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Yogurt consumption and colorectal polyps

  • Samara B. Rifkin (a1), Francis M. Giardiello (a2) (a3) (a4), Xiangzhu Zhu (a5), Linda M. Hylind (a2), Reid M. Ness (a6) (a7), Julia L. Drewes (a7) (a8), Harvey J. Murff (a7), Emma H. Spence (a8) (a9), Walter E. Smalley (a10), Joell J. Gills (a8) (a11), Gerard E. Mullin (a2), David Kafonek (a2) (a12), Louis La Luna (a13), Wei Zheng (a5) (a10), Cynthia L. Sears (a2) (a3) (a8) (a9) (a11), Martha J. Shrubsole (a5) (a10) and the Biofilm Study Consortium...

Abstract

Diet modifies the risk of colorectal cancer (CRC) and inconclusive evidence suggests yogurt may protect against CRC. We analyzed data collected from two separate colonoscopy-based case-control studies. The Tennessee Colorectal Polyp Study (TCPS) and Johns Hopkins Biofilm Study included 5446 and 1061 participants, respectively, diagnosed with hyperplastic polyp (HP), sessile serrated polyp (SSP), adenomatous polyp (AP), or without any polyps. Multinomial logistic regression models were used to derive OR and 95 % CI to evaluate comparisons between cases and polyp-free controls and case-case comparisons between different polyp types. We evaluated the association between frequency of yogurt intake and probiotic use with the diagnosis of colorectal polyps. In the TCPS, daily yogurt intake v. no/rare intake was associated with decreased odds of HP (OR 0·54; 95 % CI 0·31, 0·95) and weekly yogurt intake was associated with decreased odds of AP among women (OR 0·73; 95 % CI 0·55, 0·98). In the Biofilm study, both weekly yogurt intake and probiotic use were associated with a non-significant reduction in odds of overall AP (OR 0·75; 95 % CI 0·54, 1·04) and (OR 0·72; 95 % CI 0·49, 1·06) in comparison to no use, respectively. In summary, yogurt intake may be associated with decreased odds of HP and AP and probiotic use may be associated with decreased odds of AP. Further prospective studies are needed to verify these associations.

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Copyright

Corresponding author

*Corresponding author: Martha J. Shrubsole, email martha.shrubsole@vanderbilt.edu

Footnotes

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David Cromwell (Johns Hopkins University School of Medicine and Green Spring Station Endoscopy, Lutherville, MD), Marshall Bedine (Johns Hopkins University School of Medicine and Green Spring Station Endoscopy, Lutherville, MD), Eduardo Gonzalez-Velez (Johns Hopkins University School of Medicine, Baltimore, MD), Hazel Marie Galon Veloso (Johns Hopkins University School of Medicine, Baltimore, MD), Madison McMann (Johns Hopkins University School of Medicine, Baltimore, MD), Courtney Stevens (Johns Hopkins University School of Medicine, Baltimore, MD), Pamela Schearer (Reading Hospital, Tower Health, Reading, PA), Stacy Gerhart (Reading Hospital, Tower Health, Reading, PA), Amy Schiller (Digestive Disease Associates, Reading, Wyomissing, PA), Karin Donato (Digestive Disease Associates, Reading, Wyomissing, PA), John Altomare (Digestive Disease Associates, Reading, Wyomissing, PA), Nirav Shah (Digestive Disease Associates, Reading, Wyomissing, PA), Christopher Ibrahim (Digestive Disease Associates, Reading, Wyomissing, PA), Ravi Ghanta (Digestive Disease Associates, Reading, Wyomissing, PA), Brent Tabisz (Johns Hopkins University School of Medicine, Baltimore, MD), Louis Levine (Johns Hopkins University School of Medicine, Baltimore, MD).

Footnotes

References

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David Cromwell (Johns Hopkins University School of Medicine and Green Spring Station Endoscopy, Lutherville, MD), Marshall Bedine (Johns Hopkins University School of Medicine and Green Spring Station Endoscopy, Lutherville, MD), Eduardo Gonzalez-Velez (Johns Hopkins University School of Medicine, Baltimore, MD), Hazel Marie Galon Veloso (Johns Hopkins University School of Medicine, Baltimore, MD), Madison McMann (Johns Hopkins University School of Medicine, Baltimore, MD), Courtney Stevens (Johns Hopkins University School of Medicine, Baltimore, MD), Pamela Schearer (Reading Hospital, Tower Health, Reading, PA), Stacy Gerhart (Reading Hospital, Tower Health, Reading, PA), Amy Schiller (Digestive Disease Associates, Reading, Wyomissing, PA), Karin Donato (Digestive Disease Associates, Reading, Wyomissing, PA), John Altomare (Digestive Disease Associates, Reading, Wyomissing, PA), Nirav Shah (Digestive Disease Associates, Reading, Wyomissing, PA), Christopher Ibrahim (Digestive Disease Associates, Reading, Wyomissing, PA), Ravi Ghanta (Digestive Disease Associates, Reading, Wyomissing, PA), Brent Tabisz (Johns Hopkins University School of Medicine, Baltimore, MD), Louis Levine (Johns Hopkins University School of Medicine, Baltimore, MD).

Keywords

Yogurt consumption and colorectal polyps

  • Samara B. Rifkin (a1), Francis M. Giardiello (a2) (a3) (a4), Xiangzhu Zhu (a5), Linda M. Hylind (a2), Reid M. Ness (a6) (a7), Julia L. Drewes (a7) (a8), Harvey J. Murff (a7), Emma H. Spence (a8) (a9), Walter E. Smalley (a10), Joell J. Gills (a8) (a11), Gerard E. Mullin (a2), David Kafonek (a2) (a12), Louis La Luna (a13), Wei Zheng (a5) (a10), Cynthia L. Sears (a2) (a3) (a8) (a9) (a11), Martha J. Shrubsole (a5) (a10) and the Biofilm Study Consortium...

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