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Beta-Adrenoceptor Modulation in a Case of Pure Autonomic Failure

Published online by Cambridge University Press:  18 September 2015

Sergio Perna ,
Rocco Leone ,
Maria Jussie Farace ,
Vincenzo Brescia-Morra ,
Giuseppe Campanella  and
Gregorio Brevetti
Sergio Perna*
Affiliation:
Department of Medicine and Neurological Clinic, 2nd Medical School, University of Naples, Naples, Italy
Rocco Leone*
Affiliation:
Department of Medicine and Neurological Clinic, 2nd Medical School, University of Naples, Naples, Italy
Maria Jussie Farace*
Affiliation:
Department of Medicine and Neurological Clinic, 2nd Medical School, University of Naples, Naples, Italy
Vincenzo Brescia-Morra*
Affiliation:
Department of Medicine and Neurological Clinic, 2nd Medical School, University of Naples, Naples, Italy
Giuseppe Campanella*
Affiliation:
Department of Medicine and Neurological Clinic, 2nd Medical School, University of Naples, Naples, Italy
Gregorio Brevetti*
Affiliation:
Department of Medicine and Neurological Clinic, 2nd Medical School, University of Naples, Naples, Italy
*
Via Principati 17, 84100 Salerno, Italy
Via Principati 17, 84100 Salerno, Italy
Via Principati 17, 84100 Salerno, Italy
Via Principati 17, 84100 Salerno, Italy
Via Principati 17, 84100 Salerno, Italy
Via Principati 17, 84100 Salerno, Italy
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Abstract:

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In a patient with pure autonomic failure, exercise did not modify beta-adrenoceptor density, probably due to an insufficient increase in plasma catecholamines. Isoproterenol infusion increased the number of beta-adrenoceptor by only 17%. Since in control subjects an increased beta-adrenoceptor level was found, following both physical stress and isoproterenol infusion, we suggest that the lack of increased beta-adrenoceptor levels may contribute to the poor circulatory adjustments observed in autonomic dysfunction during activities involving the sympathetic nervous system.

Type
Articles
Information
Canadian Journal of Neurological Sciences , Volume 19 , Issue 1 , February 1992 , pp. 80 - 83
Copyright
Copyright © Canadian Neurological Sciences Federation 1992

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