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Regulatory potential of n-3 fatty acids in immunological and inflammatory processes

Published online by Cambridge University Press:  09 March 2007

H. Grimm ,
K. Mayer ,
P. Mayser  and
E. Eigenbrodt
H. Grimm*
Affiliation:
Department of General and Thoracic Surgery, University of Giessen, Rudolf-Buchheim-Strasse 7, D-35385 Giessen, Germany
K. Mayer
Affiliation:
Department of Internal Medicine II, University of Giessen, Klinikstrasse 36, D-35385 Giessen, Germany
P. Mayser
Affiliation:
Department of Dermatology and Andrology, University of Giessen, Gaffkystrasse 14, D-35385 Giessen, Germany
E. Eigenbrodt
Affiliation:
Institute for Biochemistry and Endocrinology, Veterinary Faculty, University of Giessen, Frankfurter Strasse 100, D- 35392 Giessen, Germany
*
*Corresponding author: Dr Helmut Grimm, MD, fax +49 641 99 44709, email helmut.grimm@chiru.med.uni-giessen.de
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Abstract

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Type
Research Article
Information
British Journal of Nutrition , Volume 87 , Issue S1 , January 2002 , pp. S59 - S67
Copyright
Copyright © The Nutrition Society 2002

References

Aslan, A & Triadafilopoulos, G (1992) Fish oil fatty acid supplementation in active ulcerative colitis: a double-blind, place bo-controlled, crossover study. American Journal of Gastroenterology 87, 432–437.Google Scholar
Baillie, RA, Takada, R, Nakamura, M & Clarke, SD (1999) Coordinate induction of peroxisomal acyl-CoA oxidase and UCP-3 by dietary fish oil: a mechanism for decreased body fat deposition. Prostaglandins, Leukotrienes and Essential Fatty Acids 60, 351–356.CrossRefGoogle ScholarPubMed
Bang, HO, Dyerberg, J & Nielsen, AB (1971) Plasma lipid and lipoprotein pattern in Greenlandic West-coast Eskimos. Lancet 1, 1143–1145.CrossRefGoogle ScholarPubMed
Belluzzi, A, Brignola, C, Campieri, M, Pera, A, Boschi, S & Miglioli, M (1996) Effect of an enteric-coated fish-oil preparation on relapses in Crohn’s disease. New England Journal of Medicine 334, 1557–1560.CrossRefGoogle ScholarPubMed
Berger, A, German, JB, Chiang, BL, Ansari, AA, Keen, CL & Fletcher, MP (1993) Influence of feeding unsaturated fats on growth and immune status of mice. Journal of Nutrition 123, 225–233.Google ScholarPubMed
Bourre, JM, Bonneil, M, Dumont, O, Piciotti, M, Calaf, R, Portugal, H, Nalbone, G & Lafont, H (1990) Effect of increasing amounts of dietary fish oil on brain and liver fatty acid composition. Biochimica et Biophysica Acta 1043, 149–152.CrossRefGoogle Scholar
Braissant, O, Foufelle, F, Scotto, C, Wahli, W (1996) Differential expression of peroxisome proliferator-activated receptors (PPAR): tissue distribution of PPARα, δ, and γ, in the adult rat. Endocrinology 137, 354–366.CrossRefGoogle Scholar
Brown, AJ, Pang, E & Roberts, DCK (1991) Persistent changes in the fatty acid composition of erythrocyte membranes after moderate intake of n-3 polyunsaturated fatty acids: study design implications. American Journal of Clinical Nutrition 54, 668–673.CrossRefGoogle ScholarPubMed
Brown, MS & Goldstein, JL (1999) A proteolytic pathway that controls the cholesterol content of membranes, cells, and blood. Proceedings of the National Academy of Sciences, USA 96, 11041–11048.CrossRefGoogle ScholarPubMed
Calder, PC, Bevan, SJ & Newsholme, EA (1992) The inhibition of T-lymphocyte proliferation is via an eicosanoid-independent mechanism. Immunology 75, 108–115.Google ScholarPubMed
