department of Physiology, University of Western Ontario, London, Canada (JH), the Department of Psychology, University of California, Berkeley, USA (RI) and the Department of Neurology, University of Tubingen, FRG (JD)
*
Neurologische Universitatsklinik, Hufelandstr. 55, D4300 Essen, FRG
Rights & Permissions [Opens in a new window]

Abstract:

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

This review describes some characteristics of patients with cerebellar lesions, including limb movements, changes in motor planning and disturbances in time-dependent perception. The delay in movement initiation can be explained by a delay in onset of movement-related discharge of neurons in motor cortex. Disorders of movement termination (hypermetria) are accompanied by asymmetric velocity profiles and by prolonged agonist and delayed antagonist EMG activity necessary to brake the movement. During complex movements in three-dimensional space, the cerebellum contributes to timing between single components of a movement, scales the size of muscular action, and coordinates the sequence of agonists and antagonists. The basic structure of motor programs is not generated exclusively within the cerebellum and patients with cerebellar lesions can use precuing information to improve their motor performance. Time-dependent perception in the auditory and visual domains are disturbed in patients with cerebellar lesions.

Type
Abstract
Information
Canadian Journal of Neurological Sciences , Volume 20 , Issue S3 , May 1993 , pp. S62 - S69
Copyright
Copyright © Canadian Neurological Sciences Federation 1993

