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Relationship between biochemical and clinical indices of B-vitamin deficiency. A study in rural school boys

Published online by Cambridge University Press:  09 December 2008

M. S. Bamji ,
K. V. Rameshwar Sarma  and
G. Radhaiah
M. S. Bamji
Affiliation:
National Institute of Nutrition, Indian Council of Medical Research, Jamai Osmania (P.O.), Hyderabad – 500 007, India
K. V. Rameshwar Sarma
Affiliation:
National Institute of Nutrition, Indian Council of Medical Research, Jamai Osmania (P.O.), Hyderabad – 500 007, India
G. Radhaiah
Affiliation:
National Institute of Nutrition, Indian Council of Medical Research, Jamai Osmania (P.O.), Hyderabad – 500 007, India
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Abstract

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1. A study amongst schoolboys in villages around Hyderabad, India, showed that almost all the boys had riboflavin deficiency, 61% had pyridoxine deficiency, and 9.4% had thiamin deficiency as judged by enzymic tests.

2. The prevalence of angular stomatitis was 41.3% and that of glossitis was 18.2%. Biochemical deficiency of riboflavin and pyridoxine was marginally higher in children with angular stomatitis with or without associated glossitis, than in children without oral lesions.

3. Treatment with B-complex vitamins (containing 4 mg riboflavin and 10 mg pyridoxine) daily for 1 month produced significant reduction in the prevalence of glossitis but had no effect on angular stomatitis. The latter responded to topical application of gentian violet.

4. Small but significant changes in erythrocyte enzymes occurred over the period of 1 month even without vitamin supplements.

5. Results suggest that while glossitis is a relatively early manifestation of riboflavin or pyridoxine deficiency or both, angular stomatitis has a more complex aetiology perhaps associated with infection.

Type
Papers of direct relevance to Clinical and Human Nutrition
Information
British Journal of Nutrition , Volume 41 , Issue 3 , May 1979 , pp. 431 - 441
Copyright
Copyright © The Nutrition Society 1979

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