Camandola, S, Leonarduzzi, G, Musso, T, Varesio, L, Carini, R & Scavazza, A (1996) Nuclear factor κB is activated by arachidonic acid but not by eicosapentaenoic acid. Biochemical and Biophysical Research Communications 229, 643–647.CrossRefGoogle Scholar
Campbell, JM, Fahey, GC, Lichtensteiger, CA, DeMichele, SJ & Garleb, KA (1997) An enteral formula containing fish oil, indigestible oligosaccharides, gum arabic and antioxidants affects plasma and colonic phospholipid fatty acid and prostaglandin profiles in pigs. Journal of Nutrition 127, 137–145.CrossRefGoogle ScholarPubMed
Caughey, GE, Mantzioris, E, Gibson, RA, Cleland, LG & James, MJ (1996) The effect on human tumor necrosis factor α, and interleukin 1 β, production of diets enriched in n-3 fatty acids from vegetable oil or fish oil. American Journal of Clinical Nutrition 63, 116–122.CrossRefGoogle ScholarPubMed
Chauncee, JB, Simon, RH & Peters-Golden, M (1988) Rat alveolar macrophages synthesize leukotriene B4 and 12-hydroxyeicosatetraenoic acid from alveolar epithelial cell-derived arachidonic acid. American Review of Respiratory Diseases 139, 928–938.CrossRefGoogle Scholar
Chilton, FH, Patel, M, Fonteh, AN, Hubbard, WC & Triggiani, M (1993) Dietary n-3 fatty acid effects on neutrophil lipid composition and mediator production Influence of duration and dosage. Journal of Clinical Investigation 91, 115–122.CrossRefGoogle ScholarPubMed
Clarke, SD, Armstrong, MK & Jump, DB (1990) Dietary polyunsaturated fats uniquely suppress rat liver fatty acid synthase and S 14 mRNA content. Journal of Nutrition 120, 225–232.CrossRefGoogle Scholar
Clarke, SD, Thullier, P, Baillie, RA & Sha, X (1999) Peroxisome proliferator-activated receptors: a family of lipid-activated transcription factors. American Journal of Clinical Nutrition 70, 566–571.CrossRefGoogle ScholarPubMed
Connor, WE, Neuringer, M & Reisbick, S (1991) Essentiality of ω-3 fatty acids: Evidence from the primate model and implications for human nutrition. In Health Effects of ω-3 Polyunsaturated Fatty Acids in Seafoods pp. 118–132 [Simopoulos, AP, Kifer, RR, Martin, RE and Barlow, SM, editors]. Basel: Karger.Google Scholar
Conolly, KG & Repino, JF (1997) Markers for predicting the development of acute respiratory distress syndrome. Annual Review of Medicine 48, 429–445.CrossRefGoogle Scholar
Collie-Duguid, ESR & Wahle, KWJ (1996) Inhibitory effect of fish oil n-3 polyunsaturated fatty acids on the expression of endothelial cell adhesion molecules. Biochemical and Biophysical Research Communications 220, 969–974.CrossRefGoogle ScholarPubMed
Croset, M, Bayon, Y & Lagarde, M (1992) Incorporation and turnover of eicosapentaenoic and docosahexaenoic acids in human blood platelets in vitro. Biochemical Journal 281, 309–316.CrossRefGoogle ScholarPubMed
Da Silva, AL , De Marcucci, OL & Kuhnle, ZR (1993) Dietary polyunsaturated fats suppress the high-sucrose induced increase of rat liver pyruvate dehydrogenase levels. Biochimica Biophysica Acta 1169, 126–134.CrossRefGoogle ScholarPubMed
Deavergne, B & Wahli, W (1999) Peroxisome proliferator-activated receptors: nuclear control of metabolism. Endocrine Reviews 20, 649–688.Google Scholar
DeCaterina, R & Libby, P (1996) Control of endothelial leukocyte adhesion molecules by fatty acids. Lipids 31, 557–563.Google Scholar
Devchand, PR, Keller, H, Peters, JM, Vazquez, M, Gonzales, FJ & Wahli, W (1996) The PPARα-leukotriene B4 pathway to inflammation control. Nature 384, 39–43.CrossRefGoogle ScholarPubMed
