Hostname: page-component-848d4c4894-hfldf Total loading time: 0 Render date: 2024-05-15T07:04:28.862Z Has data issue: false hasContentIssue false
  • English
  • Français

Increased thirst and hunger in adult rats undernourished as infants: an alternative explanation

Published online by Cambridge University Press:  13 December 2007

J. L. Smart  and
J. Dobbing
J. L. Smart
Affiliation:
Department of Child Health, The Medical School, University of Manchester, Oxford Road, Manchester M13 9PT
J. Dobbing
Affiliation:
Department of Child Health, The Medical School, University of Manchester, Oxford Road, Manchester M13 9PT
Rights & Permissions [Opens in a new window]

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

1. Rats were undernourished in early life by feeding their mothers a restricted quantity of a good-quality diet throughout lactation. Their undernutrition continued postweaning from 25 to 42 d of age, after which they were fed ad lib. Control rats were well nourished at all times.

2. Behavioural assessment of thirst was carried out on adult males. These were deprived of water for 23 h/d throughout the period of testing. Compared to control rats, previously-undernourished (PU) rats pressed a lever at a higher rate in a Skinner box to gain a water reward, drank more frequently during their first 5 min in an unfamiliar cage, and tended to run more quickly down an alleyway for water. PU rats also drank more (/kg body-weighta0.75) of a quinine solution (1 g/l) when this was available to them ad lib. as their only source of fluid.

3. A second group of rats was growth-retarded during gestation and the suckling and early postweaning periods. The rats had free access to food from 42 d of age. In adulthood their ad lib. food and water consumption was measured. PU males ate and drank more (/kg body-weight0.75) than control males.

4. These results indicate that adult rats which have been undernourished in early life display increased thirst. An attempt is made to explain this finding, together with their previously-demonstrated enhanced hunger drive, purely in terms of gross anatomical and physiological differences.

Type
Papers of direct relevance to Clinical and Human Nutrition
Information
British Journal of Nutrition , Volume 37 , Issue 3 , May 1977 , pp. 421 - 430
Copyright
Copyright © The Nutrition Society 1977

References

REFERENCES

Baird, A., Widdowson, E. M. & Cowley, J. J. (1971). Br. J. Nutr. 25, 391.CrossRefGoogle Scholar
Barnes, R. H. (1967). Fedn Proc. Fedn Am. Socs Exp. Biol. 26, 144.Google Scholar
Barnes, R. H., Kwong, E., Morrissey, L., Vilhjalmsdottir, L. & Levitsky, D. A. (1973). J. Nutr. 103, 273.CrossRefGoogle Scholar
Barnes, R. H., Neely, C. S., Kwong, E., Labadan, B. A. & Fraňková, S. (1968). J. Nutr. 96, 467.CrossRefGoogle Scholar
Brody, S. (1945). Bioenergetics and Growth. New York: Hafner.Google Scholar
Bronfenbrenner, U. (1968). In Early Experience and Behavior, p. 629 [Newton, G. and Levine, S. editors]. Springfield, Illinois: Thomas.Google Scholar
D'Amato, M. R. (1960). Psychol. Rep. 7, 91.CrossRefGoogle Scholar
Davenport, D. G. & Goulet, L. R. (1964). J. comp. physiol. Psychol. 57, 237.CrossRefGoogle Scholar
Ferster, C. B. & Skinner, B. F. (1957). Schedules of Reinforcement. New York: Appleton-Century-Crofts.CrossRefGoogle ScholarPubMed
Levitsky, D. A. & Barnes, R. H. (1970). Nature, Lond. 225, 468.CrossRefGoogle Scholar
Lynch, A., Smart, J. L. & Dobbing, J. (1975). Brain Res. 83, 249.CrossRefGoogle Scholar
Munn, N. L. (1950). Handbook of Psychological Research on the Rat. Boston, Massachusetts: Houghton Mifflin.Google Scholar
Simonson, M. & Chow, B. F. (1970). J. Nutr. 100, 685.CrossRefGoogle Scholar
Smart, J. L., Adlard, B. P. F. & Dobbing, J. (1974). Biol. Neonate 25, 135.CrossRefGoogle Scholar
Smart, J. L., Dobbing, J., Adlard, B. P. F., Lynch, A. & Sands, J. (1973). J. Nutr. 103, 1327.CrossRefGoogle Scholar
Smart, J. L., Whatson, T. S. & Dobbing, J. (1975). Br. J. Nutr. 34, 511.CrossRefGoogle Scholar
Widdowson, E. M. & McCance, R. A. (1960). Proc. R. Soc. B 152, 188.Google Scholar