Hostname: page-component-77c89778f8-gq7q9 Total loading time: 0 Render date: 2024-07-23T03:49:55.506Z Has data issue: false hasContentIssue false
  • English
  • Français

Amyotrophic Lateral Sclerosis/Parkinsonism/Dementia: Clinico-Pathological Correlations Relevant to Guamanian ALS/PD

Published online by Cambridge University Press:  18 September 2015

Arthur J. Hudson
Arthur J. Hudson*
Affiliation:
Department of Clinical Neurological Sciencies, University of Western Ontario, London
*
University Hospital, 339 Windermere Road, London, Ontario, Canada N6A 5A5
Rights & Permissions [Opens in a new window]

Abstract:

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

In a recent report on the clinical and pathological features of Guamanian ALS/PD and post-encephalitic parkinsonism/ALS a number of similarities were described, notably in the distribution of neurofibrillary tangles throughout the nervous system. In this account additional pathological features which these disorders share (and which differ from classical ALS, Parkinson's and Alzheimer's diseases) are described. These include atrophy of the globus pallidus and the entire substantia nigra, viz. pars compacta and pars reticulata. Moreover, neither Lewy bodies nor senile plaques are features of the Guamanian and post-encephalitic disorders. The significance of these observations and their relationship, more generally, to parkinsonism, ALS and dementia are discussed.

Type
Research Article
Information
Canadian Journal of Neurological Sciences , Volume 18 , Issue S3 , August 1991 , pp. 387 - 389
Copyright
Copyright © Canadian Neurological Sciences Federation 1991

References

REFERENCES

1.Hudson, AJ, Rice, GPA. Similarities of Guamanian ALS/PD to post-encephalitic parkinsonism/ALS: possible viral cause. Can J Neurol Sci 1990; 17: 427–433.CrossRefGoogle ScholarPubMed
2.Hirano, A, Kurland, LT, Krooth, RS, et al. Parkinsonism-dementia complex, an endemic disease on the island of Guam. I. Clinical features. Brain 1961; 84: 642–661.CrossRefGoogle ScholarPubMed
3.Hirano, A, Malamud, N, Kurland, LT. Parkinsonism-dementia complex, endemic disease on the island of Guam. II. Pathological features. Brain 1961; 84: 662–679.Google Scholar
4.Matheson Commission. Epidemic encephalitis; etiology, epidemiology, treatment. New York: Columbia University Press, 1929; 179–399.Google Scholar
5.von Economo, C. Encephalitis lethargica: its sequelae and treatment. London: Oxford University Press, 1931.Google Scholar
6.Hudson, AJ. Amyotrophic lateral sclerosis: clinical evidence for differences in pathogenesis and etiology. In Hudson, AJ, ed. Amyotrophic Lateral Sclerosis: Concepts in Pathogenesis and Etiology. Toronto: University of Toronto Press, 1990; 108–143.Google Scholar
7.Hirano, A, Hirano, M, Dembitzer, HM. Pathological variations and extent of the disease process in amyotrophic lateral sclerosis. In: Hudson, AJ, ed. Amyotrophic Lateral Sclerosis: Concepts in Pathogenesis and Etiology. Toronto: University of Toronto Press, 1990; 166–192.Google Scholar
8.Hirano, A, Zimmerman, HM. Alzheimer’s neurofibrillary changes: a topographic study. Arch Neurol 1962; 7: 227–242.CrossRefGoogle ScholarPubMed
9.Alvord, EC, Forno, LS. Pathology. In: Koller, WC, ed. Handbook of Parkinson’s Disease. New York: Marcel Dekker, Inc., 1987; 209–236.Google Scholar
10.Kalus, P, Braak, H, Braak, E, et al.The presubicular region in Alzheimer’s disease: topography of amyloid deposits and neurofibrillary changes. Brain Res 1989; 494: 198–203.CrossRefGoogle ScholarPubMed
11.Pakkenberg, H, Bottcher, J. Corpus striatum in paralysis agitans and perphenazine-injected rats. In: McDowell, FH, Barbeau, A, ed. Second Canadian-American Conference on Parkinson’s Disease. Advances in Neurology. New York: Raven Press, 1974; 5: 203–209.Google Scholar
12.Greenfield, JG, Bosanquet, FD. The brain-stem lesions in parkinsonism. J Neurol Neurosurg Psychiatry. 1953; 16: 213–226.CrossRefGoogle ScholarPubMed
13.Heyman, A, Wikinson, WE, Hurwitz, BJ, et al. Alzheimer’s disease: genetic aspects and associated clinical disorders. Ann Neurol 1983; 14: 507–515.CrossRefGoogle ScholarPubMed
14.Ditter, SM, Mirra, SS. Neuropathologic and clinical features of Parkinson’s disease in Alzheimer’s disease patients. Neurology 1987; 37: 754–760.CrossRefGoogle ScholarPubMed
15.Maurizi, CP. Was a neurovirulent influenza virus the cause of amyotrophic lateral sclerosis and parkinsonism-dementia on Guam? Medical Hypotheses 1987; 23: 325–326.CrossRefGoogle ScholarPubMed