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A network biology model of micronutrient related health

  • Ben van Ommen (a1), Susan Fairweather-Tait (a2), Andreas Freidig (a1), Alwine Kardinaal (a1), Augustin Scalbert (a3) and Suzan Wopereis (a1)...

Abstract

Micronutrients are involved in specific biochemical pathways and have dedicated functions in the body, but they are also interconnected in complex metabolic networks, such as oxidative-reductive and inflammatory pathways and hormonal regulation, in which the overarching function is to optimise health. Post-genomic technologies, in particular metabolomics and proteomics, both of which are appropriate for plasma samples, provide a new opportunity to study the metabolic effects of micronutrients in relation to optimal health. The study of micronutrient-related health status requires a combination of data on markers of dietary exposure, markers of target function and biological response, health status metabolites, and disease parameters. When these nutrient-centred and physiology/health-centred parameters are combined and studied using a systems biology approach with bioinformatics and multivariate statistical tools, it should be possible to generate a micronutrient phenotype database. From this we can explore external factors that define the phenotype, such as lifestage and lifestyle, and the impact of genotype, and the results can also be used to define micronutrient requirements and provide dietary advice. New mechanistic insights have already been developed using biological network models, for example genes and protein-protein interactions in the aetiology of type 2 diabetes mellitus. It is hoped that the challenge of applying this approach to micronutrients will, in time, result in a change from micronutrient oriented to a health oriented views and provide a more holistic understanding of the role played by multiple micronutrients in the maintenance of homeostasis and prevention of chronic disease, for example through their involvement in oxidation and inflammation.

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Corresponding author

*Corresponding author: Ben van Ommen, fax +31 306944989, email ben.vanommen@tno.nl

