Hostname: page-component-848d4c4894-pjpqr Total loading time: 0 Render date: 2024-06-21T18:47:57.170Z Has data issue: false hasContentIssue false
  • English
  • Français

Metabolism of riboflavin:reduction of 7,s-dimethyl-10-formylmethylisoalloxazine by an enzyme in liver

Published online by Cambridge University Press:  24 July 2007

D. W. West  and
E. C. Owen
D. W. West
Affiliation:
Biochemistry Department, Hannah Research Institute, Ayr KA6 5HL
E. C. Owen
Affiliation:
Biochemistry Department, Hannah Research Institute, Ayr KA6 5HL
Rights & Permissions [Opens in a new window]

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

1. The riboflavin metabolite, 7,8-dimethyl-10-formylmethylisoalloxazine, has been shown to be reduced to the corresponding alcohol, 7,8-dimethyl-10-(2′-hydroxyethyl)isoalloxazine, by an enzyme present in the soluble fraction of liver and kidney.

2. The enzyme is present in these organs in a number of species but is especially prevalent in the tissues of ruminants. It appears to be different from the normal hepatic alcohol dehydrogenase in that it uses NADPH rather than NADH as cofactor.

Type
Research Article
Information
British Journal of Nutrition , Volume 29 , Issue 1 , January 1973 , pp. 43 - 50
Copyright
Copyright © The Nutrition Society 1973

References

REFERENCES

Ballard, F. J., Hanson, R. W. & Kronfeld, D. S. (1969). Fedn Proc. Fedn Am. Socs exp. Biol. 28, 218.Google Scholar
DeMoss, R. D. (1955). Meth. Enzym. 1, 504.CrossRefGoogle Scholar
Fall, H. H. & Petering, H. G. (1956). J. Am. chem. Soc. 78, 377.CrossRefGoogle Scholar
Owen, E. C. (1962). Proc. int. Congr. Fd Sci. I. London Vol. 3, p. 669.Google Scholar
Owen, E. C. & West, D. W. (1968). J. chem. Soc. C p. 34.CrossRefGoogle Scholar
Owen, E. C. & West, D. W. (1970). Br. J. Nutr. 24, 45.CrossRefGoogle Scholar
Owen, E. C., West, D. W. & Coates, M. E. (1970). Br. J. Nutr. 24, 259.CrossRefGoogle Scholar
Sable, H. Z. (1952). Biochim. biophys. Acta 8, 687.CrossRefGoogle Scholar
Suelter, C. H. & Metzler, D. E. (1960). Biochim. biophys. Acta 44, 23.CrossRefGoogle Scholar
Stafford, H. A. & Vennesland, B. (1953). Archs Biochem. Biophys. 44, 404.CrossRefGoogle Scholar