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Postprandial factor VII metabolism: the effect of the R353Q and 10 bp polymorphisms

Published online by Cambridge University Press:  09 March 2007

Helen M. Roche ,
Irene L. Black ,
Enda Noone ,
Anne-Marie Tully ,
Alexander S. Whitehead  and
Michael J. Gibney
Helen M. Roche*
Affiliation:
Unit of Nutrition, Department of Clinical Medicine, Trinity Centre for Health Sciences, St. James's Hospital, James's Street, Dublin 8, Republic of Ireland
Irene L. Black
Affiliation:
Department of Genetics, Lincon Gate, Trinity College, Dublin 2, Republic of Ireland
Enda Noone
Affiliation:
Unit of Nutrition, Department of Clinical Medicine, Trinity Centre for Health Sciences, St. James's Hospital, James's Street, Dublin 8, Republic of Ireland
Anne-Marie Tully
Affiliation:
Unit of Nutrition, Department of Clinical Medicine, Trinity Centre for Health Sciences, St. James's Hospital, James's Street, Dublin 8, Republic of Ireland
Alexander S. Whitehead
Affiliation:
Department of Pharmacology, 153 Johnson Pavilion, 3620 Hamilton Walk, Philadelphia, PA 19104-6084, USA
Michael J. Gibney
Affiliation:
Unit of Nutrition, Department of Clinical Medicine, Trinity Centre for Health Sciences, St. James's Hospital, James's Street, Dublin 8, Republic of Ireland
*
*Corresponding author: Dr Helen M. Roche, fax +353 1 454 2043, email hmroche@tcd.ie
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Abstract

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Elevated levels of coagulation factor VII activity (FVIIc) are associated with increased risk of CHD. FVIIc is strongly determined by two polymorphisms (R353Q and 0/10 base pairs (bp)) and plasma triacylglycerol (TAG) concentrations. The Q and 10 bp polymorphisms show strong linkage disequilibrium and have been associated with lower levels of fasting FVII, but there has been little investigation of the effect of these genotypes on the postprandial FVII metabolism. The present study demonstrated that fasting activated factor VII (FVIIa) and factor VII antigen (FVIIag) levels were significantly lower in the heterozygotes carrying the Q and 10 bp alleles (n 12), than in the R/0 bp homozygotes (n 12) (43·0 (SE 4·8) v. 23·9 (SE 6·5) mU/ml and 85·7 (SE 5·4) v. 71·6 (SE 7·5) % respectively). During postprandial lipaemia there was a significant increase in FVIIa in R/0 bp homozygotes but not in the heterozygotes carrying the Q and 10 bp alleles. The proportion of FVIIa (FVIIa : FVIIag) increased in the homozygotes but not in the heterozygotes (2·04 (SE 0·35) v. 1·20 (SE 0·26) respectively). Therefore possession of the relatively common Q and 10 bp alleles is not associated with postprandial activation of FVII, which may in turn have a protective effect against CHD.

Keywords

Factor VIITriacylglycerolsGenetic polymorphism
Type
Short Communication
Information
British Journal of Nutrition , Volume 83 , Issue 5 , May 2000 , pp. 467 - 472
Copyright
Copyright © The Nutrition Society 2000

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