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A micronised, dispersible ferric pyrophosphate with high relative bioavailability in man

Published online by Cambridge University Press:  09 March 2007

Meredith C. Fidler ,
Thomas Walczyk ,
Lena Davidsson ,
Christophe Zeder ,
Noboru Sakaguchi ,
Lekh R. Juneja  and
Richard F. Hurrell
Meredith C. Fidler
Affiliation:
Laboratory for Human Nutrition, Institute of Food Science and Nutrition, Swiss Federal Institute of Technology (ETH) Zurich, PO Box 474/Seestrasse 72, CH-8803 Rüschlikon, Switzerland
Thomas Walczyk
Affiliation:
Laboratory for Human Nutrition, Institute of Food Science and Nutrition, Swiss Federal Institute of Technology (ETH) Zurich, PO Box 474/Seestrasse 72, CH-8803 Rüschlikon, Switzerland
Lena Davidsson*
Affiliation:
Laboratory for Human Nutrition, Institute of Food Science and Nutrition, Swiss Federal Institute of Technology (ETH) Zurich, PO Box 474/Seestrasse 72, CH-8803 Rüschlikon, Switzerland
Christophe Zeder
Affiliation:
Laboratory for Human Nutrition, Institute of Food Science and Nutrition, Swiss Federal Institute of Technology (ETH) Zurich, PO Box 474/Seestrasse 72, CH-8803 Rüschlikon, Switzerland
Noboru Sakaguchi
Affiliation:
Nutritional Foods Division, Taiyo Kagaku, 9-5 Akahori-Shinmachi, Yokkaichi, Mie 510-0825, Japan
Lekh R. Juneja
Affiliation:
Nutritional Foods Division, Taiyo Kagaku, 9-5 Akahori-Shinmachi, Yokkaichi, Mie 510-0825, Japan
Richard F. Hurrell
Affiliation:
Laboratory for Human Nutrition, Institute of Food Science and Nutrition, Swiss Federal Institute of Technology (ETH) Zurich, PO Box 474/Seestrasse 72, CH-8803 Rüschlikon, Switzerland
*
*Corresponding author: Dr Lena Davidsson, fax +41 1 704 57 10, email lena.davidsson@ilw.agrl.ethz.ch
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Abstract

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Ferric pyrophosphate is a water-insoluble Fe compound used to fortify infant cereals and chocolate-drink powders as it causes no organoleptic changes to the food vehicle. However, it is only of low absorption in man. Recently, an innovative ferric pyrophosphate has been developed (Sunactive Fe™) based on small-particle-size ferric pyrophosphate (average size 0·3 μm) mixed with emulsifiers, so that it remains in suspension in liquid products. The aim of the present studies was to compare Fe absorption of micronised, dispersible ferric pyrophosphate (Sunactive Fe™) with that of ferrous sulfate in an infant cereal and a yoghurt drink. Two separate Fe absorption studies were made in adult women (ten women/study). Fe absorption was based on the erythrocyte incorporation of stable isotopes (57Fe and 58Fe) 14 d after the intake of labelled test meals of infant cereal (study 1) or yoghurt drink (study 2). Each test meal was fortified with 5 mg Fe as ferrous sulfate or micronised, dispersible ferric pyrophosphate. Results are presented as geometric means. There was no statistically significant difference between Fe absorption from micronised, dispersible ferric pyrophosphate- and ferrous sulfate-fortified infant cereal (3·4 and 4·1 % respectively; P=0·24) and yoghurt drink (3·9 and 4·2 % respectively; P=0·72). The results of the present studies show that micronised, dispersible ferric pyrophosphate is as well absorbed as ferrous sulfate in adults. The high relative Fe bioavailability of micronised, dispersible ferric pyrophosphate indicates the potential usefulness of this compound for food fortification.

Keywords

Iron absorptionIron fortificationFerric pyrophosphateSunactive Fe™
Type
Research Article
Information
British Journal of Nutrition , Volume 91 , Issue 1 , January 2004 , pp. 107 - 112
Copyright
Copyright © The Nutrition Society 2004

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