Endres, S, Ghorbani, R, Kelley, VE, Georgilis, K, Lonnemann, G, van der Meer, JWM , Cannon, JG, Rogers, TS, Klempner, MS, Weber, PC, Schaefer, EJ, Wolff, SM & Dinarello, CA (1989) The effect of dietary supplementation with n-3 polyunsaturated fatty acids on the synthesis of interleukin-1 and tumor necrosis factor by mononuclear cells. New England Journal of Medicine 320, 265–271.CrossRefGoogle ScholarPubMed
Fisher, S & Weber, PC (1983) Thromboxane A3 (TxA3) is formed in human platelets after dietary eicosapentaenoic acid (C20:5, n-3). Biochemical and Biophysical Research Communications 116, 1091–1099.CrossRefGoogle Scholar
Foegh, ML (1988) Eicosanoids and platelet activating factor mechanisms in organ rejection. Transplantation Proceedings 20, 1260–1263.Google ScholarPubMed
Forman, BM, Chen, J & Evans, RM (1997) Hypolipidemic drugs, polyunsaturated fatty acids and eicosanoids are ligands for peroxisome proliferator-activated receptors α, and δ. Proceedings of the National Academy of Science, USA 94, 4312–4317.CrossRefGoogle ScholarPubMed
Goetzl, EJ & Pickett, WC (1980) The human PMN leukocyte chemotactic activity of complex hydroxyeicosatetraenoic acids (HETEs). Journal of Immunology 125, 1789–1791.CrossRefGoogle Scholar
Grimm, H, Tibell, A, Norrlind, B, Blecher, C, Wilker, S & Schwemmle, K (1994a) Immunoregulation by parenteral lipids: impact of the n-3 to n-6 fatty acid ratio. Journal of Parenteral and Enteral Nutrition 18, 417–421.CrossRefGoogle ScholarPubMed
Grimm, H, Tibell, A, Norrlind, B, Larsson-Backström, C, Wretlind, A & Groth, CG (1994b) Lipid mediated modification of rat heart allograft survival. Transplant International 7, 247–252.CrossRefGoogle ScholarPubMed
Grimm, H, Tibell, A, Norrlind, B, Schott, J & Bohle, RM (1995) Nutrition and allorejection impact of lipids. Transplant Immunology 3, 62–67.CrossRefGoogle ScholarPubMed
Grimminger, F, Dürr, U & Seeger, W (1992) Ligand-operated synthesis of 4-series and 5-series leukotrienes in human neutrophils: critical dependance on exogenous free fatty acid supply. Molecular Pharmacology 41, 757–766.Google Scholar
Grimminger, F, Grimm, H, Führer, D , Papavassilis, C, Lindemann, G, Blecher, C, Mayer, K, Tabesch, F, Krämer, HJ, Stevens, J & Seeger, W (1996) ω-3 Lipid infusion in a heart allotransplant model Shift in fatty acid and lipid mediator profiles and prolongation of transplant survival. Circulation 93, 365–371.CrossRefGoogle Scholar
Grimminger, F, Wahn, H, Mayer, K, Kiss, L, Walmrath, D & Seeger, W (1997) Impact of arachidonic versus eicosapentaenoic acid on exotoxin-induced lung vascular leakage: relation to 4-series versus 5-series leukotriene generation. American Journal of Respiratory and Critical Care Medicine 155, 513–519.CrossRefGoogle Scholar
Häyry, P (1984) Intragraft events in allograft destruction. Transplantation 38, 1–6.CrossRefGoogle ScholarPubMed
Harris, WS (1997) n-3 fatty acids and serum lipoproteins. Human studies. American Journal of Clinical Nutrition 60:1645S.CrossRefGoogle Scholar
Hawthorne, AB, Daneshmend, TK, Hawkey, CJ, Belluzzi, A, Everitt, SJ, Holmes, GK, Malkinson, C, Shaheen, MZ & Willars, JE (1992) Treatment of ulcerative colitis with fish oil supplementation: a prospective 12 month randomised controlled trial. Gut 33, 922–928.CrossRefGoogle ScholarPubMed
Hughes, DA, Pinder, AC, Piper, Z, Johnson, IT & Lund, EK (1996) Fish oil supplementation inhibits the expression of major histocompatibility complex class II molecules and adhesion molecules on human monocytes. American Journal of Clinical Nutrition 63, 267–272.CrossRefGoogle ScholarPubMed
Inui, K, Fukuta, Y, Ikuda, A, Kameda, H, Kokuba, Y & Sato, M (1996a) The effect of α-linolenic acid-rich emulsion on fatty acid metabolism and leukotriene generation of the colon in a rat model with inflammatory bowel disease. Annals of Nutrition and Metabolism 40, 175–182.CrossRefGoogle Scholar
Inui, K, Fukuta, Y, Ikada, A, Kameda, H, Kokuba, Y & Sato, M (1996b) The nutritional effect of α-linolenic acid-rich emulsion with total parenteral nutrition in a rat model with inflammatory bowel disease. Annals of Nutrition and Metabolism 40, 227–233.CrossRefGoogle Scholar
Issemann, I & Green, S (1990) Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators. Nature 347, 645–650.CrossRefGoogle ScholarPubMed
Jump, D, Clarke, SD, Thelen, A & Liimatta, M (1994) Coordinate regulation of glycolytic and lipogenic gene expression by polyunsaturated fatty acids. Journal of Lipid Research 35, 1076–1084.CrossRefGoogle ScholarPubMed
Jump, DB & Clarke, SD (1999) Regulation of gene expression by dietary fat. Annual Review of Nutrition 19, 83–90.CrossRefGoogle ScholarPubMed
Katsurada, A, Iritani, N, Fukuda, H, Noguchi, T & Tanaka, T (1990) Influence of nutrients and hormones on transcriptional and posttranscriptional regulation of acetyl-CoA Carboxylase in rat liver. European Journal of Biochemistry 190, 435–441.CrossRefGoogle Scholar
Kelley, DS, Nelson, GJ, Serrato, CM, Schmidt, PC & Branch, LB (1988) Effects of type of dietary fat on indices of immune status of rabbits. Journal of Nutrition 118, 1376–1384.CrossRefGoogle ScholarPubMed
Kletzien, RF, Foellmi, LA, Harris, PKW, Wyse, BM & Clarke, SD (1992) Adipocyte fatty acid binding protein (aFABP): regulation of gene expression in vivo and in vitro by an insulin-sensitizing agent. Molecular Pharmacology 42, 558–562.Google ScholarPubMed
Kliewer, SA, Sundseth, SS, Jones, SA, Browns, PJ, Wisely, B & Koble, CS (1997) Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors α, and γ. Proceedings of the National Academy of Science, USA 94, 4318–4323.CrossRefGoogle ScholarPubMed
Kremr, JM (1996) Effects of modulation of inflammatory and immune parameters in patients with rheumatic and inflammatory disease receiving dietary supplementation of n-3 and n-6 fatty acids. Lipids 31, 243–247.Google Scholar
Kromann, N & Green, A (1980) Epidemiologic studies in the Upernavik district Greenland. Incidence of some chronic diseases 1950–1974. Acta Medica Scandinavica 208, 401–406.CrossRefGoogle ScholarPubMed
Leaf, A & Weber, PC (1988) Cardiovascular effects of n-3 fatty acids: medical progress. New England Journal of Medicine 318, 549–557.CrossRefGoogle Scholar
Lee, TH, Hoover, RL, Williams, JD, Sperling, RI, Ravalese, J, Spur, BW, Robinson, DR, Corey, EJ, Lewis, RA & Austen, KF (1985) Effect of dietary enrichment with eicosapentaenoic and docosahexaenoic acids on in vitro neutrophil and monocyte leukotriene generation and neutrophil function. New England Journal of Medicine 312, 1217–1224.CrossRefGoogle ScholarPubMed
Lee, TH, Sethi, T, Crea, AEG, Peters, W, Arm, JP, Horton, CE, Walport, MJ & Spur, W (1988) Characterization of leukotriene B3: comparison of its biological activities with leukotriene B4 and leukotriene B5 in complement receptor enhancement, lysozyme release and chemotaxis of human neutrophils. Clinical Science 74, 467–475.CrossRefGoogle ScholarPubMed
