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A trial of the effects of soya-bean flour and soya-bean saponins on plasma lipids, faecal bile acids and neutral sterols in hypercholesterolaemic men

Published online by Cambridge University Press:  09 March 2007

G. D. Calvert ,
Lesley Blight ,
R. J. Illman ,
D. L. Topping  and
J. D. Potter
G. D. Calvert
Affiliation:
Department of Clinical Biochemistry, Flinders Medical Centre, Bedford Park, South Australia 5042, Australia
Lesley Blight
Affiliation:
Department of Clinical Biochemistry, Flinders Medical Centre, Bedford Park, South Australia 5042, Australia
R. J. Illman
Affiliation:
CSIRO Division of Human Nutrition, Kintore Avenue, Adelaide, South Australia 5000, Australia
D. L. Topping
Affiliation:
CSIRO Division of Human Nutrition, Kintore Avenue, Adelaide, South Australia 5000, Australia
J. D. Potter
Affiliation:
CSIRO Division of Human Nutrition, Kintore Avenue, Adelaide, South Australia 5000, Australia
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Abstract

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1. The hypothesis that soya-bean saponins, by binding bile salts in the gastrointestinal lumen, are responsible for some of the plasma-cholesterol-lowering effect of soya-bean preparations, was tested. In a double-blind crossover study 50 g soya-bean flour/d, containing either 22 or 4 g saponins/kg (adjusted by ethanol extraction) was incorporated in biscuits as a substitute for biscuits or bread into the diet of ten outpatient hypercholesterolaemic men over two consecutive 4-week study periods. The diet was monitored to ensure constancy, saponin-rich foods excluded, faeces collected for bile acid and neutral sterol analysis, and blood taken for plasma lipoprotein lipid analysis.

2. Neither diet had any effect on cholesterol in any plasma lipoprotein fraction, on fasting plasma triglyceride, or on faecal bile acids and neutral sterols.

3. These results suggested that soya-bean saponins are not responsible for the hypocholesterolaemic effect of soya-bean products.

Type
Papers of direct relevance to Clinical and Human Nutrition
Information
British Journal of Nutrition , Volume 45 , Issue 2 , March 1981 , pp. 277 - 281
Copyright
Copyright © The Nutrition Society 1981

References

REFERENCES

Basu, N. & Rastogi, R. P. (1967). Phytochemistry 6, 1249.CrossRefGoogle Scholar
Birk, Y. (1969). In Toxic Constituents of Plant Foodstufs [Liener, I. E. editor]. New York: Academic Press.Google Scholar
Carroll, K. K., Giovannetti, P. M., Huff, M. W., Moase, O., Roberts, D. C. K. & Wolfe, B. M. (1978). Am. J. clin. Nutr. 31, 1312.CrossRefGoogle Scholar
Griminger, P. & Fisher, H. (1958). Proc. Soc. exp. Biol. 99, 424.CrossRefGoogle Scholar
Hodges, R. E., Krehl, W. A., Stone, D. B. & Lopez, A. (1967). Am. J. clin. Nutr. 20, 198.CrossRefGoogle Scholar
Huff, M. W., Hamilton, R. M. G. & Carroll, K. K. (1977). Atherosclerosis 28, 187.CrossRefGoogle Scholar
Kritchevsky, D., Tepper, S. A., Williams, D. E. & Story, J. A. (1977). Atherosclerosis 26, 397.CrossRefGoogle ScholarPubMed
Lipid Research Clinics Program (1974). Manual of Laboratory Operations, Lipidand Lipoprotein Analysis. DHEWPublication No. (NIH) 7–28.Google Scholar
Malinow, M. R. (1979). Vth Inr. Symp. Atherosclerosis, Houston, Texas. (Abstr. no. 302).Google Scholar
Malinow, M. R., McLaughlin, P., Kohler, G. O. & Livingston, A. L. (1977). Steroids 29, 105.CrossRefGoogle Scholar
Malinow, M. R., McLaughlin, P., Papworth, L., Stafford, C., Kohler, G. O., Livingston, A. L. & Cheeke, P. R. (1977). Am. J. clin. Nutr. 30, 2061.CrossRefGoogle Scholar
Munoz, J. M., Sandstead, H. H., Jacob, R. A., Logan, G. M., Reck, S. J., Klevay, L. M. & Shuey, W. C. (1979). Am. J. clin. Nutr. 32, 580.CrossRefGoogle Scholar
Newman, H. A. I., Kummerow, F. A. & Scott, H. M. (1958). Poult. Sci. 37, 42.CrossRefGoogle Scholar
Oakenfull, D. G. & Fenwick, D. E. (1978). Br. J. Nutr. 40, 299.CrossRefGoogle Scholar
Oakenfull, D. G., Fenwick, D. E., Hood, R. L., Topping, D. L., Illman, R. J. & Storer, G. B. (1979). Br. J. Nutr. 42, 209.CrossRefGoogle Scholar
Paul, A. A. & Southgate, D. A. T. (1978). McCance and Widdowson's The Composition of Foodr. London: H.M. Stationery Office.Google Scholar
Potter, J. D., Illman, R. J., Calvert, G. D., Oakenfull, D. G. &Topping, D. L. (1980). Nutr. Rep. int.(In the Press).Google Scholar
Potter, J. D., Topping, D. L. & Oakenfull, D. G. (1979). Lancet i, 223.CrossRefGoogle Scholar
Sautier, C., Doucet, C., Flament, C. & Lemonnier, D. (1979). Atherosclerosis 34, 233.CrossRefGoogle Scholar
Shibata, N. (1961). Med. J. Osaka Univ. 12, 297.Google Scholar
Sirtori, C. R., Agradi, E., Conti, F., Mantero, O. & Gatti, E. (1977). Lancet i, 275.CrossRefGoogle Scholar
Sirtori, C. R., Gatti, E., Mantero, O., Conti, F., Agradi, E., Tremoli, E., Sirtori, M., Fratemgo, L., Tavazzi, L. & Kritchevsky, D. (1979). Am. J. clin. Nutr. 32, 1645.CrossRefGoogle Scholar
Topping, D. L., Illman, R. J., Dreosti, I. E., Trimble, R. P. & Record, I. R. (1978). Nutr. Rep. int. 18, 631.Google Scholar
Topping, D. L., Storer, G. B., Calvert, G. D., Illman, R. J., Oakenfull, D. G. & Weller, R. A. (1980). Am. J. clin. Nutr. 33, 783.CrossRefGoogle Scholar
Topping, D. L., Trimble, R. P., Illman, R. J., Potter, J. D. & Oakenfull, D. G. (1980). Nutr. Rep. int. (In the Press.)Google Scholar
Warnick, G. R. & Albers, J. J. (1978). J. Lipid Res. 19, 65.CrossRefGoogle Scholar