Skip to main content Accessibility help
×
Home

Influence of fructose feeding on individual enzymic reactions in the formation and metabolism of bile acids in rat liver homogenates

  • M. Carrella (a1), I. Björkhem (a1), K. Einarsson (a1) and K. Hellström (a1)

Extract

1. Rats were maintained for 10 d on a semi-synthetic diet containing 700 g glucose or 700 g fructose/kg. Individual enzymie reactions in bile acid synthesis and metabolism were studied by measuring the 7α-hydroxylation of [4-14C]cholesterol, the 12α-hydroxylation of 7α-[6β-3H]hydroxy-4-cholesten-3-one, the 26-hydroxylation of 5β-[7β-3H]cholestane-3α,7α-diol and the 6β-hydroxylation of [3H]lithocholic acid in liver homogenates.

2. The serum cholesterol level was approximately the same in both groups of animals, but the serum triglyceride level was almost twice as high in the fructose-fed rats compared to the glucose-fed rats.

3. The 6β-hydroxylation of [3H]lithocholic acid was increased by about 20% in the fructose-fed rats compared to the glucose-fed animals. The activities of the other enzymic reactions studied did not differ significantly between the two groups of animals. The findings are discussed in relation to previous knowledge concerning mechanisms regulating triglyceride, pre-β-lipoprotein and bile acid synthesis.

    • Send article to Kindle

      To send this article to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle. Find out more about sending to your Kindle.

      Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

      Find out more about the Kindle Personal Document Service.

      Influence of fructose feeding on individual enzymic reactions in the formation and metabolism of bile acids in rat liver homogenates
      Available formats
      ×

      Send article to Dropbox

      To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Dropbox.

      Influence of fructose feeding on individual enzymic reactions in the formation and metabolism of bile acids in rat liver homogenates
      Available formats
      ×

      Send article to Google Drive

      To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Google Drive.

      Influence of fructose feeding on individual enzymic reactions in the formation and metabolism of bile acids in rat liver homogenates
      Available formats
      ×

Copyright

References

Hide All
Adams, P. W., Kissebah, A. H., Harrigan, P., Stokes, T. & Wynn, V. (1974). Eur. J. clin. Invest. 4, 149.
Anderson, J. T., Grande, F., Matsumoto, Y. & Keys, A. (1963). J. Nutr. 79, 349.
Bergström, S. & Gloor, U. (1955). Acta ehem. scand. 9, 34.
Björkhem, I. (1969). Eur. J. Biochem. 8, 337.
Björkhem, I. & Danielsson, H. (1974). Mol. Cell. Biochem. 4, 79.
Björkhem, I. & Einarsson, K. (1970). Eur. J. Biochem. 13, 174.
Björkhem, I. & Gustafsson, J. (1973). Eur. J. Biochem. 36, 201.
Cohen, R. I., Raicht, R. F., Nicolau, G. & Mosbach, E. H. (1975). Lipids 10, 168.
Danielsson, H. (1973). In The Bile Acids, vol. 2, p. 1 [Nair, P. P. and Kritchevsky, D., editors]. New York: Plenum Press.
Danielsson, H. & Einarsson, K. (1966). J. biol. Chem. 241, 1449.
Danielsson, H., Einarsson, K. & Johansson, G. (1967). Eur. J. Biochem. 2, 44.
Eaton, R. P. & Kipnis, D. M. (1969). Am. J. Physiol. 217, 1160.
Einarsson, K. & Gustafsson, J.-A. (1974). Biochem. Pharmac. 23, 9.
Einarsson, K., Hellström, K. & Kallner, M. (1974). J. clin. Invest. 54, 1301.
Einarsson, K. & Johansson, G. (1969). FEBS Lett. 4, 177.
Frederickson, D. S., Levy, R. J. & Lees, R. S. (1967). New Engl. J. Med. 276, 34, 94, 148, 215, 273.
Hanel, H. K. & Dam, H. (1955). Acta chem. scand. 9, 677.
Kaufmann, N. A. & Kapitulnik, J. (1973). Acta med. scand. Suppl. 542, 229.
Laurell, S. (1966). Scand. J. clin. Lab. Invest. 18, 668.
Lowry, O. H., Rosebrough, N. J., Farr, A. L. & Randall, R. J. (1951). J. biol. Chem. 193, 265.
Macdonald, S. & Braithwaite, D. M. (1964). Clin. Sci. 27, 23.
Nestel, P. J. (1966). Clin. Sci. 31, 31.
Nikkilä, E. A. & Kekki, M. (1972). Eur. J. clin. Invest. 2, 231.
Nikkilä, E. A. & Ojala, K. (1965). Life Sci. 4, 937.
Quarfordt, S. H., Frank, A., Shames, D. M., Berman, M. & Steinberg, D. (1970). J. clin. Invest. 49, 2281.
Reaven, G. M., Hill, D. B., Gross, R. C. & Farquhar, J. W. (1965). J. clin. Invest. 44, 1826.
Schonfeld, G. & Pfleger, B. (1971). J. Lipid Res. 12, 614.
Waddell, M. & Falion, H. J. (1973). J. clin. Invest. 52, 2725.
Wu, C.-H. & Shreeve, W. W. (1975). Metabolism 24, 755.

Influence of fructose feeding on individual enzymic reactions in the formation and metabolism of bile acids in rat liver homogenates

  • M. Carrella (a1), I. Björkhem (a1), K. Einarsson (a1) and K. Hellström (a1)

Metrics

Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed