Hostname: page-component-77c89778f8-5wvtr Total loading time: 0 Render date: 2024-07-16T20:28:42.996Z Has data issue: false hasContentIssue false
  • English
  • Français

Messenger RNA levels of plasma proteins following fasting

Published online by Cambridge University Press:  09 March 2007

Felice A. De Jong ,
Geoffrey J. Howlett  and
Gerhard Schreiber
Felice A. De Jong
Affiliation:
Biotechnology Australia Pty Ltd, Roseville, NSW 2069, Australia
Geoffrey J. Howlett
Affiliation:
Biotechnology Australia Pty Ltd, Roseville, NSW 2069, Australia
Gerhard Schreiber
Affiliation:
Biotechnology Australia Pty Ltd, Roseville, NSW 2069, Australia
Rights & Permissions [Opens in a new window]

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

1. The effect of fasting on hepatic mRNA levels of seven plasma proteins was examined in the rat.

2. The levels of mRNA were measured directly in cytoplasmic extracts by hybridization to specific 32P-labelled cDNA probes.

3. Following a 48 h period of fasting, the mRNA levels of apolipoprotein E, apolipoprotein A-IV, albumin, transferrin, and transthyretin decreased by 15–30%, while apolipoprotein A-II decreased by 78% compared with non-fasted control rats. The mRNA for apolipoprotein A-I increased by 33%.

4. These findings suggest that mRNA levels in the liver following fasting are regulated independently and variations in these levels may be due to differences in transcription rates or mRNA stability.

Type
General Nutrition papers
Information
British Journal of Nutrition , Volume 59 , Issue 1 , January 1988 , pp. 81 - 86
Copyright
Copyright © The Nutrition Society 1988