Lewis, RA, Lee, TH & Austen, KF (1986) Effects of omega-3 fatty acids on the generation of products of the 5-lipoxygenase pathway. In Health Effects of Polyunsaturated Fatty Acids in Seafoods, pp. 227–238 [Simopoulos, AP, editor]. Orlando, FL: Academic Press.Google Scholar
Liimatta, M, Towle, HC, Clarke, SD & Jump, DB (1994) Dietary polyunsaturated fatty acids interfere with the insulin/glucose activation of L-type pyruvate kinase gene transcription. Molecular Endocrinology 8, 1147–1153.Google ScholarPubMed
Loeschke, K, Ueberschaer, B, Pietsch, A, Gruber, E, Ewe, K, Wiebecke, B, Heldwein, W & Lorenz, R (1996) N-3 fatty acids only delay early relapse of ulcerative colitis in remission. Digestive Diseases and Sciences 41, 2087–2094.CrossRefGoogle ScholarPubMed
Mancuso, P, Whelan, J, DeMichele, SJ, Snider, CC, Guszcza, JA, Claycombe, KJ, Smith, GT, Gregory, TJ & Karlstad, MD (1997) Effects of eicosapentaenoic and gamma-linolenic acid on lung permeability and alveolar macrophage eicosanoid synthesis in endotoxic rats. Critical Care Medicine 25, 523–532.CrossRefGoogle ScholarPubMed
Martin, G, Schoonjans, K, Lefebvre, AM, Staels, B & Auwerx, J (1997) Coordinate regulation of the expression of the fatty acid transport protein and acyl-CoA synthetase genes by PPAR α, and PPAR γ, activators. Journal of Biological Chemistry 272, 28210–28217.CrossRefGoogle Scholar
Mascaro, C, Acosta, E, Ortiz, JA, Marrero, PF, Hegardt, FG & Haro, D (1998) Control of human muscle-type carnitine palmitoyltransferase I gene transcription by peroxisome proliferator-activated receptor. Journal of Biological Chemistry 273, 8560–8563.CrossRefGoogle ScholarPubMed
Mason, DW & Morris, PJ (1986) Effector mechanisms in allograft rejection. Annal Review of Immunology 4, 119–145.CrossRefGoogle ScholarPubMed
Mater, MK, Pan, D, Bergen, WG & Jump, DB (1998) Arachidonic acid inhibits lipogenic gene expression in 3T3-L adipocytes through a prostanoid pathway. Journal of Lipid Research 39, 1327–1334.CrossRefGoogle Scholar
Murray, MJ, Svingen, BA, Holman, RT & Yaksh, TL (1991) Effects of a fish oil diet on pigs’ cardiopulmonary response to bacteremia. Journal of Parenteral and Enteral Nutrition 15, 152–158.CrossRefGoogle ScholarPubMed
May, CL, Southworth, AJ & Calder, PC (1993) Inhibition of lymphocyte protein kinase C by unsaturated fatty acids. Biochemical and Biophysical Research Communications 195, 823–828.CrossRefGoogle ScholarPubMed
May, RM, Cooper, DKC, Du Toit, ED & Reichart, B (1990) Cytoimmunological monitoring after heart and heart lung transplantation. Journal of Heart Transplantation 9, 133–135.Google ScholarPubMed
Meydani, SN, Endres, S, Woods, MM, Goldin, BR, Soo, C & Morill-Labrode, A (1991) Oral n-3 fatty acid supplementation suppresses cytokine production and lymphocyte proliferation: comparison between young and older women. Journal of Nutrition 12, 547–555.CrossRefGoogle Scholar
Munro, JM (1993) Endothelial-leukocyte adhesive interactions in inflammatory diseases. European Heart Journal 14:72S–77S.Google ScholarPubMed
Peterson, J, Bihain, BE, Bengtsson-Olivecrona, G, Deckelbaum, RJ, Carpentier, YA & Olivecrona, T (1990) Fatty acid control of lipoprotein lipase: a link between energy metabolism and lipid transport. Proceedings of the National Academy of Sciences USA 87, 909–913.CrossRefGoogle ScholarPubMed
Pietsch, A, Weber, C, Goretzki, M, Weber, PC & Lorenz, RL (1995) N-3 but not n-6 fatty acids reduce the expression of the combined adhesion and scavanger receptor CD 36 in human monocytic cells. Cell Biochemistry and Function 13, 211–216.CrossRefGoogle ScholarPubMed
