Skip to main content Accessibility help
×
Home

The influence of vitamin A status on the response of chickens to aflatoxin B1 and changes in liver lipid metabolism associated with aflatoxicosis

  • W. L. Bryden (a1), R. B. Cumming (a1) and D. Balnave (a1)

Abstract

1 A series of experiments were conducted to investigate the effects of dietary retinol status on chickens ingesting aflatoxin B1. The effects of dietary supplementation with biotin and α-tocopherol were also examined.

2. Aflatoxin B1 levels greater than I mg/kg diet had a detrimental effect on ‘liveability’, body-weight gain, food intake and food conversion efficiency. When fed for more than 2 weeks aflatoxin increased relative liver weight and liver lipid concentration. These effects were less pronounced with avitaminotic A chickens.

3. A synergistic effect on hydropericardium development was observed between aflatoxin B, and retinol. This effect was not observed when the dietary level of α-tocopherol was increased tenfold.

4. The specific activities of certain hepatic lipogenic and amino acid-metabolizing enzymes were influenced by aflatoxin ingestion. A reduction in lipogenic enzyme activity was observed before a reduction in the activities of amino acid-metabolizing enzymes.

5. Liver fatty acid composition was significantly influenced by aflatoxin B1. The extent of these changes was reduced by the inclusion of additional dietary biotin.