References

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1International Life Sciences Institute 2005, http://europe.ilsi.org/activities/ecprojects/PASSCLAIM/.
2Scientific Advisory Committee on Nutrition 2002, http://www.sacn.gov.uk/pdfs/sacn_02_18.pdf.
3Pappa, HM, Grand, RJ & Gordon, CM (2006) Report on the vitamin D status of adult and pediatric patients with inflammatory bowel disease and its significance for bone health and disease. Inflamm Bowel Dis 12, 11621174.
4Zhang, X, Yap, Y, Wei, D, Chen, G & Chen, F (2008) Novel omics technologies in nutrition research. Biotechnol Adv 26, 169176.
5Kussmann, M, Raymond, F & Affolter, M (2006) OMICS-driven biomarker discovery in nutrition and health. J Biotechnol 124, 758787.
6van Ommen, B (2004) Nutrigenomics: exploiting systems biology in the nutrition and health arenas. Nutrition 20, 48.
7Young, VR (2003) Trace element biology: the knowledge base and its application for the nutrition of individuals and populations. J Nutr 133, 1581S1587S.
8Zeisel, SH, Freake, HC, Bauman, DE, et al. (2005) The nutritional phenotype in the age of metabolomics. J Nutr 135, 16131616.
9Dikiy, A, Novoselov, SV, Fomenko, DE, et al. (2007) SelT, SelW, SelH, and Rdx12: genomics and molecular insights into the functions of selenoproteins of a novel thioredoxin-like family. Biochemistry 46, 68716882.
10Papp, LV, Lu, J, Holmgren, A & Khanna, KK (2007) From selenium to selenoproteins: synthesis, identity, and their role in human health. Antioxid Redox Signal 9, 775806.
11Bai, C, Matsui, E, Ohnishi, H, Kimata, K, Kasahara, K, Kaneko, H, Kato, Z, Fukao, T & Kondo, N (2008) A novel polymorphism, E254K, in the 5-lipoxygenase gene associated with bronchial asthma. Int J Mol Med 21, 139144.
12Fowler, SJ, Hall, IP, Wilson, AM, Wheatley, AP & Lipworth, BJ (2002) 5-Lipoxygenase polymorphism and in-vivo response to leukotriene receptor antagonists. Eur J Clin Pharmacol 58, 187190.
13Kim, SH, Bae, JS, Suh, CH, Nahm, DH, Holloway, JW & Park, HS (2005) Polymorphism of tandem repeat in promoter of 5-lipoxygenase in ASA-intolerant asthma: a positive association with airway hyperresponsiveness. Allergy 60, 760765.
14Foster, CB, Aswath, K, Chanock, SJ, McKay, HF & Peters, U (2006) Polymorphism analysis of six selenoprotein genes: support for a selective sweep at the glutathione peroxidase 1 locus (3p21) in Asian populations. BMC Genet 7, 56.
15Villette, S, Kyle, JA, Brown, KM, Pickard, K, Milne, JS, Nicol, F, Arthur, JR & Hesketh, JE (2002) A novel single nucleotide polymorphism in the 3′ untranslated region of human glutathione peroxidase 4 influences lipoxygenase metabolism. Blood Cells Mol Dis 29, 174178.
16Jozsi, AC, Dupont-Versteegden, EE, Taylor-Jones, JM, Evans, WJ, Trappe, TA, Campbell, WW & Peterson, CA (2000) Aged human muscle demonstrates an altered gene expression profile consistent with an impaired response to exercise. Mech Ageing Dev 120, 4556.
17Ennezat, PV, Malendowicz, SL, Testa, M, Colombo, PC, Cohen-Solal, A, Evans, T & LeJemtel, TH (2001) Physical training in patients with chronic heart failure enhances the expression of genes encoding antioxidative enzymes. J Am Coll Cardiol 38, 194198.
18Palazzetti, S, Rousseau, AS, Richard, MJ, Favier, A & Margaritis, I (2004) Antioxidant supplementation preserves antioxidant response in physical training and low antioxidant intake. Br J Nutr 91, 91100.
19Zalewski, PD (2006) Zinc metabolism in the airway: basic mechanisms and drug targets. Curr Opin Pharmacol 6, 237243.
20Zhang, J, Svehlíková, V, Bao, Y, Howie, AF, Beckett, GJ & Williamson, G (2003) Synergy between sulforaphane and selenium in the induction of thioredoxin reductase 1 requires both transcriptional and translational modulation. Carcinogenesis 24, 497503.
21Kamanna, VS & Kashyap, ML (2000) Mechanism of action of niacin on lipoprotein metabolism. Curr Atheroscler Rep 2, 3646.
22Powers, HJ (2003) Riboflavin (vitamin B-2) and health. Am J Clin Nutr 77, 13521360.
23Newman, JW, Kaysen, GA, Hammock, BD & Shearer, GC (2007) Proteinuria increases oxylipid concentrations in VLDL and HDL but not LDL particles in the rat. J Lipid Res 48, 17921800.
24Devaraj, S, Tang, R, dams-Huet, B, Harris, A, Seenivasan, T, de Lemos, JA & Jialal, I (2007) Effect of high-dose alpha-tocopherol supplementation on biomarkers of oxidative stress and inflammation and carotid atherosclerosis in patients with coronary artery disease. Am J Clin Nutr 86, 13921398.
25Devaraj, S, Leonard, S, Traber, MG & Jialal, I (2008) Gamma-tocopherol supplementation alone and in combination with alpha-tocopherol alters biomarkers of oxidative stress and inflammation in subjects with metabolic syndrome. Free Radic Biol Med 44, 12031208.
26Kaddurah-Daouk, R, Kristal, BS & Weinshilboum, RM (2008) Metabolomics: a global biochemical approach to drug response and disease. Ann Rev Pharmacol Toxicol 48, 653683.
27Han, X (2007) An update on lipidomics: progress and application in biomarker and drug development. Curr Opin Mol Ther 9, 586591.
