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Proceedings of the Rank Forum on Vitamin D

  • S. A. Lanham-New (a1), J. L. Buttriss (a2), L. M. Miles (a2), M. Ashwell (a3), J. L. Berry (a4), B. J. Boucher (a5), K. D. Cashman (a6), C. Cooper (a7) (a8), A. L. Darling (a1), R. M. Francis (a9), W. D. Fraser (a10), C. P. G. M. de Groot (a11), E. Hyppönen (a12), M. Kiely (a6), C. Lamberg-Allardt (a13), H. M. Macdonald (a14), A. R. Martineau (a5), T. Masud (a15), A. Mavroeidi (a14), C. Nowson (a16), A. Prentice (a17), E. M. Stone (a18), S. Reddy (a19), R. Vieth (a20) and C. M. Williams (a21)...

Abstract

The Rank Forum on Vitamin D was held on 2nd and 3rd July 2009 at the University of Surrey, Guildford, UK. The workshop consisted of a series of scene-setting presentations to address the current issues and challenges concerning vitamin D and health, and included an open discussion focusing on the identification of the concentrations of serum 25-hydroxyvitamin D (25(OH)D) (a marker of vitamin D status) that may be regarded as optimal, and the implications this process may have in the setting of future dietary reference values for vitamin D in the UK. The Forum was in agreement with the fact that it is desirable for all of the population to have a serum 25(OH)D concentration above 25 nmol/l, but it discussed some uncertainty about the strength of evidence for the need to aim for substantially higher concentrations (25(OH)D concentrations>75 nmol/l). Any discussion of ‘optimal’ concentration of serum 25(OH)D needs to define ‘optimal’ with care since it is important to consider the normal distribution of requirements and the vitamin D needs for a wide range of outcomes. Current UK reference values concentrate on the requirements of particular subgroups of the population; this differs from the approaches used in other European countries where a wider range of age groups tend to be covered. With the re-emergence of rickets and the public health burden of low vitamin D status being already apparent, there is a need for urgent action from policy makers and risk managers. The Forum highlighted concerns regarding the failure of implementation of existing strategies in the UK for achieving current vitamin D recommendations.

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Corresponding author

*Corresponding author: Dr S. A. Lanham-New, fax +44 1483 686401, email s.lanham-new@surrey.ac.uk

