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Influence of ß2-adrenoceptor gene polymorphisms on diet-induced thermogenesis

Published online by Cambridge University Press:  08 March 2007

J. M. Oomen ,
P. M. C. M. Waijers ,
C. van Rossum ,
B. Hoebee ,
W. H. M. Saris  and
M. A. van Baak
J. M. Oomen*
Affiliation:
Department of Human Biology/NUTRIM, Maastricht University, Maastricht, The Netherlands
P. M. C. M. Waijers
Affiliation:
Centre for Nutrition and Health, National Institute for Public Health and the Environment, Bilthoven, The Netherlands
C. van Rossum
Affiliation:
Centre for Nutrition and Health, National Institute for Public Health and the Environment, Bilthoven, The Netherlands
B. Hoebee
Affiliation:
Laboratory of Toxicology, Pathology and Genetics, National Institute for Public Health and the Environment, Bilthoven, The Netherlands
W. H. M. Saris
Affiliation:
Department of Human Biology/NUTRIM, Maastricht University, Maastricht, The Netherlands
M. A. van Baak
Affiliation:
Department of Human Biology/NUTRIM, Maastricht University, Maastricht, The Netherlands
*
*Corresponding author: Dr J. M. Oomen, fax +31 (0)43 367 9776, email j.oomen@hb.unimaas.nl
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Abstract

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The sympathetic nervous system is involved in the control of energy metabolism and expenditure. Diet-induced thermogenesis is mediated partly by the ß-adrenergic component of this system. The aim of the present study was to investigate the role of genetic variation in the ß2-adrenoceptor in diet-induced thermogenesis. Data from twenty-four subjects (fourteen men and ten women; BMI 26·7(sem 0·8) kg/m2; age 45·2(sem1·4) years) with different polymorphisms of the ß2-adrenoceptor at codon 16 (Gly16Gly, Gly16Arg or Arg16Arg) were recruited for this study. Subjects were given a high-carbohydrate liquid meal, and the energy expenditure, respiratory exchange ratio, and plasma concentrations of NEFA, glycerol, glucose, insulin and catecholamines were measured before and over 4 h after the meal. The AUC of energy expenditure (diet-induced thermogenesis) was not significantly different between polymorphism groups, nor was the response of any of the other measured variables to the meal. In a multiple regression model, the only variable that explained a significant proportion (32 %) of the variation in diet-induced thermogenesis was the increase in plasma adrenaline in response to the meal (P<0·05). The ß2-adrenoceptor codon16 polymorphisms did not contribute significantly. In conclusion, an independent contribution of the codon 16 polymorphism of the ß2-adrenoceptor gene to the variation in thermogenic response to a high-carbohydrate meal could not be demonstrated. The interindividual variation in thermogenic response to the meal was correlated with variations in the plasma adrenaline response to the meal.

Keywords

ß2-Adrenoceptor polymorphismsDiet-induced thermogenesisCatecholamines
Type
Research Article
Information
British Journal of Nutrition , Volume 94 , Issue 5 , November 2005 , pp. 647 - 654
Copyright
Copyright © The Nutrition Society 2005

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