Hostname: page-component-7479d7b7d-8zxtt Total loading time: 0 Render date: 2024-07-12T06:22:07.342Z Has data issue: false hasContentIssue false
  • English
  • Français

Studies on iron availability in man, using stable isotope techniques

Published online by Cambridge University Press:  09 March 2007

Susan J. Fairweather-Tait  and
Margaret J. Minski
Susan J. Fairweather-Tait
Affiliation:
AFRC Food Research Institute Norwich, Colney Lane, Norwich NR4 7UA
Margaret J. Minski
Affiliation:
Imperial College Reactor Centre, Silwood Park, Ascot, Berkshire SL5 7PY
Rights & Permissions [Opens in a new window]

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

1. Iron absorption from 10 mg Fe (as ferrous sulphate), labelled with 1.3 mg 58Fe, was measured in fasting, non-anaemic adult subjects by the faecal-balance technique. The measurement was performed twice, each subject being given, in random order, either 50 mg Fe or a placebo 18 h before the 58Fe-labelled FeSO4.

2. The 50 mg Fe load significantly reduced Fe absorption the following day (P < 0.01), from a mean of 35.4 (SEM 4.6)% to 29.0 (SEM 5.1)%. This points to the importance of strict dietary control during Fe-absorption studies to eliminate bias in results.

3. In a separate study, the feasibility of using S6Fe-enrichment of erythrocytes, measured by neutron activation analysis (NAA), 10 d after a meal labelled with 0.69 mg 58Fe as an index of Fe absorption was examined. The levels of 58Fe in the blood were detectable by NAA. Regression analysis showed a significant relation between 58Fe-enrichment of blood and 58Fe absorption, calculated as the difference between intake and faecal excretion (R 0.59, P < 0.05).

Type
Papers of direct relevance to Clinical and Human Nutrition
Information
British Journal of Nutrition , Volume 55 , Issue 2 , March 1986 , pp. 279 - 285
Copyright
Copyright © The Nutrition Society 1986

References

REFERENCES

Alvey, N. G., Banfield, C. F., Baxter, R. I., Gower, J. C., Krzanowski, W. J., Lane, P. W., Leech, P. W., Nelder, J. A., Payne, R. W., Phelps, K. M., Rogers, C. E., Ross, G. J. S., Simpson, H. R., Todd, A. D., Tunnicliffe-wilson, G., Wedderburn, R. W. M., White, R. P. & Wilkinson, G. N. (1977). The GENSTAT Manual. Oxford: Rothamstead Experimental Station, Numerical Algorithms Group Ltd.Google Scholar
Bothwell, T. H., Charlton, R. W., Cook, J. D. & Finch, C. A. (1979). Iron Metabolism in Man, p. 431. Oxford: Blackwell.Google Scholar
Cook, J. D., Layrise, M. & Finch, C.A. (1969). Blood 33, 421–429.CrossRefGoogle Scholar
Eagles, J., Fairweather-Tait, S. J. & Self, R. (1985). Analytical Chemistry 57, 469–471.CrossRefGoogle Scholar
Fairweather-Tait, S. J., Minski, M. J. & Richardson, D. P. (1983). British Journal of Nutrition 50, 51–60.CrossRefGoogle Scholar
Fairweather-Tait., S. J., Swindell, T. E. & Wright, A. J. A. (1985). British Journal of Nutrition 54, 79–86.CrossRefGoogle Scholar
Fairweather-Tait, S. J. & Wright, A. J. A. (1984). British Journal of Nutrition 51, 185–191.CrossRefGoogle Scholar
Hahn, P. F., Bale, W. F., Laurence, E. O. & Whipple, G. H. (1939). Journal of Experimental Medicine 69, 739–753.CrossRefGoogle Scholar
Heinrich, H. C. & Fischer, R. (1982). Klinische Wochenschrift 60, 1493–1496.CrossRefGoogle Scholar
Janghorbani, M. & Young, V. R. (1980). American Journal of Clinical Nutrition 33, 2021–2030.CrossRefGoogle Scholar
Martinez-Torres, C., Romano, E. L., Renzi, M. & Layrisse, M. (1979). American Journal of Clinical Nutrition 32, 809–816.CrossRefGoogle Scholar
Ross, J. F. & Chapin, M. A. (1941). Journal of Clinical Investigation 20, 437.Google Scholar
Rossander, L., Hallberg, L. & Bjorn-Rasmussen, E. (1979). American Journal of Clinical Nutrition 32, 2484–2489.CrossRefGoogle Scholar
Siegel, S. (1956). Nonparametric Statistics for the Behavioural Sciences, pp. 75–83. Tokyo: McGraw-Hill Kogakusha Ltd.Google Scholar
Snedecor, G.W., & Cochran, W. G. (1973). Statistical Methods, 6th ed., pp. 91–99. Ames, Iowa: Iowa State University Press.Google Scholar
Solomons, N. W., Pineda, O., Viteri, F. & Sandstead, H. H. (1983). Journal of Nutrition 113, 337–349.CrossRefGoogle Scholar
Trinidad, T. P., Aguilar, C. G., Halili, D. V., Alba, A. M. & Roxas, B. V. (1980). Philippine Journal of Nutrition 33, 183–189.Google Scholar
Wennesland, R., Brown, E., Hopper, J. Jr, Hodges, J. L. Jr., Guttentag, O. E., Scott, K. G., Tucker, I. N. & Bradley, B. (1959). Journal of Clinical Investigation 38, 1065–1077.CrossRefGoogle Scholar