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Study of the effects of dietary fish intake on serum lipids and lipoproteins in two populations with different dietary habits

  • Isabel C. Torres (a1), Lurdes Mira (a2), Cristina P. Ornelas (a3) and Amélia Melim (a3)

Abstract

Increased concentrations of n-3 polyunsaturated fatty acids (PUFA), namely eicosapentaenoic acid (20 : 5; EPA) and docosahexaenoic acid (22 : 6; DHA), have been shown to be beneficial in coronary artery disease (CAD). In the present study, the relationships between fish intake and concentrations of serum EPA and DHA and the effects of these fatty acids on serum lipids and lipoproteins were investigated. Two groups of men, one living in a fishing village and the other in a farming village, participated in this study. The daily fish consumption was ten times greater in the fishing village group than in the rural village group and the mortality from IHD in the rural village was four times higher. Serum concentrations of EPA and DHA were significantly higher in the fishing village group (P < 0·001). In this group, the serum concentration of arachidonic acid (20 : 4; AA), was significantly lower (P < 0·001), and the ratio EPA : AA was twice that of the rural village (P < 0·001). Moreover, in the fishing village group, the serum triacylglycerol and total cholesterol levels were significantly lower than those observed in the rural village (P < 0·01 and P < 0·05 respectively). In the fishing village group the serum LDL-cholesterol concentration was also lower, although the difference was not significant. Our results reinforce the hypothesis that a high intake of n-3 PUFA provides protection against CAD.

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Copyright

Corresponding author

*Corresponding author: Dr Isabel C. Torres, fax +351 91 705149, email isat@dragoeiro.uma.pt

References

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Ascherio, A, Rimm, EB, Stampfer, MJ, Giovannucci, EL and Willett, WC (1995) Dietary intake of marine n-3 fatty acids, fish intake, and the risk of coronary disease among men. New England Journal of Medicine 332, 977982.
Bang, HO and Dyerberg, J (1972) Plasma lipids and lipoproteins in Greenlandic West-coast Eskimos Acta Medica Scandinavica 192, 8594.
Bang, HO, Dyerberg, J and Nielsen, AB (1971) Plasma lipid and lipoprotein pattern in Greenlandic west-coast Eskimos. Lancet i, 11431144.
Bang, HO, Dyerberg, J and Sinclair, HM (1980) The composition of the Eskimo food in north western Greenland. American Journal of Clinical Nutrition 33, 26572661.
Bronsgeest-Schoute, HC, Van Gent, CM, Luten, JB and Ruiter, A (1981) The effect of various intakes of ω-3 fatty acids on blood lipid composition in healthy humans. American Journal of Clinical Nutrition 34, 17521757.
Castelli, WP (1983) Cardiovascular disease and multifactorial risk: challenge of the 1980s. American Heart Journal 106, 11911200.
Christie, WW (1989) The analysis of fatty acids. In Gas Chromatography and Lipids, pp. 6768Glasgow, Ayr, Scotland: The Oily Press.
Daviglus, ML, Stamler, J, Orencia, AJ, Dyer, AR, Liu, K, Greenland, P, Walsh, MK, Morris, D and Shekelle, RB (1997) Fish consumption and the 30-year risk of fatal myocardial infarction. New England Journal of Medicine 336, 10461053.
DeLany, JP, Vivian, VM, Snook, JT and Anderson, PA (1990) Effects of fish oil on serum lipids in men during a controlled feeding trial. American Journal of Clinical Nutrition 52, 477485.
Dyerberg, J, Bang, HO and Hjørne, N (1975) Fatty acid composition of the plasma lipids in Greenland Eskimos. American Journal of Clinical Nutrition 28, 958966.
Dyerberg, J, Bang, HO, Stofferson, E, Moncada, S and Vane, JR (1978) Eicosapentaenoic acid and prevention of thrombosis and atherosclerosis?. Lancet ii, 117119.
Folch, J, Lees, M and Stanley, GHS (1957) A simple method for the isolation and purification of total lipides from animal tissues. Journal of Biological Chemistry 226, 497507.
Friedewald, WT, Levy, RI and Fredrickson, DS (1972) Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clinical Chemistry 18, 499502.
Glantz, AS (1992) Primer of Biostatics. New York, NY: McGraw-Hill.
Glomset, JA (1985) Fish, fatty acids, and human health. New England Journal of Medicine 312, 12531254.
Goncalves Ferreira, FA & Da Silva, ME (1985) Composicão dos Alimentos Portugueses (Composition of Portuguese Foods). Lisbon: Instituto Nacional de Saúde.
Goodnight, SH (1996) The fish oil puzzle. Science and Medicine 3, 4251.
Harris, WS (1989) Fish oils and plasma lipid and lipoprotein metabolism in humans: a critical review. Journal of Lipid Research 30, 785807.
Harris, WS (1994) The benefits and pathologies from excesses and deficiencies of dietary fatty acids. Current Opinion in Endocrinology and Diabetes 1, 260266.
Harris, WS (1997) n-3 fatty acids and serum lipoproteins: human studies. American Journal of Clinical Nutrition 65, 1645S1654S.
Hirai, A, Hamazaki, T, Terano, T, Nishikawa, T, Tamura, Y and Sajiki, J (1980) Eicosapentaenoic acid and platelet function in Japanese (letter). Lancet ii, 11321133.
Hirai, A, Terano, T, Saito, H, Tamura, Y & Yoshida, S (1987) Clinical and epidemiological studies of eicosapentaenoic acid in Japan. In Polyunsaturated Fatty Acids and Eicosanoids, pp. 924 [Lands, WEM, editor]. Champaign IL: American Oil Chemists' Society.
Illingworth, DR, Harris, WS and Connor, WE (1984) Inhibition of low density lipoprotein synthesis by dietary omega-3 fatty acids in humans. Arteriosclerosis 4, 270275.
Jennings, W (1987) Analytical Gas Chromatography. New York, NY: Academic Press.
Kagawa, Y, Nishizawa, M, Suzuki, M, Miyatake, T, Hamamoto, T, Goto, K, Motonaga, E, Izumikawa, H, Hirata, H and Ebihara, A (1982) Eicosapolyenoic acids of serum lipids of Japanese islanders with low incidence of cardiovascular diseases. Journal of Nutritional Science and Vitaminology 28, 441453.
Kannel, WB, Thomas, HE and Kjelsberg, MO (1986) Overall and coronary heart disease mortality rates in relation to major risk factors in 325,348 men screened for the MRFIT. American Heart Journal 112, 825836.
Kromhout, D, Bosschieter, EB and Coulander, CL (1985) The inverse relation between fish consumption and 20-year mortality from coronary heart disease. New England Journal of Medicine 312, 12051209.
Leaf, A & Weber, PC (1988 a) Omega-3 fatty acids and cardiovascular disease. In Heart Disease and Update, pp. 4960 [Braunwald, E, editor]. Philadelphia, PA and London: WB Saunders Company.
Leaf, A and Weber, PC (1988) Cardiovascular effects of n-3 fatty acids. New England Journal of Medicine 318, 549557.
Lovegrove, JA, Brooks, CN, Murphy, MC, Gould, BJ and Williams, CM (1997) Use of manufactured foods enriched with fish oils as a means of increasing long-chain n-3 polyunsaturated fatty acid intake. British Journal of Nutrition 78, 223236.
Nordøy, A (1991) Is there a rational use for n-3 fatty acids (fish oils) in clinical medicine?. Drugs 42, 331342.
Parkinson, AJ, Cruz, AI, Heyward, WL, Bulkow, LR, Hall, D, Barstaed, L and Connor, WE (1994) Elevated concentrations of plasma ω-3 polyunsaturated fatty acids among Alaskan Eskimos. American Journal of Clinical Nutrition 59, 384388.
Reis, GJ, David, IS, Boucher, TM, Sipperly, ME, Horowitz, GL, Sacks, FM and Pasternak, RC (1990) Effects of two types of fish oil supplements on serum lipids and plasma phospholipid fatty acids in coronary artery disease. American Journal of Cardiology 66, 11711175.
Willett, WC, Sampson, L, Stampfer, MJ, Rosner, B, Bain, C, Witschi, J, Hennekens, CH and Speizer, FE (1985) Reproducibility and validity of a semiquantitative food frequency questionnaire. American Journal of Epidemiology 122, 5165.
Willett, WC, Stampfer, MJ, Underwood, BA, Speizer, FE, Rosner, B and Hennekens, CH (1983) Validation of a dietary questionnaire with plasma carotenoid and alpha-tocopherol levels. American Journal of Clinical Nutrition 38, 631639.
World Health Organization (1990) Nutrition and Prevention of Chronic Diseases. Technical Report Series no. 797. Geneva: WHO.

Keywords

Study of the effects of dietary fish intake on serum lipids and lipoproteins in two populations with different dietary habits

  • Isabel C. Torres (a1), Lurdes Mira (a2), Cristina P. Ornelas (a3) and Amélia Melim (a3)

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