Skip to main content Accessibility help
×
Home

CD226 Gly307Ser Association With Neuromyelitis Optica in Southern Han Chinese

  • Chao Liu (a1), Guansan Wang (a1), Hong Liu (a1), Yue Li (a1), Jin Li (a2), Yongqiang Dai (a2) and Xueqiang Hu (a2)...

Abstract

Background:

Neuromyelitis optica (NMO) and multiple sclerosis (MS) are autoimmune diseases of the central nervous system with complex pathogeneses. NMO was once considered to be a severe variant of MS. There has been more evidence that a non-synonymous exchange (rs763361/Gly307Ser) in the gene for CD226 is linked to several autoimmune diseases including multiple sclerosis (MS). However, no studies have investigated the role of rs763361 in the pathogenesis of NMO.

Objectives:

The goal of our study is to evaluate the role of CD226 Gly307Ser in neuromyelitis optica (NMO) in Southern Han Chinese.

Methods:

Eight-nine NMO patients, 93 relapsing-remitting multiple sclerosis (RRMS) patients, and 122 controls (CTLs) were enrolled. The rs763361 alleles of the subjects were determined by sequencing-based typing.

Results:

The results strongly support that the TT genotypes are associated with NMO but are not significantly correlated with susceptibility for MS.

Conclusions:

CD226 Gly307Ser may correlate with risk of NMO in Southern Han Chinese.

    • Send article to Kindle

      To send this article to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle. Find out more about sending to your Kindle.

      Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

      Find out more about the Kindle Personal Document Service.

      CD226 Gly307Ser Association With Neuromyelitis Optica in Southern Han Chinese
      Available formats
      ×

      Send article to Dropbox

      To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Dropbox.

      CD226 Gly307Ser Association With Neuromyelitis Optica in Southern Han Chinese
      Available formats
      ×

      Send article to Google Drive

      To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Google Drive.

      CD226 Gly307Ser Association With Neuromyelitis Optica in Southern Han Chinese
      Available formats
      ×

Copyright

Corresponding author

Multiple Sclerosis Center, Department of Neurology, The Third Affiliated Hospital of Sun yat-sen University, No.600 Tianhe Road, Guangzhou 510630, Guangdong Province, China. Email: huxueqiangzssy@yahoo.com.cn

References

Hide All
1.Alcina, A, Vandenbroeck, K, Otaegui, D, et al.The autoimmune disease-associated KIF5A, CD226 and SH2B3 gene variants confer susceptibility for multiple sclerosis. Genes Immun. 2010;11(5):43945.
2.Ross, RT, Cheang, M, Landry, G, et al.Herpes zoster and multiple sclerosis. Can J Neurol Sci. 1999;26:2932.
3.Wang, H, Dai, Y, Qiu, W, et al.HLA-DPB1 0501 is associated with susceptibility to anti-aquaporin-4 antibodies positive neuromyelitis optica in southern Han Chinese. J Neuroimmunol. 2011;233(1-2):1814.
4.Lennon, VA, Wingerchuk, DM, Kryzer, TJ, et al.A serum autoantibody marker of neuromyelitis optica: distinction from multiple sclerosis. Lancet. 2004;364:210612.
5.Zipp, F, Windemuth, C, Pankow, H, et al.Multiple sclerosis associated amino acids of polymorphic regions relevant for the HLA antigen binding are confined to HLA-DR2. Hum Immunol. 2000;61(10):102130.
6.Rodrigo, L, Hernández-Lahoz, C, Fuentes, D, et al.Prevalence of celiac disease in multiple sclerosis. BMC Neurol. 2011;7(11):31.
7.Svejgaard, A.The immunogenetics of multiple sclerosis. Immunogenetics. 2008;60(6):27586.
8.Yamasaki, K, Horiuchi, I, Minohara, M, et al.HLA-DPB1*0501 associated optico-spinal multiple sclerosis: clinical, neuroimaging and immunogenetic studies. Brain.1999;122:168996.
9.Matsushita, T, Matsuoka, T, Isobe, N, et al.Association of the HLA-DPB1*0501 allele with antiaquaporin-4 antibody positivity in Japanese patients with idiopathic central nervous system demyelinating disorders. Tissue Antigens. 2009;73:1716.
10.Lundström, W, Greiner, E, Lundmark, F, et al.No influence on disease progression of non-HLA susceptibility genes in MS. J Neuroimmunol. 2011;237(1-2):98100.
11.Fang, L, Isobe, N, Yoshimura, S, et al.For the South Japan Multiple Sclerosis Genetics Consortium. Interleukin-7 receptor alpha gene polymorphism influences multiple sclerosis risk in Asians. Neurology. 2011;76(24):21257.
12.Elishmereni, M, Bachelet, I, Levi-Schaffer, F.DNAM-1: an amplifier of immune responses as a therapeutic target in various disorders. Curr Opin Investig Drugs. 2008;9(5):4916.
13.Hafler, JP, Maier, LM, Cooper, JD, International Multiple Sclerosis Genetics Consortium (IMSGC), et al.CD226 Gly307Ser association with multiple autoimmune diseases. Genes Immun. 2009;10(1):510.
14.International Multiple Sclerosis Genetics Consortium (IMSGC). The expanding genetic overlap between multiple sclerosis and type I diabetes. Genes Immun. 2009;10(1):1114.
15.Du, Y, Tian, L, Shen, LX, Wang, F, et al.Association of the CD226 single nucleotide polymorphism with systemic lupus erythematosus in the Chinese Han population. Tissue Antigens. 2011;77(1):6577.
16.Wieczorek, S, Hoffjan, S, Chan, A, et al.Novel association of the CD226 (DNAM-1) Gly307Ser polymorphism in Wegener’s granulomatosis and confirmation for multiple sclerosis in German patients. Genes Immun. 2009;10(6):5915.
17.Wingerchuk, DM.Neuromyelitis optica. Int MS J. 2006;13:4250.
18.Polman, CH, Reingold, SC, Banwell, B, et al.Diagnostic criteria for multiple sclerosis: 2010 revisions to the McDonald criteria. Ann Neurol. 2011;69:292302.
19.Shibuya, A, Lanier, LL, Phillips, JH. Protein kinase C is involved in the regulation of both signaling and adhesion mediated by DNAX accessory molecule-1 receptor. J Immunol. 1998;161:16716.
20.Shibuya, K, Shirakawa, J, Kameyama, T, et al.CD226 (DNAM-1) is involved in lymphocyte function-associated antigen 1 costimulatory signal for naive T cell differentiation and proliferation. J Exp Med. 2003 Dec 15;198(12):182939.
21.Deshmukh, HA, Maiti, AK, Kim-Howard, XR, et al.Evaluation of 19 autoimmune disease-associated loci with rheumatoid arthritis in a Colombian population: evidence for replication and gene-gene interaction. J Rheumatol. 2011 Sep;38(9):186670.
22.Dieudé, P, Guedj, M, Truchetet, ME, et al.Association of the CD226 Ser(307) variant with systemic sclerosis: evidence of a contribution of costimulation pathways in systemic sclerosis pathogenesis. Arthritis Rheum. 2011 Apr;63(4):1097105.

CD226 Gly307Ser Association With Neuromyelitis Optica in Southern Han Chinese

  • Chao Liu (a1), Guansan Wang (a1), Hong Liu (a1), Yue Li (a1), Jin Li (a2), Yongqiang Dai (a2) and Xueqiang Hu (a2)...

Metrics

Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed