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Association of Serum Bilirubin with Stroke Severity and Clinical Outcomes

Published online by Cambridge University Press:  23 September 2014

Tian Xu ,
Jintao Zhang ,
Tan Xu ,
Wenqing Liu ,
Yan Kong  and
Yonghong Zhang
Tian Xu
Affiliation:
Department of Epidemiology, School of Public Health, Medical College of Soochow University, Suzhou, Jiangsu Province
Jintao Zhang
Affiliation:
Department of Neurology, The 88th Hospital of PLA, Tai'an, Shandong Province, China
Tan Xu
Affiliation:
Department of Epidemiology, School of Public Health, Medical College of Soochow University, Suzhou, Jiangsu Province
Wenqing Liu
Affiliation:
Department of Neurology, The 88th Hospital of PLA, Tai'an, Shandong Province, China
Yan Kong
Affiliation:
Department of Neurology, The 88th Hospital of PLA, Tai'an, Shandong Province, China
Yonghong Zhang*
Affiliation:
Department of Epidemiology, School of Public Health, Medical College of Soochow University, Suzhou, Jiangsu Province
*
Department of Epidemiology, School of Public Health, Medical College of Soochow University, 199 Renai Road, Industrial Park District, Suzhou, Jiangsu Province, China, 215123. Email: yhzhang@suda.edu.cn
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Abstract

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Objective:

The aim of the study is to explore the association of serum bilirubin levels with admission severity and short term clinical outcomes among acute ischemic stroke patients.

Methods:

Data were collected from 2361 acute ischemic stroke patients in four hospitals of Shangdong Province during January 2006 and December 2008. National Institutes of Health Stroke Scale (NIHSS) was used to assess admission and discharge severity. NIHSS≥10 at discharge or in-hospital death was defined as short-term clinical outcomes. Logistic regression and trend test were used to examine the association of serum bilirubin levels with admission severity and short term clinical outcomes.

Results:

Serum bilirubin levels were significantly and positively associated with admission severity (P for trend <0.05). The age-sex adjusted odds ratios (95% confidential intervals) of NIHSS≥10 associated with the second, third and fourth quartile of total bilirubin/direct bilirubin were 1.245 (0.873, 1.777)/1.276 (0.895, 1.818), 1.484 (1.048, 2.102)/1.628 (1.158, 2.289) and 2.869 (2.076, 3.966)/2.765 (1.996, 3.828), respectively, compared with the lowest quartile; the multivariate adjusted odds ratios of NIHSS≥10 associated with the second, third and fourth quartile of total bilirubin/direct bilirubin were 1.088(0.711, 1.665)/1.436(0.94, 2.193), 1.328(0.877, 2.011)/1.647(1.092, 2.485) and 2.336(1.579, 3.458)/3.079 (2.049, 4.623), respectively, compared with the lowest quartile. However, no association between serum bilirubin levels and short-term clinical outcomes was observed in our study.

Conclusion:

Serum bilirubin levels were associated with initial stroke severity closely. Nevertheless, there is no significant relationship between serum bilirubin levels and short-term clinical outcomes among acute ischemic stroke patients.

Type
Original Article
Information
Canadian Journal of Neurological Sciences , Volume 40 , Issue 1 , January 2013 , pp. 80 - 84
Copyright
Copyright © The Canadian Journal of Neurological 2013

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