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Abnormal Proximal Axons of Clarke’s Neurons In Sporadic Motor Neuron Disease

Published online by Cambridge University Press:  18 September 2015

P. Averback*
Affiliation:
Department of Pathology, University of Cambridge, Cambridge, England
P. Crocker*
Affiliation:
Department of Pathology, University of Cambridge, Cambridge, England
*
Department of Pathology, 3775 University Street, Montreal, PQ, H3A 2B4, Canada
Department of Pathology, 3775 University Street, Montreal, PQ, H3A 2B4, Canada
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Filamentous axonalmasses, similar to the abnormal enlargements found in the ventral horns, were found in Clarke’s nucleus in six cases of sporadic A LS. Clarke’s nucleus is generally thought to be normal in sporadic A LS, but the present findings, in conjunction with distal spinocerebellar degeneration which is often described, suggest that this system is also pathologically involved.

Type
Articles
Copyright
Copyright © Canadian Neurological Sciences Federation 1981

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