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Pharmacokinetic disposition in sheep of various vitamin E preparations given orally or intravenously

Published online by Cambridge University Press:  09 March 2007

M. Hidiroglou  and
K. Karpinski
M. Hidiroglou
Affiliation:
Animal Research Centre, Agriculture Canada, Ottawa K1A OC6, Canada
K. Karpinski
Affiliation:
Food Directorate, Health and Welfare Canada, Tower B, Place Vanier, Vanier, Ontario KIA 1B8, Canada
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Abstract

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1. Increases in plasma tocopherol concentrations were compared in sheep after a single oral administration of (per kg body-weight): 67 mg D- and 91 mg DL-epimers of α-tocopherol, and 74 mg D- and 100 mg DL-epimers of α-tocopheryl acetate, or intravenous administration of DL-α-tocopherol and DL-epimers of DL-α-tocopheryl acetate.

2. The results showed that biological availability was higher after D-α-tocopherol dosing than after the other forms. Intravenous administration of D-α-tocopherol acetate was a more effective way of dosing in sheep than equivalent intravenous amounts of DL-α-tocopheryl acetate or DL-α-tocopherol.

Type
Research Article
Information
British Journal of Nutrition , Volume 59 , Issue 3 , May 1988 , pp. 509 - 518
Copyright
Copyright © The Nutrition Society 1988

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