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Interactions between protein and vegetable oils in the maternal diet determine the programming of the insulin axis in the rat

  • Christopher A. Maloney (a1), Christina Lilley (a1), Alicja Czopek (a1), Susan M. Hay (a1) and William D. Rees (a1)...

Abstract

The available evidence suggests that metabolic control mechanisms are programmed early in life. Previous studies of pregnant rats fed low-protein diets have suggested that the vegetable oils used in the experimental diets influence the outcome. The present study investigated the offspring of female rats fed semi-synthetic diets containing either 180 or 90 g casein/kg with 70 g/kg (w/w) of either corn oil or soya oil during gestation. During lactation, the dams received stock diet, and the offspring were subsequently weaned onto the stock diet. The offspring of dams fed the low-protein diets were smaller at birth. At 25 weeks of age, the offspring were subjected to an oral glucose tolerance test. In the offspring of dams fed the diet containing soya oil, the area under the insulin curve was affected by the protein content of the maternal diet. There was no effect of protein on the area under the insulin curve in the offspring of dams fed the diet prepared with corn oil. There were no differences in plasma glucose concentrations. The levels of mRNA for acetyl-CoA carboxylase-1 in the livers of female offspring were affected by the protein and oil content of the maternal diet. The level of carnitine palmitoyl transferase mRNA was affected by the protein content of the maternal diet. The present study suggests that PUFA in the maternal diet can interact with protein metabolism to influence the development of the offspring. This may involve the higher content of α-linolenic acid in soya oil compared with corn oil.

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Corresponding author

*Corresponding author: Dr William D. Rees, fax +44 (0) 1224 716622, email wdr@rri.sari.ac.uk