References

REFERENCES

1.Holmes, G.The symptoms of acute cerebellar injuries due to gunshot injuries. Brain 1917; 40: 461–535.CrossRefGoogle Scholar
2.Holmes, G.Clinical symptoms of cerebellar disease and their inter pretation. The Croonian lectures I. Lancet 1922; 1: 1177–1182.Google Scholar
3.Holmes, G.Clinical symptoms of cerebellar disease and their inter pretation. The Croonian lectures II. Lancet 1922; 1: 1231–1237.Google Scholar
4.Holmes, G.Clinical symptoms of cerebellar disease and their inter pretation. The Croonian lectures III. Lancet 1922; 2:59–65.Google Scholar
5.Holmes, G.Clinical symptoms of cerebellar disease and their inter pretation. The Croonian lectures IV. Lancet 1922; 2: 111–115.Google Scholar
6.Holmes, G.The cerebellum of man. Brain 1939; 62: 1–30.CrossRefGoogle Scholar
7.Dow, RS, Moruzzi, G.The Physiology and Pathology of the Cerebellum. Minneapolis: University of Minnesota Press, 1958.Google Scholar
8.Gilman, S, Bloedel, J, Lechtenberg, R.Disorders of the Cerebellum. Philadelphia: Davis, 1981.Google Scholar
9.Brooks, VB, Thach, WT.Cerebellar control of posture and movement. In: Brookhart, JM, Mountcastle, VB, eds. Handbook of Physiology, Section 1, Volume 2, Part 2, Bethesda: American Physiological Society, 1981: 877–946.Google Scholar
10.Dichgans, J, Diener, HC.Clinical evidence for functional compartmentalization of the cerebellum. In: Bloedel, JR, Dichgans, J, Precht, W, eds. Cerebellar Functions. Berlin Heidelberg: Springer 1984; 126–147.CrossRefGoogle Scholar
11.Ito, M.The Cerebellum and Neural Control. New-York:Raven Press 1984.Google Scholar
12.Marsden, CDMerton, PAMorton, HBet al. Disorders of movement in cerebellar disease in man. In: Rose, FC, ed. Physiological Aspects of Clinical Neurology. Oxford: Blackwell 1977; 179–199.Google Scholar
13.Meyer-Lohmann, J, Hore, J, Brooks, VB.Cerebellar participation in generation of prompt arm movements. J Neurophysiol 1977; 40: 1038–1050.CrossRefGoogle ScholarPubMed
14.Lamarre, Y, Bioulac, B, Jacks, B.Activity of precentral neurons in conscious monkeys: effects of deafferentation and cerebellar ablation. J Physiol (Paris) 1978; 74: 253–264.Google Scholar
15.Lamarre, Y, Jacks, B.Involvement of the cerebellum in the initiation of fast ballistic movement in the monkey. Electroencephalogr Clin Neurophysiol Suppl 1978; 34: 441–447.Google Scholar
16.Miller, AD, Brooks, VB.Parallel pathways for movement initiation in monkeys. Exp Brain Res 1982; 45: 328–332.CrossRefGoogle ScholarPubMed
17.Beaubaton, D, Trouche, E, Legallet, E.Neocerebellum and motor programming: evidence from reaction-time studies in monkeys with dentate nucleus lesions. In: Kornblum, S, Requin, J, eds. Preparatory States & Processes. Lawrence Erlbaum Ass., Pubi. London, Hillsdale New Jersey 1984: 303–320.Google Scholar
18.Hore, J, Wild, B, Diener, HC.Cerebellar dysmetria at the elbow, wrist and fingers. J Neurophysiol 1991; 65: 563–571.CrossRefGoogle ScholarPubMed
19.Wild, B.Schnelle zielgerichtete Bewegungen der oberen Extremität bei Normalpersonen und cerebellären Patienten. Tübingen: M.D. Thesis, 1990.Google Scholar
20.Beppu, H, Suda, M, Tanaka, R.Analysis of cerebellar motor disorders by visually guided elbow tracking movement. Brain 1984; 107: 787–809.CrossRefGoogle ScholarPubMed
21.Spidalieri, G, Busby, L, Lamarre, Y.Fast ballistic arm movements triggered by visual, auditory, and somesthetic stimuli in the monkey. II. Effects of unilateral dentate lesion on discharge of precentral cortical neurons and reaction time. J Neurophysiol 1983; 50: 1359–1379.CrossRefGoogle ScholarPubMed
22.Thach, WT.Timing of activity in cerebellar dentate nucleus and cerebral motor cortex during prompt volitional movement. Brain Res 1975; 88: 233–241.CrossRefGoogle ScholarPubMed
23.Meyer-Lohmann, J, Conrad, B, Matsunami, K, Brooks, VB.Effects of dentate cooling on precentrai unit activity following torque pulse injections into elbow movements. Brain Res 1975; 94: 237–251.CrossRefGoogle ScholarPubMed
24.Hore, J, Flament, D.Changes in motor cortex neural discharge associated with the development of cerebellar limb ataxia. J Neurophysiol 1988; 60: 1285–1302.CrossRefGoogle ScholarPubMed
25.Hallett, M, Berardelli, A, Matheson, J, Rothwell, J, Marsden, CD.Physiological analysis of simple rapid movements in patients with cerebellar deficits. J Neurol Neurosurg Psychiatry 1991; 53: 124–133.CrossRefGoogle Scholar
26.Flament, D, Hore, J.Movement and electromyographic disorders associated with cerebellar dysmetria. J Neurophysiol 1986; 55: 1221–1233.CrossRefGoogle ScholarPubMed
27.Brown, SH, Hefter, H, Mertens, M, Freund, H-J.Disturbances in human arm movement trajectory due to mild cerebellar dysfunction. J Neurol Neurosurg Psychiatry 1990; 53: 306–313.CrossRefGoogle ScholarPubMed
28.Hallett, M, Shahani, BT, Young, RR. EMG analysis of stereotyped voluntary movements in man. J Neurol Neurosurg Psychiatry 1975; 38: 1154–1162.CrossRefGoogle ScholarPubMed
29.Becker, WJ, Kunesch, E, Freund, H-J.Coordination of a multi-joint movement in normal humans and in patients with cerebellar dys-function. Can J Neurol Sci 1990; 17: 264–274.CrossRefGoogle Scholar
30.Babinski, J.De l’asynergie cérébelleuse. Rev Neurol 1899; 7: 806–816.Google Scholar
31.Babinski, J.Sur le rôle du cervelet dans les actes volitionnels neces sitants une succession rapide de mouvements (diadochocinésie). Rev Neurol 1902; 10: 1013–1015.Google Scholar
32.Conrad, B, Brooks, VB.Effects of dentate cooling on rapid alternating arm movements. J Neurophysiol 1974; 37: 792–804.CrossRefGoogle ScholarPubMed
33.Diener, HC, Dichgans, J, Gusehlbauer, B.;, Bacher, M, Rapp, H, Klockgether, T.The coordination of posture and voluntary movement in patients with cerebellar dysfunction. Movement Disorders 1992; 7: 14–22.CrossRefGoogle ScholarPubMed
34.Keele, SW.Movement control in skilled motor performance. Psycholog Bull 1968; 77: 155–158.Google Scholar
35.Inhoff, AW, Diener, HC, Rafal, RD, Ivry, R.The role of cerebellar structures in the execution of serial movements. Brain 1989; 112: 565–581.CrossRefGoogle ScholarPubMed
36.Rosenbaum, DA.The movement precuing technique: assumptions, applications, and extensions In: Magill, RA, ed. Memory and Control of Action. North-Holland Publishing Company, 1983: 23–274.Google Scholar
37.Stelmach, GE, Worringham, CJ, Strand, EA.Movement preparation in Parkinson’s disease: the use of advanced information. Brain 1986; 109: 1179–1194.CrossRefGoogle Scholar
38.Ivry, RB, Keele, SW, Diener, HC.Dissociation of the lateral and medial cerebellum in movement timing and movement execution. Exp Brain Res 1988; 73: 167–180.CrossRefGoogle ScholarPubMed
39.Wing, A, Kristofferson, A.Response delays and the timing of discrete motor responses. Percept Psychophys 1973; 14: 5–12.CrossRefGoogle Scholar
40.Ivry, RB, Keele, SW.Timing functions of the cerebellum. J Cogn Neurosci 1989; 1: 136–152.CrossRefGoogle ScholarPubMed
41.Ivry, RB, Diener, HC.Impaired velocity perception in patients with lesions of the cerebellum. J Cogn Neurosci 1991; 3: 355–366.CrossRefGoogle ScholarPubMed
42.Keele, SW, Ivry, RB.Does the cerebellum provide a common computation for diverse tasks: a timing hypothesis. In: Diamond, A, ed. Developmental and Neural Basis of Higher Cognitive Function. Ann NY Acad Sci 1991; 179–211.Google Scholar