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Vitamin B12 metabolism in the fruit bat (Rousettus aegyptiacus). The induction of vitamin B12 deficiency and its effect on folate levels.

Published online by Cambridge University Press:  09 March 2007

Susan V. van Tonder ,
J. Metz  and
R. Green
Susan V. van Tonder
Affiliation:
Department of Haernatology, School of Pathology, University of the Witwatersrand and South African Institute for Medical Research, PO Box 1038, Johannesburg 2000, South Africa
J. Metz
Affiliation:
Department of Haernatology, School of Pathology, University of the Witwatersrand and South African Institute for Medical Research, PO Box 1038, Johannesburg 2000, South Africa
R. Green
Affiliation:
Department of Haernatology, School of Pathology, University of the Witwatersrand and South African Institute for Medical Research, PO Box 1038, Johannesburg 2000, South Africa
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Abstract

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1. Vitamin B12 metabolism was studied in bats of the species Rousettus aegyptiacus, which live on an all-fruit diet in the wild.

2. There was a wide range in values for the serum vitamin B12 concentration of newly captured bats, but bats captured in the early spring had significantly higher mean serum vitamin B12 levels than bats captured in the early autumn.

3. There was an exponential decrease in serum vitamin B12 concentration with time in captivity for bats fed on a vitamin B12-deficient, all-fruit diet; the biological half-life was 80 d in serum, 109 d in liver and 164 d in kidney.

4. The main storage organ for vitamin B12 in the bat was the liver, mean content 1067 ng vitamin B12. After 50 d, injected [57Co]cyanocobalamin had equilibrated with body vitamin B12 stores, and 17% of the retained radioactivity was present in the liver. From these results it was calculated that the total body vitamin B12 content of the bat was c. 6500 ng.

5. The biological half-life of injected [57Co]cyanocobalamin was 70–88 d and the calculated daily requirement was 50–60 ng (0.2 μg/kg body-weight per d).

6. As serum vitamin B12 levels decreased, serum folate levels increased. The erythrocyte folate concentration increased significantly after 130 d on the all-fruit diet and then decreased to the initial values after 190 d.

7. Vitamin B12 metabolism in the fruit bat is similar in many respects to that of man, but on a ‘weight-for-weight’ basis the bat has a 5- to 15-fold greater requirement for this vitamin.

8. Vitamin B12 deficiency may be induced fairly rapidly in fruit bats fed on an all-fruit diet.

Type
Papers of direct relevance to Clinical and Human Nutrition
Information
British Journal of Nutrition , Volume 34 , Issue 3 , November 1975 , pp. 397 - 410
Copyright
Copyright © The Nutrition Society 1975

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