References

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Bonnevie-Nielsen, V (1980) Experimental diets affect pancreatic insulin and glucagon differently in male and female mice. Metabolism 29, 386391.
Burdge, GC, Dunn, RL, Wootton, SA & Jackson, AA (2002) Effect of reduced dietary protein intake on hepatic and plasma essential fatty acid concentrations in the adult female rat: effect of pregnancy and consequences for accumulation of arachidonic and docosahexaenoic acids in fetal liver and brain. Br J Nutr 88, 379387.
Cardot, P, Chambaz, J, Thomas, G, Rayssiguier, Y & Bereziat, G (1987) Essential fatty acid deficiency during pregnancy in the rat: influence of dietary carbohydrates. J Nutr 117, 15041513.
Christie, WW (1990) Preparation of methyl esters. 1. Lipid Technol 2, 4849.
D'Alessandro, ME, Lombardo, YB & Chicco, A (2002) Effect of dietary fish oil on insulin sensitivity and metabolic fate of glucose in the skeletal muscle of normal rats. Ann Nutr Metab 46, 114120.
Desai, M, Crowther, NJ, Lucas, A & Hales, CN (1996) Organ-selective growth in the offspring of protein-restricted mothers. Br J Nutr 76, 591603.
Erhuma, AM, Langley-Evans, SC & Bennett, AJ (In the Press) Exposure to a maternal low protein diet in rat pregnancy programmes metabolic syndrome-like phenotype in 18 month old offspring. Proc Nutr Soc.
Ghafoorunissa, , Ibrahim, A & Natarajan, S (2005) Substituting dietary linoleic acid with [alpha]-linolenic acid improves insulin sensitivity in sucrose fed rats. Biochim Biophys Acta Mol Cell Biol Lipids 1733, 6775.
Iritani, N, Hosomi, H, Fukuda, H & Ikeda, H (1995) Polyunsaturated fatty acid regulation of lipogenic enzyme gene expression in liver of genetically obese rat. Biochim Biophys Acta 1255, 18.
Iritani, N, Komiya, M, Fukuda, H & Sugimoto, T (1998) Lipogenic enzyme gene expression is quickly suppressed in rats by a small amount of exogenous polyunsaturated fatty acids. J Nutr 128, 967972.
Katsurada, A, Iritani, N, Fukuda, H, Matsumura, Y, Nishimoto, N, Noguchi, T & Tanaka, T (1990) Effects of nutrients and hormones on transcriptional and post-transcriptional regulation of fatty acid synthase in rat liver. Eur J Biochem 190, 427433.
Korotkova, M, Gabrielsson, BG, Holmang, A, Larsson, BM, Hanson, LA & Strandvik, B (2005) Gender-related long-term effects in adult rats by perinatal dietary ratio of n-6/n-3 fatty acids. Am J Physiol Regul Integr Comp Physiol 288, R575R579.
Korotkova, M, Gabrielsson, B, Lonn, M, Hanson, LA & Strandvik, B (2002) Leptin levels in rat offspring are modified by the ratio of linoleic to {alpha}-linolenic acid in the maternal diet. J Lipid Res 43, 17431749.
Korotkova, M, Telemo, E, Yamashiro, Y, Hanson, LA & Strandvik, B (2004) The ratio of n-6 to n-3 fatty acids in maternal diet influences the induction of neonatal immunological tolerance to ovalbumin. Clin Exp Immunol 137, 237244.
Lane, RH, Kelley, DE, Gruetzmacher, EM & Devaskar, SU (2001) Uteroplacental insufficiency alters hepatic fatty acid-metabolizing enzymes in juvenile and adult rats. Am J Physiol Regul Integr Comp Physiol 280, R183R190.
Langley-Evans, SC, Clamp, AG, Grimble, RF & Jackson, AA (1996) Influence of dietary fats upon systolic blood pressure in the rat. Int J Food Sci Nutr 47, 417425.
Lien, EL, Boyle, FG, Yuhas, RJ & Kuhlman, CF (1994) Effect of maternal dietary arachidonic or linoleic acid on rat pup fatty acid profiles. Lipids 29, 5359.
Lillycrop, KA, Phillips, ES, Jackson, AA, Hanson, MA & Burdge, GC (2005) Dietary protein restriction of pregnant rats induces and folic acid supplementation prevents epigenetic modification of hepatic gene expression in the offspring. J Nutr 135, 13821386.
McMullen, S & Langley-Evans, SC (2005) Maternal low-protein diet in rat pregnancy programs blood pressure through sex-specific mechanisms. Am J Physiol Regul Integr Comp Physiol 288, R85R90.
Maloney, CA, Gosby, AK, Phuyal, JL, Denyer, GS, Bryson, JM & Caterson, ID (2003) Site-specific changes in the expression of fat-partitioning genes in weanling rats exposed to a low-protein diet in utero. Obes Res 11, 461468.
Maloney, CA, Lilley, C, Cruickshank, M, McKinnon, C, Hay, SM & Rees, WD (2005) The expression of growth-arrest genes in the liver and kidney of the protein-restricted rat fetus. Br J Nutr 94, 1218.
Marin, MC, De Tomas, ME, Serres, C & Mercuri, O (1995) Protein-energy malnutrition during gestation and lactation in rats affects growth rate, brain development and essential fatty acid metabolism. J Nutr 125, 10171024.
Nettleton, JA & Katz, R (2005) n-3 long-chain polyunsaturated fatty acids in type 2 diabetes: a review. J Am Diet Assoc 105, 428440.
Pawlak, DB, Kushner, JA & Ludwig, DS (2004) Effects of dietary glycaemic index on adiposity, glucose homoeostasis, and plasma lipids in animals. Lancet 364, 778785.
Pine, AP, Jessop, NS & Oldham, JD (1994) Maternal protein reserves and their influence on lactational performance in rats. Br J Nutr 71, 1327.
Plagemann, A (2005) Perinatal programming and functional teratogenesis: impact on body weight regulation and obesity. Physiol Behav 86, 661668.
Ramanadham, S, Song, H, Bao, S, Hsu, FF, Zhang, S, Ma, Z, Jin, C & Turk, J (2004) Islet complex lipids: involvement in the actions of group VIA calcium-independent phospholipase A(2) in beta-cells. Diabetes 53, Suppl. 1, S179S185.
Rees, WD, Hay, SM, Buchan, V, Antipatis, C & Palmer, RM (1999) The effects of maternal protein restriction on the growth of the rat fetus and its amino acid supply. Br J Nutr 81, 243250.
Rees, WD, Hay, SM & Cruickshank, M (2006 a) An imbalance in the methionine content of the maternal diet reduces postnatal growth in the rat. Metabolism 55, 763770.
Rees, WD, Hay, SM, Cruickshank, M, Reusens, B, Remacle, C, Antipatis, C & Grant, G (2006 b) Maternal protein intake in the pregnant rat programs the insulin axis and body composition in the offspring. Metabolism 55, 642649.
Siemelink, M, Verhoef, A, Dormans, JA, Span, PN & Piersma, AH (2002) Dietary fatty acid composition during pregnancy and lactation in the rat programs growth and glucose metabolism in the offspring. Diabetologia 45, 13971403.
Simopoulos, AP (1999) Essential fatty acids in health and chronic disease. Am J Clin Nutr 70, 560S569S.
Storlien, LH, Kriketos, AD, Calvert, GD, Baur, LA & Jenkins, AB (1997) Fatty acids, triglycerides and syndromes of insulin resistance. Prostaglandins Leukot Essent Fatty Acids 57, 379385.
Uauy, R, Mena, P & Rojas, C (2000) Essential fatty acids in early life: structural and functional role. Proc Nutr Soc 59, 315.
Zambrano, E, Bautista, CJ, Deas, M, Martinez-Samayoa, PM, Gonzalez-Zamorano, M, Ledesma, H, Morales, J, Larrea, F & Nathanielsz, PW (2006) A low maternal protein diet during pregnancy and lactation has sex- and window of exposure-specific effects on offspring growth and food intake, glucose metabolism and serum leptin in the rat. J Physiol 571, 221230.
Zhang, J, Wang, C, Terroni, PL, Cagampang, FR, Hanson, M & Byrne, CD (2005) High-unsaturated-fat, high-protein, and low-carbohydrate diet during pregnancy and lactation modulates hepatic lipid metabolism in female adult offspring. Am J Physiol Regul Integr Comp Physiol 288, R112R118.

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