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Absence of Responses to Microstimulation at the Hand-Face Border in Baboon Primary Motor Cortex

Published online by Cambridge University Press:  18 September 2015

Donald D. Samulack ,
Robert S. Waters ,
Robert W. Dykes  and
Patricia A. McKinley
Donald D. Samulack
Affiliation:
Department of Physiology, McGill University, Montreal
Robert S. Waters*
Affiliation:
Department of Anatomy and Neurobiology, The University of Tennessee, Memphis
Robert W. Dykes
Affiliation:
Department of Physiology, McGill University, Montreal
Patricia A. McKinley
Affiliation:
Department of Physical and Occupational Therapy, McGill University, Montreal
*
Department of Anatomy and Neurobiology, The University of Tennessee, Memphis, 875 Monroe Avenue, Memphis, Tennessee, U.S.A. 38163
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Abstract:

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Intracortical microstimulation (ICMS) was used to map the primary motor cortex of four adult female baboons, anesthetized with a mixture of halothane and nitrous oxide and supplemented with sodium pentobarbital. The sequence of observed muscle contractions in response to ICMS provided evidence of an orderly mototopic representation of the tongue, face, hand, forearm and upper body. A zone of cortex unresponsive to microstimulation was consistently observed at the border between the face and hand representation of the mototopic map. This zone was observed in all four animals and was consistent over time. Repeated confirmations of the unresponsive nature of these regions were obtained both early and late in the same experiment. No motor-unit responses or muscle contractions were detected by electromyographic (EMG) recording during stimulation of the unresponsive zones. The absence of both visually observed and EMG-recorded contractions and the fact that muscle contractions could be elicited from adjacent regions of cortex with ICMS as low as 1-5 μA provide compelling evidence that the finding reflects a true physiological condition rather than an experimental artifact.

Type
Original Articles
Information
Canadian Journal of Neurological Sciences , Volume 17 , Issue 1 , February 1990 , pp. 24 - 29
Copyright
Copyright © Canadian Neurological Sciences Federation 1990

References

REFERENCES

1.Fritsch, G, Hitzig, E. Uber die elektdrische Erregarkeit des Grosshirns. Arch Anat Physiol Wiss Med 1870; 37: 300–332. (Translation by von Bonin, G.In: Nowinski, WW, ed. The Cerebral Cortex. Springfield, IL: Thomas 1960; 73–96.)Google Scholar
2.Woolsey, CN. Organization of somatic sensory and motor areas of the cerebral cortex. In: Harlow, HF, Woolsey, CF, eds. Biological and Biochemical Bases of Behavior. Madison: Univ. of Wisconsin Press 1958; 63–81.Google Scholar
3.Asanuma, H, Sakata, H. Functional organization of a cortical efferent zone examined with focal depth stimulation in cat. J Neurophysiol 1967; 30: 35–54.CrossRefGoogle Scholar
4.Stoney, SD Jr, Thompson, WD, Asanuma, H. Excitation of pyramidal tract cells by intracortical microstimulation: effective extent of stimulating current. J Neurophysiol 1968; 31: 659–669.CrossRefGoogle ScholarPubMed
5.Asanuma, H, Rosen, I. Topographical organization of cortical efferent zones projecting to distal forelimb muscles in the monkey. Exp Brain Res 1972; 14: 243–256.CrossRefGoogle ScholarPubMed
6.Huang, CS, Sirisko, MA, Hiraba, H, et al. Organization of the primate face motor cortex as revealed by intracortical microstimulation and electrophysiological identification of afferent inputs and corticobulbar projections. J Neurophysiol 1988; 59: 796–818.CrossRefGoogle ScholarPubMed
7.Kwan, HC, MacKay, WA, Murphy, JT, et al. An intracortical microstimulation study of output organization in precentral cortex of awake primates. J Physiol (Paris) 1978a; 74: 231–233.Google Scholar
8.Kwan, HC, MacKay, WA, Murphy, JT, et al. Spatial organization of precentral cortex in awake primates. II. Motor outputs. J Neurophysiol 1978b; 41: 1120–1131.CrossRefGoogle ScholarPubMed
9.Kwan, HC, Murphy, JT, Wong, YC. Interaction between neurons in precentral cortical zones controlling different joints. Brain Res 1987; 400: 259–269.CrossRefGoogle ScholarPubMed
10.Gould, HJ III, Cusick, CG, Pons, TP, et al. The relationship of corpus callosum connections to electrical stimulation maps of motor, supplementary motor, and the frontal eye fields in owl monkeys. J Comp Neurol 1986; 247: 297–325.CrossRefGoogle ScholarPubMed
11.Neafsey, EJ, Bold, EL, Sievert, CF, et al. The primary motor cortex of the owl monkey: a microstimulation mapping study of the leg and arm areas. Neurosci Abstr 1983; 9: 492.Google Scholar
12.Strick, PL, Preston, JB. Two representations of the hand in area 4 of primate: I. Motor output organization. J Neurophysiol 1982; 48: 139–149.CrossRefGoogle ScholarPubMed
13.Sessle, BJ, Wiesendanger, M. Structural and functional definition of the motor cortex in the monkey (Macaca fascicularis). J Physiol 1982; 323: 245–265.CrossRefGoogle ScholarPubMed
14.McGuinness, E, Sivertsen, D, Allman, JM. Organization of the face representation in macaque motor cortex. J Comp Neurol 1980; 193: 591–608.CrossRefGoogle ScholarPubMed
15.Donoghue, JP, Wise, SP. The motor cortex of the rat: cytoarchitecture and microstimulation mapping. J Comp Neurol 1982; 212: 76–88.CrossRefGoogle ScholarPubMed
16.Neafsey, EJ, Bold, EL, Haas, G, et al. The organization of the rat motor cortex: a microstimulation mapping study. Brain Res Rev 1986; 2: 77–96.CrossRefGoogle Scholar
17.Waters, RS, Asanuma, H. Low threshold motor output from parietal cortex, areas 5a and 5b, of the cat. Exp Brain Res 1983; 50: 459–463.Google Scholar
18.Samulack, DD, Waters, RS, Dykes, RW, et al. Silent zones as a consistent and integral component of the mototopic organization of baboon motor cortex. Soc Neurosci 1987; 13: 241.Google Scholar
19.Leyton, ASF, Sherrington, CS. Observations on the excitable cortex of the chimpanzee, orang-utan and gorilla. Q J Exp Physiol 1917; 2: 135–222.CrossRefGoogle Scholar
20.Asanuma, H, Arnold, AP. Noxious effects of excessive currents used for intracortical microstimulation. Brain Res 1975; 96: 103–107.CrossRefGoogle ScholarPubMed
21.Hines, M. The “motor” cortex. Bull Johns Hopkins Hosp 1937; 60: 313–336.Google Scholar
22.Dusser de Barenne, JG, McCulloch, WS. Suppression of motor response obtained from area 4 stimulation of area 4s. J Neurophysiol 1941; 4: 311–323.CrossRefGoogle Scholar