1 Stoclet, J-C, Chataigneau, T, Ndiaye, M, et al. (2004) Vascular protection by dietary polyphenols. Eur J Pharmacol 500, 299–313.
2 Cordova, AC, Jackson, LSM, Berke-Schlessel, DW, et al. (2005) The cardiovascular protective effect of red wine. J Am Coll Surg 200, 428–439.
3 Opie, LH & Lecour, S (2007) The red wine hypothesis: from concepts to protective signalling molecules. Eur Heart J 28, 1683–1693.
4 Sato, M, Maulik, N & Das, DK (2002) Cardioprotection with alcohol: role of both alcohol and polyphenolic antioxidants. Ann N Y Acad Sci 957, 122–135.
5 Dudzinski, DM, Igarashi, J, Greif, D, et al. (2006) The regulation and pharmacology of endothelial nitric oxide synthase. Ann Rev Pharmacol Toxicol 46, 235–276.
6 Hattori, R, Otani, H, Maulik, N, et al. (2002) Pharmacological preconditioning with resveratrol: role of nitric oxide. Am J Physiol 282, H1988–H1995.
7 Zou, JG, Wang, ZR, Huang, YZ, et al. (2003) Effect of red wine and wine polyphenol resveratrol on endothelial function in hypercholesterolemic rabbits. Int J Mol Med 11, 317–320.
8 Miatello, R, Vázquez, M, Renna, N, et al. (2005) Chronic administration of resveratrol prevents biochemical cardiovascular changes in fructose-fed rats. Am J Hypertens 18, 864–870.
9 Zhang, H, Morgan, B, Potter, B, et al. (2010) Resveratrol improves left ventricular diastolic relaxation in type 2 diabetes by inhibiting oxidative/nitrative stress: in vivo demonstration with magnetic resonance imaging. Am J Physiol 299, H985–H994.
10 Xia, N, Daiber, A, Habermeier, A, et al. (2010) Resveratrol reverses endothelial nitric-oxide synthase uncoupling in apoprotein E knockout mice. J Pharmacol Exp Ther 335, 149–154.
11 Wallerath, T, Deckert, G, Ternes, T, et al. (2002) Resveratrol, a polyphenolic phytoalexin present in red wine, enhances expression and activity of endothelial nitric oxide synthase. Circulation 106, 1652–1658.
12 Goldberg, DM, Yan, J & Soleas, GJ (2003) Absorption of three wine-related polyphenols in three different matrices by healthy subjects. Clin Biochem 36, 79–87.
13 Walle, T, Hsieh, F, DeLegge, MH, et al. (2004) High absorption but very low bioavailability of oral resveratrol in humans. Drug Metab Dispos 32, 1377–1382.
14 Takahashi, S, Uchiyama, T & Toda, K (2009) Differential effect of resveratrol on nitric oxide production in endothelial F-2 cells. Biol Pharm Bull 32, 1840–1843.
15 Scifo, C, Cardile, V, Russo, A, et al. (2004) Resveratrol and propolis as necrosis and apoptosis inducers in human prostate carcinoma cells. Oncol Res 14, 415–426.
16 Nicholson, SK, Tucker, GA & Brameld, JM (2010) Physiological concentrations of dietary polyphenols regulate vascular endothelial cell expression of genes important in cardiovascular health. Br J Nutr 103, 1398–1403.
17 Takahashi, S & Mendelsohn, ME (2003) Synergistic activation of endothelial nitric-oxide synthase (eNOS) by HSP90 and Akt. J Biol Chem 278, 30821–30827.
18 Jones, R, Baker, MB, Weber, M, et al. (2009) Molecular beacons can assess changes in expression and 3′-polyadenylation of human eNOS mRNA. Am J Physiol 296, C498–C504.
19 Fulton, D, Gratton, JP, MaCabe, TJ, et al. (1999) Regulation of endothelium-derived nitric oxide production by the protein kinase Akt. Nature 399, 597–601.
20 Dimmeler, S, Fleming, I, Fisslthaler, B, et al. (1999) Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation. Nature 399, 601–605.
21 Gehm, BD, McAndrews, JM, Chien, PY, et al. (1997) Resveratrol, a polyphenolic compound found in grapes and wine, is an agonist for the estrogen receptor. Proc Natl Acad Sci U S A 94, 14138–14143.
22 Bowers, JL, Tyulmenkov, VV, Jernigan, SC, et al. (2000) Resveratrol acts as a mixed agonist/antagonist for estrogen receptors α and β. Endocrinology 141, 3657–3667.
23 Inoue, H, Jiang, XF, Katayama, T, et al. (2003) Brain protection by resveratrol and fenofibrate against stroke requires peroxisome proliferator-activated receptor α in mice. Neurosci Lett 352, 203–206.
24 Wood, JG, Rogina, B, Lavu, S, et al. (2004) Sirtuin activators mimic caloric restriction and delay ageing in metazoans. Nature 430, 686–689.
25 Jang, M, Cai, L, Udeani, GO, et al. (1997) Cancer chemopreventive activity of resveratrol, a natural product derived from grapes. Science 275, 218–220.
26 Harikumar, KB & Aggarwal, BB (2008) Resveratrol: a multitargeted agent for age-associated chronic diseases. Cell Cycle 7, 1020–1035.
27 MacRitchie, AN, Jun, SS, Chen, Z, et al. (1997) Estrogen upregulates endothelial nitric oxide synthase gene expression in fetal pulmonary artery endothelium. Circ Res 81, 355–362.
28 Klinge, CM, Blankenship, KA, Risinger, KE, et al. (2005) Resveratrol and estradiol rapidly activate MAPK signaling through estrogen receptors α and β in endothelial cells. J Biol Chem 280, 7460–7468.
29 Goya, K, Sumitani, S, Xu, X, et al. (2004) Peroxisome proliferator-activated receptor α agonists increase nitric oxide synthase expression in vascular endothelial cells. Arterioscler Thromb Vasc Biol 24, 658–663.
30 Xu, J, Xie, Z, Reece, R, et al. (2006) Uncoupling of endothelial nitric oxide synthase by hypochlorous acid: role of NAD(P)H oxidase-derived superoxide and peroxynitrite. Arterioscler Thromb Vasc Biol 26, 2688–2695.