Rodriguez, JC, Gil-Gomez, B, Hegardt, FG & Haro, D (1994) Peroxisome proliferator-activated receptor mediates induction of the mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase gene by fatty acids. Journal of Biological Chemistry 269, 1867–1872.CrossRefGoogle ScholarPubMed
Sellmayer, A, Danesch, U & Weber, PC (1996) Effects of different polyunsaturated fatty acids on growth related early gene expression and cell growth. Lipids 31, 37–40.CrossRefGoogle ScholarPubMed
Shoda, R, Matseuda, K, Yamato, S & Umeda, N (1996) Epidemiologic analysis of Crohn disease in Japan: increased dietary intake of n-6 polyunsaturated fatty acids and animal protein relates to the increased incidence of Crohn’s disease in Japan. American Journal of Clinical Nutrition 63, 741–745.CrossRefGoogle Scholar
Simopoulos, AP (1991) Omega-3 fatty acids in health and disease and in growth and development. American Journal of Nutrition 54:438.Google ScholarPubMed
Sperling, RI, Robin, JL, Kylander, KA, Lee, TH, Lewis, RA & Austen, KF (1987) The effects of n-3 polyunsaturated fatty acids on the generation of platelet-activating acether by human monocytes. Journal of Immunology 139, 4186–4191.CrossRefGoogle ScholarPubMed
Stenson, WF, Cort, D, Rodgers, J, Burakoff, R, DeSchryver-Kecskemeti, K, Gramlich, TL & Beeken, W (1992) Dietary supplementation with fish oil in ulcerative colitis. Annals of Internal Medicine 116, 609–614.CrossRefGoogle ScholarPubMed
Tannenbaum, A (1942) The genesis and growth of tumors III. Effects of a high-fat diet. Cancer Research 2:468.Google Scholar
Thyssen, E, Turk, J, Bohrer, A & Stenson, WF (1996) Quantification of distinct molecular species of platelet activating factor in ulcerative colitis. Lipids 31:255S–259S.CrossRefGoogle ScholarPubMed
Tocher, DR, Bell, JG & Sargent, JR (1991) Incorporation of (3H) arachidonic and (14C) eicosapentaenoic acids into glycerophos-pholipids and thier metabolism via lipoxygenases in isolated brain cells from rainbow trout Oncorhynchus myciss. Journal of Neurochemistry 6, 2078–2085.CrossRefGoogle Scholar
Vilaseca, J, Salas, A, Guarner, F, Rodriguez, R & Malagelada, JR (1990) Participation of thromboxane and other eicosanoid synthesis in the course of experimental inflammatory colitis. Gastroenterology 98, 269–277.CrossRefGoogle ScholarPubMed
Weber, C, Erl, W, Pietsch, A, Danesch, U & Weber, PC (1995) Docosahexaenoic acid selectively attenuates induction of vascular cell adhesion molecule-1 and subsequent monocytic cell adhesion to human endothelial cells stimulated by tumor necrosis factor-alpha. Arteriosclerosis, Thrombosis and Vascular Biology 15, 622–628.CrossRefGoogle ScholarPubMed
Worgall, TS, Sturley, SL, Soo, T, Osborne, TF & Deckelbaum, RJ (1998) Polyunsaturated fatty acids decrease expression of promoters with sterol regulatory elements by decreasing levels of mature sterol regulatory element binding protein. Journal of Biological Chemistry 278, 25537–25540.CrossRefGoogle Scholar
Xu, J, Nakamura, T, Cho, HP & Clarke, SD (1999) Sterol regulatory element binding protein-1 expression is suppressed by dietary polyunsaturated fatty acids. Journal of Biological Chemistry 274, 23577–23588.CrossRefGoogle ScholarPubMed
Yagaloff, KA, Franco, L, Simko, B & Burghardt, B (1995) Essential fatty acids are antagonists of the leukotriene B4 receptor. Prostaglandins, Leukotrienes and Essential Fatty Acids 52, 293–297.CrossRefGoogle ScholarPubMed