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Streptozotocin-induced diabetes lowers retinol-binding protein and transthyretin concentrations in rats

Published online by Cambridge University Press:  09 March 2007

P. J. Tuitoek ,
S. J. Rittere ,
J. E. Smitha  and
T. K. Basu
P. J. Tuitoek
Affiliation:
Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, Alberta, CanadaT6G 2P5
S. J. Rittere
Affiliation:
Nutrition Department, The Pennsylvania State University, University Park, PA16802-6504. USA
J. E. Smitha
Affiliation:
Nutrition Department, The Pennsylvania State University, University Park, PA16802-6504. USA
T. K. Basu
Affiliation:
Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, Alberta, CanadaT6G 2P5
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Abstract

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Retinol-binding protein (RBP) and transthyretin (TTR) in the plasma, liver and kidney, retinol in plasma, and total vitamin A in the liver were measured in rats 6 weeks after diabetes mellitus had been induced by streptozotocin (STZ). The diabetic rats gained 83% less weight despite consuming 45% more feed than the non-diabetic controls. Plasma and kidney concentrations of RBP and TTR were significantly lower in diabetic than in the non-diabetic control rats. Unlike the retinol carrier proteins, plasma albumin concentrations remained unaffected. Plasma concentrations of retino1 were decreased while its hepatic levels increased in the diabeticanimals. The depressed circulatory levels of retinol may reflect an altered metabolism of its transport proteins

Keywords

StreptozotocinDiabetes mellitnsRetinol-binding proteinTransthyretinVitamin A
Type
General Nutrition
Information
British Journal of Nutrition , Volume 76 , Issue 6 , December 1996 , pp. 891 - 897
Copyright
Copyright © The Nutrition Society 1997

References

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