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Altered Gene Expression in Alzheimer's Disease Brain Tissue

Published online by Cambridge University Press:  18 September 2015

Patrick C. May*
Affiliation:
Andrus Gerontology Center and Department of Biological Sciences, University of Southern California, Los Angeles
Steven A. Johnson
Affiliation:
Andrus Gerontology Center and Department of Biological Sciences, University of Southern California, Los Angeles
Judes Poirier
Affiliation:
Andrus Gerontology Center and Department of Biological Sciences, University of Southern California, Los Angeles
Martha Lampert-Etchells
Affiliation:
Andrus Gerontology Center and Department of Biological Sciences, University of Southern California, Los Angeles
Caleb E. Finch
Affiliation:
Andrus Gerontology Center and Department of Biological Sciences, University of Southern California, Los Angeles
*
Andrus Gerontology Center, University of Southern California, Los Angeles, CA, U.S.A. 90089-0191
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Abstract:

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We review the evidence for altered gene expression in Alzheimer's disease brain and identify alternative molecular approaches for isolating additional novel markers. One marker, pADHC-9, was isolated from a human hippocampal cDNA library by differential screening with AD and control cDNA probes. This clone hybridizes to a 2 Kb RNA which is increased 2 fold in AD hippocampus. The deduced amino acid sequence of pADHC-9 codes for a 52 kDAL protein similar to a testicular sulfated glycoprotein secreted by rat Sertoli cells. The normal function of this protein in brain and whether that function is altered in Alzheimer's disease is unknown.

Type
Research Article
Copyright
Copyright © Canadian Neurological Sciences Federation 1989

References

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