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Soluble-fibre concentrate lowers plasminogen activator inhibitor-1 in baboons (Papio ursinus)

Published online by Cambridge University Press:  09 March 2007

C. S. Venter
Nutrition Research Group, Potchefstroom University, Potchefstroom, South Africa
C. J. Nel
Nutrition Research Group, Potchefstroom University, Potchefstroom, South Africa
H. H. Vorster
Nutrition Research Group, Potchefstroom University, Potchefstroom, South Africa
J. C. Jerling
Nutrition Research Group, Potchefstroom University, Potchefstroom, South Africa
W. Oosthuizen
Nutrition Research Group, Potchefstroom University, Potchefstroom, South Africa
F. J. Veldman
Nutrition Research Group, Potchefstroom University, Potchefstroom, South Africa
J. A. Kellerman
Nutrition Research Group, Potchefstroom University, Potchefstroom, South Africa
C. M. Smuts
National Research Programme for Nutritional Intervention, Tygerberg, South Africa
W. J. H. Vermaak
Department of Chemical Pathology, University of Pretoria, South Africa
D. G. Van Der Nest
Nutrition Research Group, Potchefstroom University, Potchefstroom, South Africa
J. H. Ridder
Department of Biokinetics, Potchefstroom University, Potchefstroom, South Africa
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The effects of a soluble NSP (fibre) concentrate (SFC) on plasma fibrinogen and plasminogen activator inhibitor-1 (PAI-1), serum and liver lipids and lipoproteins and glucose tolerance were compared with those of bezafibrate (BF), a lipid-lowering drug, in obese baboons (Papio ursinus) The basal diet was a high-fat (37% of total energy), low-NSP (12.4 g/d) Westernized diet, supplemented for 8 weeks with either 20 SFCg/baboon per d or 6.7 mg BF/kg body weight per baboon per d. SFC supplementation significantly lowered PAI-1, total serum cholesterol, HDL-cholesterol and circulating free fatty acid levels. BF significantly lowered total serum cholesterol, but unexpectedly raised serum triacylglycerol levels. Although not statistically significant, the mean liver tricacylglycerol concentration of baboons fed on BF was lower than that of baboons fed on SFC supplements. These results suggest that: (1) the mechanism of action of the two cholesterol-lowering treatments differ, with BF having a liver triacylglycerol-lowering effect and (2) the SFC had additional beneficial effect on fibrinolysis by lowering PAI-1 levels.

General Nutrition
Copyright © The Nutrition Society 1997



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