References

Aldred, A. R., Howlett, G. J. & Schreiber, G. (1984). Biochemical Biophysical Research Communications 122, 960–965.CrossRefGoogle Scholar
Burton, D. N., Collins, J. M., Kernan, A. L. & Porter, J. W. (1969). Journal of Biological Chemistry 244, 4510–4516.CrossRefGoogle Scholar
de Jong, F. A., Howlett, G., Aldred, A. R., Fidge, N. & Schreiber, G. (1984). Biochemical Biophysical Research Communications 119, 657–662.CrossRefGoogle Scholar
Dickson, P. W., Howlett, G. J. & Schreiber, G. (1985). Journal of Biological Chemistry 260, 8214–8219.CrossRefGoogle Scholar
Elkeles, R. S. & Hambley, J. (1977). Diabetes 26, 58–60.CrossRefGoogle ScholarPubMed
Enwonwu, C. O. & Munro, H. N. (1970). Archives of Biochemistry and Biophysics 138, 532–539.CrossRefGoogle Scholar
Felding, P. & Fex, G. (1983). Acta Physiologica Scandinavica 117, 377–383.CrossRefGoogle Scholar
Goldman, J. J., Back, D. W. & Goodridge, A. G. (1985). Journal of Biological Chemistry 260, 4404–4408.CrossRefGoogle Scholar
Guo-Fen, T., de Jong, F., Apostolopoulos, J., Nagashima, M., Fidge, N., Schreiber, G. & Howlett, G. (1987). Inflammation 11, 241–251.CrossRefGoogle Scholar
Henderson, A. R. (1970). Biochemical Journal 120, 205–214.CrossRefGoogle Scholar
Henshaw, E. C. (1968). Journal of Molecular Biology 36, 401–411.CrossRefGoogle Scholar
Henshaw, E. C., Hirsch, C. A., Morton, B. E. & Hiatt, H. H. (1971). Journal of Biological Chemistry 246, 436–446.CrossRefGoogle Scholar
Hirsch, C. A. & Hiatt, H. H. (1966). Journal of Biological Chemistry 241, 5936–5940.CrossRefGoogle Scholar
Hogan, B. L. M. & Korner, A. (1968). Biochimica et Biophysica Acta 169, 129–138.CrossRefGoogle Scholar
Howard, G., Chitpatima, S. T., Feldhoff, R. C. & Geoghegan, T. E. (1986). Proceedings of the Society, for Experimental Biology and Medicine 181, 312–317.CrossRefGoogle Scholar
Jahn, C. E., Osborne, J. C. Jr., Schaefer, E. J. & Brewer, H. B. Jr (1983). European Journal of Biochemistry 131, 25–29.CrossRefGoogle Scholar
Kirsch, R., Frith, L., Black, E. & Hoffenberg, R. (1968). Nature 217, 578–579.CrossRefGoogle Scholar
Kosterlitz, H. W. (1947). Journal of Physiology 106, 194–210.CrossRefGoogle Scholar
Laird, A. K., Barton, A. D. & Nygaard, O. (1955). Experimental Cell Research 9, 523–540.CrossRefGoogle Scholar
Lee, S. Y., Krsmanovic, V. & Brawerman, G. (1971). Biochemistry 10, 895–900.Google Scholar
McNurlan, M. A., Tomkins, A. M. & Garlick, P. J. (1972). Biochemistry Journal 178, 373–379.CrossRefGoogle Scholar
Maniatis, T., Fritsch, E. F. & Sambrook, J. (1982). In Molecular Cloning, pp. 109–112 [Maniatis, T., Fritsch, E. F. and Sambrook, J., editors]. New York: Cold Spring Harbor Laboratory.Google Scholar
Murty, C. N. & Sidransky, H. (1972). Biochimica et Biophysica Acta 262 328–335.CrossRefGoogle Scholar
Murty, C. N., Verney, E. & Sidransky, H. (1976). Laboratory Investigation 34, 77–85.Google Scholar
Noll, H., Staehelin, T. & Wettstein, F. O. (1963). Nature 198, 632–638.CrossRefGoogle Scholar
Pain, V. M., Clemens, M. J. & Garlick, P. J. (1978). Biochemical Journal 172, 129–135.CrossRefGoogle Scholar
Princen, J. M. G., Mol-Backx, G. P. B. M. & Yap, S. H. (1983). Annals of Nutrition and Metabolism 27, 182–193.CrossRefGoogle Scholar
Ramsey, J. C. & Steele, W. J. (1976). Biochimica et Biophysica Acta 447, 312–318.CrossRefGoogle Scholar
Reid, I. M., Very, E. & Sidransky, H. (1970). Journal of Nutrition 100, 1149–1156.CrossRefGoogle Scholar
Rothschild, M. A., Oratz, M., Mongelli, J. & Schreiber, S. S. (1968). Journal of Clinical Investigation 47, 2591–2599.CrossRefGoogle Scholar
Schreiber, G., Aldred, A. R., Thomas, T., Birch, H. E., Dickson, P. W., Guo-Fen., , Heinrich, P. C., Howlett, G. J., de Jong, F. A. & Mitchell, A. (1986). Inflammation 10, 59–66.CrossRefGoogle ScholarPubMed
Sonenstein, G. E. & Brawerman, G. (1977). European Journal of Biochemistry 73, 307–312.CrossRefGoogle Scholar
Spirin, A. S. (1966). In Current Topics in Developmental Biology, vol. I, p. 1 [Monroy, A. and Moscana, A. A., editors]. New York: Academic Press.Google Scholar
Staehelin, T., Wettstein, F. O. & Noll, H. (1963). Science 140, 80–83.CrossRefGoogle Scholar
Thomas, P. S. (1980). Proceedings of the National Academy of Science, U.S.A. 77, 5201–5205.CrossRefGoogle Scholar
Trakatellis, A. C., Axelrod, A. E. & Montjar, M. (1964). Journal of Biological Chemistry 239, 4237–4244.CrossRefGoogle Scholar
van Venrooij, W. J. W., Henshaw, E. C. & Hirsch, C. A. (1972). Biochimica et Biophysica Acta 259, 127–137.CrossRefGoogle Scholar
Vaughan, M. H., Pawlowski, P. J. & Forchhammer, T. (1971). Proceedings of the National Academy of Science, U.S.A. 68, 2057–2061.CrossRefGoogle Scholar
Vesley, J. & Cihak, A. (1970). Biochimica et Biophysica Acta 204, 614–616.CrossRefGoogle Scholar
Warner, J. R., Rich, A. & Hall, C. E. (1962). Science 138, 1399–1403.CrossRefGoogle Scholar
Webb, T. E., Blobel, G. & Potter, V. R. (1966). Cancer Research 26, 253–257.Google Scholar
Wilson, S. H., Hill, H. Z. & Hoagland, M. B. (1967); Biochemical Journal 103, 567–572.CrossRefGoogle Scholar
Wilson, S. H. & Hoagland, M. B. (1967). Biochemical Journal 103, 556–566.CrossRefGoogle Scholar
Yap, S. H. & Hafkenscheid, J. C. M. (1981). Annals of Nutrition and Metabolism 25, 158–164.CrossRefGoogle Scholar
Yap, S. H., Strair, R. K. & Shafritz, D. A. (1978). Journal of Biological Chemistry 253, 4944–4950.CrossRefGoogle Scholar