Copyright

References

Hide All
Allcroft, R. (1969). In Aflatoxin: Scientific Background, Control and Implications. [Goldblatt, L. A., editor]. London: Academic Press.
Allcroft, R. & Lewis, G. (1963). Vet. Rec. 75, 487.
Balnave, D. (1966). Proc. 13th Wld's Poult. Congr.Kiev p. 213.
Balnave, D., Cumming, R. B. & Sutherland, T. M. (1977). Br. J. Nutr. 38, 319.
Becking, G. C. (1973). Can. J. Physiol. Pharmac. 51, 6.
Bird, H. R. & Culton, T. G. (1940). Proc. Soc. exp. Biol. Med. 44, 543.
Bryden, W. L., Rajion, M. A., Lloyd, A. B. & Cumming, R. B. (1975). Aust. vet. J. 51, 491.
Campbell, T. C. & Hayes, J. R. (1976). Toxic. appl. Pharmac. 35, 199.
Carnaghan, R. B. A., Lewis, G., Patterson, D. S. P. & Allcroft, R. (1966). Path. vet. 3, 601.
Clifford, J. I. & Rees, K. R. (1967). Biochem. J. 102, 65.
Combs, G. F. Jr (1976). J. Nutr. 106, 967.
Donaldson, W. E., Tung, H. T. & Hamilton, P. B. (1972). Comp. Biochem. Physiol. 41B, 843.
Ferrando, R., Trauhaut, R., Graillot, C., Gak, J. C. & Fourlon, C. (1974). C. r. hebd. Séanc. Acad. Sci., Paris. 279D, 999,
Ferrando, R., Trauhaut, R., Graillot, C., Gak, J. C. & Fourlon, C. cited In Nutr. Abstr. Rev. (1976) 48, 108.
Folch, J., Lees, N. & Sloane Stanley, C. H. (1957). J. biol. Chem. 226, 497.
Giles, K. W. & Myers, A. (1965). Nature, Lond. 206, 93.
Gumbmann, M. R. & Williams, S. N. (1969). Toxic. appl. Pharmac. 15, 393.
Hamilton, P. B. (1977). Fedn Proc. Fedn Am. Socs exp. Biol. 36, 1899.
Hamilton, P. B., Tung, H. T., Harris, J. R., Gainer, J. H. & Donaldson, W. E. (1972). Poult. Sci. 51, 165.
Hamilton, P. B., Tung, H. T., Wyatt, R. D. & Donaldson, W. E. (1974). Poult. Sci. 53, 871.
Harding, J. D. J., Done, J. T., Lewis, G. & Allcroft, R. (1963). Res. vet. Sci. 4, 217.
Hatcher, D. W. & Goldstein, G. (1969). Analyt. Biochem. 31, 42.
Hood, R. L. (1975). J. Sci. Fd Agric. 26, 1847.
Knake, R. P., Rao, C. S. & Deyoe, C. W. (1973). Poult. Sci. 52, 2050.
Kriz, H. (1970). Acta vet., Brno 39, 131.
Kyrein, H. J. (1974). Z. Lebensm. Unters-Forsch. 154, 285.
Layne, E. (1957). In Methods in Enzymology, Vol. 3, p. 450 [Colowick, S. P. & Kapalan, N. O., editors]. New York: Academic Press.
McCuaig, L. W., Carlson, H. C. & Motzok, I. (1972). Poult. Sci. 51, 1206.
McCuaig, L. W. & Motzok, I. (1970). Poult. Sci. 49, 1050.
Mallia, A. K., Smith, J. E. & Goodman, D. S. (1975). J. Lipid Res. 16, 180.
Marchetti, M., Ottani, V. & Puddu, P. (1966). Archs Biochem. Biophys. 115, 84.
Marchetti, M. & Puddu, P. (1964). Archs Biochem. Biophys. 108, 468.
Munro, H. N. & Fleck, A. (1966). Analyst, Lond. 91, 78.
Newberne, P. M. (1973). J. Am. vet. Med. Ass. 163, 1262.
Newberne, P. M. & Butler, W. H. (1969). Cancer Res. 29, 236.
Newberne, P. M. & Rogers, A. E. (1973). J. natn Cancer Inst. 50, 439.
Patterson, D. S. P. (1973). Fd Cosmet. Toxic. 11, 287.
Payne, C. G., Gilchrist, P., Pearson, J. A. & Hemsley, L. A. (1974). Br. Poult. Sci. 15, 489.
Pearce, J. & Balnave, D. (1975). Biochem. Pharmac. 24, 1843.
Pearce, J. & Balnave, D. (1976). Horm. Metab. Res. 8, 181.
Pearson, J. A., Fogerty, A. C., Johnson, A. R. & Shenstone, F. S. (1972). Lipids 7, 437.
Pons, W. A., Cucullu, A. F. & Franz, A. O. (1972). J. Ass. Off. Analyt. Chem. 55, 768.
Pudelkiewicz, W.J., Webster, L. & Matterson, L. D. (1964). J. Nutr. 84, 113.
Pudelkiewicz, W. J., Webster, L., Olson, G. & Matterson, L. D. (1964). Poult. Sci. 43, 1157.
Reddy, G.R., Tilak, T. B. G. & Krishnamurthi, D. (1973). Fd Cosmet. Toxic. 11, 467.
Scott, M. L., Nesheim, M. C. & Young, R. J. (1969). Nutrition of the Chicken. New York: M. L. Scott & Associates.
Shank, R. C. & Wogan, G. N. (1966). Toxic. appl. Pharmac. 9, 468.
Singh, V. N., Singh, M. & Venkitasubramanian, T. A. (1969). J. Lipid Res. 10, 395.
Smith, J. W. & Hamilton, P. B. (1970). Poult. Sci. 49, 207.
Snedecor, G. W. & Cochran, W. G. (1967). Statistical Methods, 6th ed.Ames, lowa: Iowa State University Press.
Squibb, R. L. (1963). Poult Sci. 42, 1332.
Todd, G.C., Shalkop, W. T., Dooley, K. L. & Wiseman, H. G. (1968). Am. J. vet. Res. 29, 1855.
Tung, H. T., Donaldson, W. E. & Hamilton, P. B. (1972). Toxic. appl. Pharmac. 22, 97.
Veen, W. A. G. (1967). Acta Physiol. Pharmac. Neerl. 14, 448.
Whitehead, C. C., Bannister, D. W., Wight, P. A. L. & Weiser, H. (1974). Proc. 15th Wid's Poult. Congr.New Orleans p. 70.
Wogan, G. N. (1966). Bact. Rev. 30, 460.
Wogan, G.N. (1975). A. Rev. Pharmac. 15, 437.
Wyatt, R. D., Thaxton, P. & Hamilton, P. B. (1975). Poult. Sci. 54, 1065.

Metrics

Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed