Hostname: page-component-8448b6f56d-t5pn6 Total loading time: 0 Render date: 2024-04-24T10:26:46.559Z Has data issue: false hasContentIssue false
  • English
  • Français

Studies on vitamin D metabolism in malnourished children

Published online by Cambridge University Press:  24 July 2007

N. Raghuramulu  and
Vinodini Reddy
N. Raghuramulu
Affiliation:
National Institute of Nutrition, Indian Council of Medical Research, Jamai Osmania (PO), Hyderabad – 500 007, A P, India
Vinodini Reddy
Affiliation:
National Institute of Nutrition, Indian Council of Medical Research, Jamai Osmania (PO), Hyderabad – 500 007, A P, India
Rights & Permissions [Opens in a new window]

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

1. Basal levels of serum 25-hydroxy vitamin D (25-OHD) were estimated in ten normal children and twenty-seven children with protein–energy malnutrition.

2. Five normal children and fourteen malnourished children were administered a single massive dose of 15 mg vitamin D orally and the remaining children received oral supplements of 50 μg vitamin D daily for 20 d. Blood samples were obtained after 10 and 20 d of dosing and serum 25-OHD levels were repeated.

3. The basal serum 25-OHD levels were significantly lower (P < 0·05) in malnourished children than in normal children.

4. Administration of a single massive dose of vitamin D as well as daily supplementation of small doses resulted in significant increases in serum 25-OHD levels within 10 d. However, the increase with a massive dose was of a higher magnitude. There was no significant difference between the normal and malnourished children.

5. The binding capacity of serum to 25-OHD was similar in both the groups.

6. These results suggest that vitamin D metabolism is not altered in protein–energy malnutrition.

Type
Papers of direct reference to Clinical and Human Nutrition
Information
British Journal of Nutrition , Volume 47 , Issue 2 , March 1982 , pp. 231 - 234
Copyright
Copyright © The Nutrition Society 1982

References

Avioli, L. V. & Haddad, J. G. (1973). Metabolism 12, 507.CrossRefGoogle Scholar
Belsey, R. E., Deluca, H. F. & Potts, J. T. Jr. (1974). J. clin. Endocr. Metab. 38, 1046.CrossRefGoogle Scholar
Bodansky, A. (1933). J. biol. Chem. 101, 93.CrossRefGoogle Scholar
Chen, P. S. Jr, Toribara, T. Y. & Warner, H. (1956). Analyt. Chem. 28, 1756.CrossRefGoogle Scholar
Imawari, M., Akanuma, Y., Itakura, H., Muto, Y., Kosaka, K. & Goodman, D. S. (1979). J. Lab. clin. Med. 93, 171.Google Scholar
Lowry, D. A., Rosebrough, N. J., Farr, A. L. & Randall, R. J. (1951). J. biol. Chem. 193, 265.CrossRefGoogle Scholar
Manchanda, S. S. & Lai, H. (1972). Ind. J. Pediat. 39, 52.CrossRefGoogle Scholar
Poskitt, E. M. E., Cole, T. J. & Lawson, D. E. M. (1979). Br. Med. J. 1, 221.CrossRefGoogle Scholar
Pramanik, A. K., Gupta, S. & Agarwal, P. S. (1971). Ind. Pediat. 8, 95.Google Scholar
Raghuramulu, N. & Reddy, V. (1980). Archs Dis. Childh. 55, 285.CrossRefGoogle Scholar
Rao, D. H., Satyanarayana, K. & Gowrinath Sastry, J. (1976). Ind. J. Med. Res. 64, 629.Google Scholar
Stamp, T. C. B. (1975). Proc. Nutr. Soc. 34, 119.CrossRefGoogle Scholar
Stamp, T. C. B., Haddad, J. G. & Twigg, C. A. (1977). Lancet i, 1341.CrossRefGoogle Scholar
Whyte, M. P., Haddad, J. G. Jr, Walters, D. D. & Stamp, T. C. B. (1979). J. clin. Endocr. Metab. 48, 906.CrossRefGoogle Scholar