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Influence of ß2-adrenoceptor gene polymorphisms on diet-induced thermogenesis

  • J. M. Oomen (a1), P. M. C. M. Waijers (a2), C. van Rossum (a2), B. Hoebee (a3), W. H. M. Saris (a1) and M. A. van Baak (a1)...

Abstract

The sympathetic nervous system is involved in the control of energy metabolism and expenditure. Diet-induced thermogenesis is mediated partly by the ß-adrenergic component of this system. The aim of the present study was to investigate the role of genetic variation in the ß2-adrenoceptor in diet-induced thermogenesis. Data from twenty-four subjects (fourteen men and ten women; BMI 26·7(sem 0·8) kg/m2; age 45·2(sem1·4) years) with different polymorphisms of the ß2-adrenoceptor at codon 16 (Gly16Gly, Gly16Arg or Arg16Arg) were recruited for this study. Subjects were given a high-carbohydrate liquid meal, and the energy expenditure, respiratory exchange ratio, and plasma concentrations of NEFA, glycerol, glucose, insulin and catecholamines were measured before and over 4 h after the meal. The AUC of energy expenditure (diet-induced thermogenesis) was not significantly different between polymorphism groups, nor was the response of any of the other measured variables to the meal. In a multiple regression model, the only variable that explained a significant proportion (32 %) of the variation in diet-induced thermogenesis was the increase in plasma adrenaline in response to the meal (P<0·05). The ß2-adrenoceptor codon16 polymorphisms did not contribute significantly. In conclusion, an independent contribution of the codon 16 polymorphism of the ß2-adrenoceptor gene to the variation in thermogenic response to a high-carbohydrate meal could not be demonstrated. The interindividual variation in thermogenic response to the meal was correlated with variations in the plasma adrenaline response to the meal.

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Corresponding author

*Corresponding author: Dr J. M. Oomen, fax +31 (0)43 367 9776, email j.oomen@hb.unimaas.nl

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Keywords

Influence of ß2-adrenoceptor gene polymorphisms on diet-induced thermogenesis

  • J. M. Oomen (a1), P. M. C. M. Waijers (a2), C. van Rossum (a2), B. Hoebee (a3), W. H. M. Saris (a1) and M. A. van Baak (a1)...

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