References

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1Scientific Advisory Committee on Nutrition (2004) Advice on Fish Consumption: Benefits & Risks. London: TSO.
2Scientific Advisory Committee on Nutrition (2008) The Nutritional Wellbeing of the British Population. London: TSO.
3Lawson, M & Thomas, M (1999) Vitamin D concentrations in Asian children aged 2 years living in England: population survey. Br Med J 318, 28.
4Scientific Advisory Committee on Nutrition ACN (2007) Update on vitamin D: position statement by the Scientific Advisory Committee on Nutrition. http://www.sacn.gov.uk/pdfs/sacn_position_vitamin_d_2007_05_07.pdf.
5Department of Health (1991) Dietary Reference Values for Food Energy and Nutrients for the United Kingdom no. 41. London: HMSO.
6Department of Health (1998) Nutrition and Bone Health: With Particular Reference to Calcium and Vitamin D no. 49. London: The Stationary Office.
7Datta, S, Alfaham, M, Davies, DP, et al. (2002) Vitamin D deficiency in pregnant women from a non-European ethnic minority population – an interventional study. BJOG 109, 905908.
8Javaid, MK, Crozier, SR, Harvey, NC, et al. (2006) Maternal vitamin D status during pregnancy and childhood bone mass at age 9 years: a longitudinal study. Lancet 367, 3643.
9Hyppönen, E & Boucher, BJ (2010) Avoidance of vitamin D deficiency in pregnancy in the United Kingdom; the case for a unified approach in National policy. Br J Nutr 104, 309314.
10Finch, S, Doyle, W, Lowe, C, et al. (1998) National Diet and Nutrition Survey: People Aged 65 Years and Over. Report of the Diet and Nutrition Survey, vol. 1. London: The Stationery Office.
11Mocanu, V, Stitt, PA, Costan, AR, et al. (2009) Long-term effects of giving nursing home residents bread fortified with 125 μg (5000 IU) vitamin D3 per daily serving. Am J Clin Nutr 89, 11321137.
12Schoenmakers, I, Goldberg, GR & Prentice, A (2008) Abundant sunshine and vitamin D deficiency. Br J Nutr 99, 11711173.
13Hathcock, JN, Shao, A, Vieth, R, et al. (2007) Risk assessment for vitamin D. Am J Clin Nutr 85, 618.
14International Agency for Research on Cancer (2008) Vitamin D and Cancer. Working Group Report, vol. 5. Lyon: International Agency for Research on Cancer.
15Hyppönen, E & Power, C (2007) Hypovitaminosis D in British adults at age 45 y: nationwide cohort study of dietary and lifestyle predictors. Am J Clin Nutr 85, 860868.
16Lamberg-Allardt (2006) Vitamin D in foods and as supplements. Prog Biophys Mol Biol 92, 3338.
17Bischoff-Ferrari, HA, Willett, WC, Wong, JB, et al. (2009) Prevention of nonvertebral fractures with oral vitamin D and dose dependency: a meta-analysis of randomized controlled trials. Arch Intern Med 169, 551561.
18Tang, BMP, Eslick, GD, Nowson, C, et al. (2007) Use of calcium or calcium in combination with vitamin D supplementation to prevent fractures and bone loss in older people: a meta-analysis. Lancet 370, 657666.
19Avenell, A, Gillespie, W & Gillespie, L, et al. (2005) Vitamin D and vitamin D analogues for preventing fractures associated with involutional and post-menopausal osteoporosis. The Cochrane Database of Systematic Reviews, 2005, issue 3, CD000227. http://www.mrw.interscience.wiley.com/cochrane/clsysrev/articles/CD000227/frame.html.
20Boonen, S, Lips, P, Bouillon, R, et al. (2007) Need for additional calcium to reduce the risk of hip fracture with vitamin D supplementation: evidence from a comparative meta-analysis of randomized controlled trials. J Clin Endocrinol Metab 92, 14151423.
21FAO/WHO (2002) Human Vitamin and Mineral Requirements. FAO/WHO Non-series Publication. Report of a Joint FAO/WHO Expert Consultation. Rome: Food and Agriculture Organization.
22Mosekilde, L (2008) Vitamin D requirement and setting recommendation levels: long-term perspectives. Nutr Rev 66, S170S177.
23Ashwell, M, Stone, E, Stolte, H, et al. (2010) UK Food Standards Agency Workshop Report: an investigation of the relative contributions of diet and sunlight to vitamin D status. Br J Nutr (Epublication ahead of print version 4 June 2010).
24Prentice, A (2008) Vitamin D deficiency: a global perspective. Nutr Rev 66, S153S164.
25Trang, HM, Cole, DEC, Rubin, LA, et al. (1998) Evidence that vitamin D3 increases serum 25-hydroxyvitamin D more efficiently than does vitamin D2. Am J Clin Nutr 68, 854858.
26Holick, MF, Biancuzzo, RM, Chen, TC, et al. (2008) Vitamin D2 is as effective as vitamin D3 in maintaining circulating concentrations of 25-hydroxyvitamin D. J Clin Endocrinol Metab 93, 677681.
27Heaney, RP, Davies, KM, Chen, TC, et al. (2003) Human serum 25-hydroxycholecalciferol response to extended oral dosing with cholecalciferol. Am J Clin Nutr 77, 204210.
28Cashman, KD, Hill, TR, Lucey, AJ, et al. (2008) Estimation of the dietary requirement for vitamin D in healthy adults. Am J Clin Nutr 88, 15351542.
29Cashman, KD, Wallace, JMW, Horigan, G, et al. (2009) Estimation of the dietary requirement for vitamin D in free-living adults 64 y of age. Am J Clin Nutr 89, 19.
30Wallace, A, Gibson, S, de la Hunty, A, et al. (2010) Measurement of 25-hydroxyvitamin D in the clinical laboratory: current procedures, performance characteristics and limitations. Steroids 75, 477488.
31de la Hunty, A, Wallace, M, Gibson, S, et al. (2010) UK Food Standards Agency Workshop Consensus Report: the choice of method for measuring 25(OH)D to estimate vitamin D status for the UK National Diet and Nutrition Survey. Br J Nutr 104, 612619.
32Holick, M (2007) Vitamin D deficiency. NEJM 357, 266281.
33Hyppönen, E (2010) Vitamin D and increasing incidence of type 1 diabetes – evidence for an association? Diabetes Obes Metab 12, 737743.
34Hyppönen, E, Läärä, E, Reunanen, A, Järvelin, MR, et al. (2001) Intake of vitamin D and risk of type 1 diabetes: a birth-cohort study. Lancet 358, 15001503.
35De Boer, IH, Tinker, LF, Connelly, S, et al. (2008) Calcium plus vitamin D supplementation and the risk of incident diabetes in the Women's Health Initiative. Diabetes Care 31, 701707.
36Jorde, R & Figenschau, Y (2009) Supplementation with cholecalciferol does not improve glycaemic control in diabetic subjects with normal serum 25-hydroxyvitamin D levels. Eur J Nutr 48, 349354.
37Pittas, AG, Lau, J, Hu, FB, et al. (2007) The role of vitamin D and calcium in type 2 diabetes. A systematic review and meta-analysis. J Clin Endocrinol Metab 92, 20172029.
38Pittas, AG, Dawson-Hughes, B & Li, T (2006) Vitamin D and calcium intake in relation to type 2 diabetes in women. Diabetes Care 29, 650656.
39Wilkinson, RJ, Llewelyn, M, Toossi, Z, et al. (2000) Influence of vitamin D deficiency and vitamin D receptor polymorphisms on tuberculosis among Gujarati Asians in west London: a case–control study. Lancet 355, 618621.
40Liu, PT, Stenger, S, Li, H, et al. (2006) Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response. Science 312, 18741875.
41Martineau, AR, Wilkinson, KA, Newton, SM, et al. (2007) IFN-γ- and TNF-independent vitamin D-inducible human suppression of mycobacteria: the role of cathelicidin LL-37. J Immunol 178, 71907198.
42Martineau, AR, Wilkinson, RJ, Wilkinson, KA, et al. (2007) A single dose of vitamin D enhances immunity to mycobacteria. Am J Respir Crit Care Med 176, 208213.
43Martineau, AR, Nanzer, AM, Satkunam, KR, et al. (2009) Influence of a single oral dose of vitamin D2 on serum 25-hydroxyvitamin D concentrations in tuberculosis patients. Int J Tuberc Lung Dis 13, 119125.
44Mocanu, V, Stitt, PA, Costan, AR, et al. (2009) Long-term effects of giving nursing home residents bread fortified with 125 μg (5000 IU) vitamin D3 per daily serving. Am J Clin Nutr 89, 11321137.
45Giovannucci, E, Liu, Y, Hollis, BW, et al. (2008) 25-Hydroxyvitamin D and risk of myocardial infarction in men: a prospective study. Arch Intern Med 168, 11741180.
46Tuohimaa, P, Tenkanen, L, Ahonen, M, et al. (2004) Both high and low levels of blood vitamin D are associated with a higher prostate cancer risk: a longitudinal, nested case–control study in the Nordic countries. Int J Cancer 108, 104108.
47Grant, AM, Avenell, A, Campbell, MK, et al. (2005) Oral vitamin D3 and calcium for secondary prevention of low-trauma fractures in elderly people (Randomised Evaluation of Calcium Or vitamin D, RECORD): a randomised placebo-controlled trial. Lancet 365, 16211628.
48Dawson-Hughes, B, Heaney, RP, Holick, MF, et al. (2005) Estimates of optimal vitamin D status. Osteoporos Int 16, 713716.
49Hathcock, JN, Shao, A, Vieth, R, et al. (2007) Risk assessment for vitamin D. Am J Clin Nutr 85, 618.
50Avenell, A, Gillespie, WJ, Gillespie, LD, et al. (2009) Vitamin D and vitamin D analogues for preventing fractures associated with involutional and post-menopausal osteoporosis. The Cochrane Database of Systematic Reviews, 2009, issue 2, CD000227.
51Holick, MF (2004) Sunlight and vitamin D for bone health and prevention of autoimmune diseases, cancers, and cardiovascular disease. Am J Clin Nutr 80, 1678S1688S.
52Patel, S, Hyer, S & Barron, J (2007) Glomerular filtration rate is major determinant of the relationship between 25-hydroxy D and parathyroid hormone. Caclif Tissue Int 80, 221226.
53Cancer Council (Australia) (2008) How much sun is enough?http://www.cancer.org.au/File/Cancersmartlifestyle/Howmuchsunisenough.pdf.
54Expert Group on Vitamins and Minerals (2003) Safe Upper Levels for Vitamins and Minerals. London: Food Standards Agency.
55Scientific Committee on Food (2002) Opinion of the Scientific Committee on Food on the Tolerable Upper Intake Level of vitamin D. Brussels: European Commission.
56Institute of Medicine, Standing Committee on the Scientific Evaluation of Dietary Reference Intakes, Food and Nutrition Board (1997) Vitamin D, Chapter 7. In Dietary Reference Intake for Calcium, Phosphorus, Magnesium, Vitamin D, and Fluoride. Washington, DC: National Academy Press.
57Vieth, R, Chan, PC & Macfarlane, GD (2001) Efficacy and safety of vitamin D3 intake exceeding the lowest observed adverse effect level. Am J Clin Nutr 73, 288294.
58Jones, G (2008) Pharmacokinetics of vitamin D toxicity. Am J Clin Nutr 88, 582S586S.
59Pearce, SH & Cheetham, TD (2010) Diagnosis and management of vitamin D deficiency. Br Med J 340, b5664.
60Ruston, D, Hoare, J, Henderson, L, et al. (2004) The National Diet and Nutrition Survey: Adults Aged 19 to 64 Years. London: The Stationery Office.
61Doets, EL, de Wit, LS, Dhonukshe-Rutten, RAM, et al. (2008) Current micronutrient recommendations in Europe with special focus on vitamin A and vitamin D. Eur J Nutr 47, 1740.
62Henderson, L, Gregory, J, Swan, G, et al. (2002) The National Diet and Nutrition Survey: Adults Aged 19 to 64 years. London: The Stationery Office.
63Institute of Medicine (2005) Dietary Guidelines for Americans – Chapter 2. Adequate Nutrients Within Calorie Needs. http://www.health.gov/dietaryguidelines/dga2005/document/html/chapter2.htm (accessed September 9 2009).
64Gregory, J, Lowe, S, Bates, CJ, et al. (2000) National Diet and Nutrition Survey: Young People Aged 4–18 Years. Report of the Diet and Nutrition Survey, vol. 1. London: The Stationery Office.

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