Hostname: page-component-76fb5796d-vfjqv Total loading time: 0 Render date: 2024-04-26T14:08:41.524Z Has data issue: false hasContentIssue false
  • English
  • Français

Similar serum lipoprotein reductions by lipid-lowering diets with different polyunsaturated:saturated fat values

Published online by Cambridge University Press:  24 July 2007

Inga-Britt Gustafsson ,
J. Boberg ,
B. Karlström ,
H. Lithell  and
B. Vessby
Inga-Britt Gustafsson
Affiliation:
Department of Geriatrics, University of Uppsala, Uppsala, Sweden
J. Boberg
Affiliation:
Department of Geriatrics, University of Uppsala, Uppsala, Sweden
B. Karlström
Affiliation:
Department of Geriatrics, University of Uppsala, Uppsala, Sweden
H. Lithell
Affiliation:
Department of Geriatrics, University of Uppsala, Uppsala, Sweden
B. Vessby
Affiliation:
Department of Geriatrics, University of Uppsala, Uppsala, Sweden
Rights & Permissions [Opens in a new window]

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

1. Lipid-lowering diets enriched in polyunsaturated fat decrease the serum cholesterol in hyperlipoproteinaemia, usually by reducing both the low-density-lipoprotein (LDL) and high-density-lipoprotein (HDL) cholesterol concentrations. The aim of the present study was to investigate whether the effects on LDL could be maintained but those on HDL cholesterol be diminished by reducing the ratio, polyunsaturated: saturated fat (P:S) of the diet.

2. Twenty hyperlipoproteinaemic patients (six with type IIa, eight with type IIb and six with type IV) in a metabolic ward were given two fat-modified diets during two consecutive 3–week periods in a randomized order. The diets were identical with regard to nutrient composition but differed with regard to the P:S values, which were 2.0 and 1.3 respectively.

3. The lipoprotein-lipid composition and serum apolipoprotein concentrations were similar at the end of the two dietary periods in type IIa and type IV patients but in type IIb patients a more pronounced reduction of the LDL-cholesterol concentration by 9% (P < 0·05) was achieved on the diet with the higher P:S value. The HDL-cholesterol did not differ significantly.

4. The results indicate that increasing the P:S value of lipid-lowering diets from 1.3 to 2·0 does not offer a great advantage with regard to the lipoprotein-lipid reductions achieved in moderate hyperlipoproteinaemia.

Type
Research Article
Information
British Journal of Nutrition , Volume 50 , Issue 3 , November 1983 , pp. 531 - 537
Copyright
Copyright © The Nutrition Society 1983

References

Beaumont, J. L., Carlson, L. A., Cooper, G. R., Fejfar, Z., Fredrickson, D. S. & Strasser, T. (1970). Bulletin of the World Health Organization 42, 891–915.Google Scholar
Boberg, J., Gustafsson, I.-B., Karlström, B., Lithell, H., Vessby, B. & Werner, I. (1978). Rheinisch-Westfälische Akademie der Wissenschaften 63, 81–87.Google Scholar
Boberg, J., Gustafsson, I.-B., Karlström, B., Lithell, H., Vessby, B. & Werner, I. (1981). Annals of Nutrition and Metabolism 25, 320–331.CrossRefGoogle Scholar
Burstein, M. & Samaille, J. (1960). Clinica Chimica Acta 5, 609.CrossRefGoogle Scholar
Chait, A., Onitiri, A., Nicoll, A., Rabaya, E., Davies, J. & Lewis, B. (1974). Atherosclerosis 20, 347–364.CrossRefGoogle Scholar
Deckelbaum, R. J., Shipley, G. G., Tall, A. R. & Small, D. M. (1977). In Protides of the Biological Fluids, vol. 25, pp. 91–98 [Peeters, H., editor]. New York: Pergamon Press.Google Scholar
Ernst, N., Fisher, M., Bowen, P., Schaefer, E. J. & Levy, R. I. (1980). Lancet ii, 111–113.CrossRefGoogle Scholar
Gordon, T., Castelli, W. P., Hjortland, M. C., Kannel, W. B. & Dawber, T. R. (1977). American Journal of Medicine 62, 707–714.CrossRefGoogle Scholar
Havel, R. J., Eder, H. H. & Bragdon, J. H. (1955). Journal of Clinical Investigation 34, 1345–1353.CrossRefGoogle Scholar
Jackson, R. L., Taunton, O. D., Morrisett, J. D. & Gotto, A. M. Jr (1978). Circulation Research 42, 447–453.CrossRefGoogle Scholar
Langer, T., Levy, R. I. & Fredrickson, D. S. (1969). Circulation 40 (Suppl. III), 14 (Abstr.).Google Scholar
Lewis, B., Katan, M., Merkx, I., Miller, N. E., Hammet, F., Kay, R. M., Nobels, A. & Swan, A. V. (1981). Lancet vii, 1310–1313.CrossRefGoogle Scholar
Morrisett, J. D., Pownall, H. J., Jackson, R. L., Segura, R., Gotto, A. M. & Taunton, O. D. (1977). In Polyunsaturated Fatty Acids, pp. 139–161 [Holman, R. T.Kunau, W. H. and Champaign, I. U., editors]. Washington DC: American Oil Chemists' Society.Google Scholar
Rush, R. J., Leon, L. & Turrell, J. (1971). Advances in Automatic Analyses 1, 503–507.Google Scholar
Schaefer, E. J., Levy, R. I., Ernst, N. D., van Saut, F. D. & Brewer, H. B. (1981). American Journal of Clinical Nutrition 34, 1758–1763.CrossRefGoogle Scholar
Shepherd, J., Packard, C. J., Grundy, S. M., Yeshurun, D., Gotto, A. M. Jr & Taunton, O. D. (1980). Journal of Lipid Research 21, 91–99.CrossRefGoogle Scholar
Shepherd, J., Packard, C. J., Patsch, J. R., Gotto, A. M. Jr & Taunton, O. D. (1978). Journal of Clinical Investigation 61, 1582–1592.CrossRefGoogle Scholar
Vessby, B., Boberg, J., Gustafsson, I.-B., Karlström, B., Lithell, H. & Östlund-Lindqvist, A.-M. (1980 a). Atherosclerosis 35, 21–27.CrossRefGoogle Scholar
Vessby, B., Gustafsson, I.-B., Boberg, J., Karlström, B., Lithell, H. & Werner, I. (1980 b). European Journal of Clinical Investigation 10, 193–202.CrossRefGoogle Scholar