28Wishart, DS, Tzur, D, Knox, C, et al. (2007) HMDB: the Human Metabolome Database. Nucleic Acids Res 35, D521D526.
29Bonney, GK, Craven, RA, Prasad, R, Melcher, AF, Selby, PJ & Banks, RE (2008) Circulating markers of biliary malignancy: opportunities in proteomics? Lancet Oncol 9, 149158.
30Liu, XP, Shen, J, Li, ZF, Yan, L & Gu, J (2006) A serum proteomic pattern for the detection of colorectal adenocarcinoma using surface enhanced laser desorption and ionization mass spectrometry. Cancer Invest 24, 747753.
31Ray, S, Britschgi, M, Herbert, C, et al. (2007) Classification and prediction of clinical Alzheimer's diagnosis based on plasma signaling proteins. Nat Med 13, 13591362.
32Han, JDJ (2008) Understanding biological functions through molecular networks. Cell Res 18, 224237.
33Liu, M, Liberzon, A, Kong, SW, Lai, WR, Park, PJ, Kohane, IS & Kasif, S (2007) Network-based analysis of affected biological processes in type 2 diabetes models. PLoS Genet 3, e96.
34Nikiforova, VJ & Willmitzer, L (2007) Network visualization and network analysis. EXS 97, 245275.
35Chiplonkar, SA, Agte, VV, Tarwadi, KV, Paknikar, KM & Diwate, UP (2004) Micronutrient deficiencies as predisposing factors for hypertension in lacto-vegetarian Indian adults. J Am Coll Nutr 23, 239247.
36Gross, MD (2005) Vitamin D and calcium in the prevention of prostate and colon cancer: new approaches for the identification of needs. J Nutr 135, 326331.
37Paolini, G, Shapland, R, van Hoorn, W, Mason, J & Hopkins, A (2006) Global mapping of pharmacological space. Nat Biotechnol 24, 805815.
38Lamb, J (2007) The connectivity map: a new tool for biomedical research. Nat Rev Cancer 7, 904960.
39German, JB, Watkins, SM & Fay, LB (2005) Metabolomics in practice: emerging knowledge to guide future dietetic advice toward individualized health. J Am Diet Assoc 105, 14251432.
40Omenn, GS, Aebersold, R & Paik, YK (2007) HUPO Plasma Proteome Project 2007 Workshop Report. Mol Cell Proteomics 6, 22522253.
41Zarin, DA & Tse, T (2008) Medicine. Moving toward transparency of clinical trials. Science 319, 13401342.
42van der Linden, IJM, Afman, LA, Heil, SG & Blom, HJ (2006) Genetic variation in genes of folate metabolism and neural-tube defect risk. Proc Nutr Soc 65, 204215.
43Montero, R, Pineda, M, Aracil, A, Vilaseca, MA, Briones, P, Sánchez-Alcázar, JA, Navas, P & Artuch, R (2007) Clinical, biochemical and molecular aspects of cerebellar ataxia and Coenzyme Q10 deficiency. Cerebellum 6, 118122.
44Huster, D & Lutsenko, S (2007) Wilson disease: not just a copper disorder. Analysis of a Wilson disease model demonstrates the link between copper and lipid metabolism. Mol Biosyst 3, 816824.
45Kohlmeier, M, da Costa, KA, Fischer, LM & Zeisel, SH (2005) Genetic variation of folate-mediated one-carbon transfer pathway predicts susceptibility to choline deficiency in humans. Proc Natl Acad Sci USA 102, 1602516030.
46Stover, PJ (2006) Influence of human genetic variation on nutritional requirements. Am J Clin Nutr 83, 436S442S.
47Bouwens, M, Afman, LA & Müller, M (2007) Fasting induces changes in peripheral blood mononuclear cell gene expression profiles related to increases in fatty acid beta-oxidation: functional role of peroxisome proliferator activated receptor alpha in human peripheral blood mononuclear cells. Am J Clin Nutr 86, 15151523.
48Chen, C, Shah, YM, Morimura, K, Krausz, KW, Miyazaki, M, Richardson, TA, Morgan, ET, Ntambi, JM, Idle, JR & Gonzalez, FJ (2008) Metabolomics reveals that hepatic stearoyl-CoA desaturase 1 downregulation exacerbates inflammation and acute colitis. Cell Metab 7, 135147.
49Fuchs, D, Vafeiadou, K, Hall, WL, Daniel, H, Williams, CM, Schroot, JH & Wenzel, U (2007) Proteomic biomarkers of peripheral blood mononuclear cells obtained from postmenopausal women undergoing an intervention with soy isoflavones. Am J Clin Nutr 86, 13691375.
50Kleemann, R, Verschuren, L, van Erk, MJ, et al. (2007) Atherosclerosis and liver inflammation induced by increased dietary cholesterol intake: a combined transcriptomics and metabolomics analysis. Genome Biol 8, R200.
51Walsh, MC, Brennan, L, Malthouse, JP, Roche, HM & Gibney, MJ (2006) Effect of acute dietary standardization on the urinary, plasma, and salivary metabolomic profiles of healthy humans. Am J Clin Nutr 84, 531539.
52Walsh, MC, Brennan, L, Pujos-Guillot, E, Sébédio, JL, Scalbert, A, Fagan, A, Higgins, DG & Gibney, MJ (2007) Influence of acute phytochemical intake on human urinary metabolomic profiles. Am J Clin Nutr 86, 16871693.
53Ghazalpour, A, Doss, S, Yang, X, Aten, J, Toomey, EM, Van Nas, A, Wang, S, Drake, TA & Lusis, AJ (2004) Thematic review series: the pathogenesis of atherosclerosis. Toward a biological network for atherosclerosis. J Lipid Res 45, 17931805.
54Geier, F, Timmer, J & Fleck, C (2007) Reconstructing gene-regulatory networks from time series, knock-out data, and prior knowledge. BMC Systems Biology 1, 11.

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