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Advances in Experimental and Clinical Studies of Chemotaxis

Published online by Cambridge University Press:  23 September 2014

Aikeremujiang Muheremu ,
Yu Wang  and
Jiang Peng
Aikeremujiang Muheremu
Affiliation:
Institute Of Orthopaedics, Chinese PLA General Hospital, Fifth Affiliated Hospital of Xinjiang Medical University, Beijing, China
Yu Wang
Affiliation:
Institute Of Orthopaedics, Chinese PLA General Hospital, Fifth Affiliated Hospital of Xinjiang Medical University, Beijing, China
Jiang Peng*
Affiliation:
Institute Of Orthopaedics, Chinese PLA General Hospital, Fifth Affiliated Hospital of Xinjiang Medical University, Beijing, China
*
Institute of Orthopaedics, Chinese PLA General Hospital, NO28, Fuxing Rd, Haidian district, Beijing, China. Postal Code: 0086- 100853. Email: pengjdxx@126.com.
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Abstract

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The theory of chemotaxis has been widely accepted, but its mechanisms are disputed. Chemotactic growth of peripheral nerves may be tissue, topographic and end-organ specific. Recent studies indicated that peripheral nerve regeneration lacks topographic specificity, but whether it has end-organ specificity is disputed. Chemotaxis in nerve regeneration is affected by the distance between stumps, volume, and neurotrophic support, as well as the structure of distal nerve stumps. It can be applied to achieve precise repair of nerves and complete recovery of end organ function. Small gap sleeve bridging technique, which is based on this theory shows promising effects but it is still challenging to find the perfect combination of nerve conduits, cells and neurotrophic factors to put it intoits best use. In this paper, we made a comprehensive review of mechanisms, effect factors and applications of chemotaxis.

Résumé:

Résumé:

La théorie de la chimiotaxie est couramment acceptée, mais ses mécanismes demeurent controversés. La croissance chimiotaxique des nerfs périphériques pourrait être spécifique selon les tissus, la topographie et l'organe-cible. des études récentes indiquent une absence de spécificité topographique dans la régénérescence des nerfs périphériques. Cependant la spécificité concernant les organes-cibles demeure controversée. La chimiotaxie dans la régénérescence nerveuse est influencée par la distance entre les extrémités du nerf, le volume et le support neurotrope ainsi que la structure des extrémités nerveuses distales. La chimiotaxie peut être utilisée pour réaliser une réparation précise de nerfs et pour obtenir une récupération de la fonction de l'organe-cible. Une technique de relais par manchon de petits écarts basée sur cette théorie a semblé avoir des effets prometteurs, mais trouver la combinaison parfaite de conduits nerveux, de facteurs cellulaires et neurotropes pour optimiser son utilisation constitue encore un défi. dans cet article, nous faisons un examen approfondi des mécanismes de la chimiotaxie, des facteurs qui l'influencent et de ses applications.

Type
Review Article
Information
Canadian Journal of Neurological Sciences , Volume 40 , Issue 3 , May 2013 , pp. 292 - 298
Copyright
Copyright © The Canadian Journal of Neurological 2013

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