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Influence of the diet on the composition of faecal bile acids in rats*

Published online by Cambridge University Press:  09 March 2007

B. E. Gustafsson  and
A. Norman
B. E. Gustafsson
Affiliation:
Department of Germfree Research, Karolinska Institutet, Stockholm, Sweden
A. Norman
Affiliation:
Department of Clinical Chemistry, Danderyds Sjukhus, Danderyd, Sweden
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Abstract

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1. [24-14C]cholic acid was given orally to rats receiving three different diets, a semi-synthetic diet (D7) with and without 20% cellulose, and a commercial, pelleted diet. The labelled metabolites excreted in the faeces in the 8 days following administration of the labelled cholic acid were chromatographically separated, and tentatively identified by means of thin-layer chromatography.

2. In all three dietary groups the faecal bile acids mainly consisted of unconjugated and 7α-dehydroxylated metabolites. In rats receiving pellets or diet D7 with cellulcse, there was a higher percentage of monohydroxy-monoketo-cholanoic acids than in those receiving diet D7 alone. Dihydroxy-cholanoic acids, present in approximately the same ratio as were the 3α- and 3β-hydroxy isomers, were excreted by all the rats in the three dietary groups.

Type
Research Article
Information
British Journal of Nutrition , Volume 23 , Issue 3 , August 1969 , pp. 627 - 635
Copyright
Copyright © The Nutrition Society 1969

References

Bollman, J. L., Cain, J. C. & Grindlay, J. H. (1948). J. Lab. clin. Med. 33, 1349.Google Scholar
Cronholm, T. & Sjövall, J. (1967). Eur. J. Biochem. 2, 375.CrossRefGoogle Scholar
Danielsson, H. (1963). Adv. Lipid Res. 1, 335.CrossRefGoogle Scholar
Danielsson, H., Eneroth, P., Hellström, K., Lindstedt, S. & Sjövall, J. (1963). J. biol. Chem. 238, 2299.CrossRefGoogle Scholar
Dawson, A. M. (1967). Gut 8, 1.CrossRefGoogle Scholar
Dietschy, J. M., Salomon, H. S. & Siperstein, M. D. (1966). J. clin. Invest. 45, 832.CrossRefGoogle Scholar
Draser, B. S., Hill, M. J. & Shiner, M. (1966). Lancet i, 1237.CrossRefGoogle Scholar
Eneroth, P. (1963). J. Lipid Res. 4, 11.CrossRefGoogle Scholar
Eneroth, P., Gordon, B., Ryhage, R. & Sjövall, J. (1966). J. Lipid Res. 7, 511.CrossRefGoogle Scholar
Fitzgerald, R. J., Gustafsson, B. E. & McDaniel, E. G. (1964). J. Nutr. 84, 155.CrossRefGoogle Scholar
Gall, S. L., Fenton, P. F. & Cowgill, G. R. (1948). J. Nutr. 35, 13.CrossRefGoogle Scholar
Gustafsson, B. E., Midtvedt, T. & Norman, A. (1966). J. exp. Med. 123, 413.CrossRefGoogle Scholar
Gustafsson, B. E. & Norman, A. (1968). Scand. J. Gastroentrol. 3, 625.Google Scholar
Gustafsson, B. E. & Norman, A. (1969). Br. J. Nutr. 23, 429.CrossRefGoogle Scholar
Midtvedt, T. & Norman, A. (1967). Acta path. microbiol. scand. 71, 629.CrossRefGoogle Scholar
Norman, A. (1964). Br. J. Nutr. 18, 173.CrossRefGoogle Scholar
Norman, A. & Sjövall, J. (1958). J. biol. Chem. 233, 872.CrossRefGoogle Scholar
Olivecrona, T. & Sjövall, J. (1959). Acta physiol. scand. 46, 284.CrossRefGoogle Scholar
Tabaqchali, S. & Booth, C. C. (1966). Lancet ii, 12.CrossRefGoogle Scholar