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Hypolipidaemic effect of maize starch with different amylose content in ovariectomized rats depends on intake amount of resistant starch

  • Xiong Liu (a1) (a2), Hiroshi Ogawa (a3), Taro Kishida (a1) and Kiyoshi Ebihara (a1)

Abstract

The effect of amylose content on digestibility of starch in the small intestine and on the concentration of plasma lipid were studied in ileorectostomized rats and in ovariectomized rats, respectively. Seven kinds of starch with different amylose content (0, 27, 54, 62, 76, 79, 86 %) were used as test starch, which contained 0·4, 5·6, 37·1, 40·2, 45·6, 36·9 and 36·1 % resistant starch (RS), respectively. Rats were fed one of test diets containing 30 % test starch with different amylose content for 14 d in ileorectostomized and for 21 d in ovariectomized rats. Food intake was not significantly different among the groups. In ileorectostomized rats, the small intestinal starch digestibility decreased with increasing intakes of amylose and RS. In ovariectomized rats, body weight gain was lower on the higher amylose maize starch diets. The concentrations of plasma TAG and cholesterol decreased with increasing intake of RS. The concentrations of liver total lipids and TAG decreased with increasing intake of RS, but that of liver cholesterol did not. There was significant positive correlation between the level of sterol regulatory element-binding protein-1c mRNA and concentration of liver TAG. Total SCFA amount in the caecum increased logarithmically with increasing dry weight of caecal contents. The amount of bile acids in the small intestinal content and the excretions of bile acids and neutral steroids in faeces increased with increasing RS intake. These results show that starch rich in RS is more effective in preventing ovarian hormone deficiency-induced hyperlipidaemia.

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Corresponding author

*Corresponding author: Dr Kiyoshi Ebihara, fax +81 89 946 9847, email ebihara@agr.ehime-u.ac.jp

References

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1Gevers Leuven, JA (1994) Sex steroids and lipoprotein metabolism. Pharmacol Ther 64, 99126.
2Shono, N, Kumagai, S & Sasaki, H (1996) Obesity, glucose and lipid metabolism, and steroid hormones (in Japanese). J Health Sci 18, 2144.
3Sullivan, TR Jr, Karas, RH, Aronovitz, M, Faller, GT, Ziar, JP, Smith, JJ, O'Donnell, TF Jr & Mendelsohn, ME (1995) Estrogen inhibits the response-to-injury in a mouse carotid artery model. J Clin Invest 96, 24822488.
4Chen, SJ, Li, H, Durand, J, Oparil, S & Chen, YE (1996) Estrogen reduces myointimal proliferation after balloon injury of rat carotid artery. Circulation 93, 577584.
5de Deckere, EA, Kloots, WJ & van Amelsvoort, JM (1993) Resistant starch decreases serum total cholesterol and triacylglycerol concentrations in rats. J Nutr 123, 21422151.
6de Deckere, EA, Kloots, WJ & van Amelsvoort, JM (1995) Both raw and retrograded starch decrease serum triacylglycerol concentration and fat accretion in the rat. Br J Nutr 73, 287298.
7Ranhotra, GS, Gelroth, JA & Leinen, SD (1997) Hypolipidemic effect of resistant starch in hamsters is not dose dependent. Nutr Res 17, 317323.
8Kishida, T, Nogami, H, Himeno, S & Ebihara, K (2001) Heat moisture treatment of high amylose corn starch increases its resistant starch content but not its physiologic effects in rats. J Nutr 131, 27162721.
9Morita, T, Kasaoka, S, Ohhashi, A, Ikai, M, Numasaki, Y & Kiriyama, S (1998) Resistant proteins alter caecal short-chain fatty acid profiles in rats fed high amylose cornstarch. J Nutr 128, 11561164.
10Livesey, G (1995) The impact of complex carbohydrates on energy balance. Eur J Clin Nutr 49, Suppl. 3, S89S96.
11Folch, J, Lees, M & Sloane Stanley, GH (1957) A simple method for the isolation and purification of total lipides from animal tissue. J Biol Chem 226, 497509.
12Carr, TP, Andresen, CJ & Rudel, LL (1993) Enzymatic determination of triglyceride, free cholesterol, and total cholesterol in tissue lipid extracts. Clin Biochem 26, 3942.
13Eneroth, P, Hellstrom, K & Sjovall, J (1968) A method for quantitative determination of bile acids in human feces. Acta Chem Scan 22, 17291744.
14Sheltaway, MJ & Losowsky, MS (1975) Determination of fecal bile acids by an enzymic method. Clin Chem Acta 64, 127132.
15Kishida, T, Ishikawa, H, Tsukaoka, M, Ohga, H, Ogawa, H & Ebihara, K (2003) Increase of bile acids synthesis and excretion caused by taurine administration prevents the ovariectomy-induced increase in cholesterol concentrations in the serum low-density lipoprotein fraction of Wistar rats. J Nutr Biochem 14, 716.
16Liu, X, Sawauchi, H, Ogawa, H, Kishida, T & Ebihara, K (2006) Retrograded tapioca starch prevents ovarian hormone deficiency-induced hypercholesterolemia. J Nutr Sci Vitaminol 52, 134141.
17Ebihara, K, Shiraishi, R & Okuma, K (1998) Hydroxypropyl-modified potato starch increases fecal bile acid excretion in rats. J Nutr 128, 848854.
18Chomczynski, P & Sacchi, N (1987) Single-step method of RNA isolation by acid guanidinium thiocyanate–phenol–chloroform extraction. Anal Biochem 162, 156159.
19Brown, IL, McNaught, KJ, Andrews, D & Morita, T (2001) Resistant starch: plant breeding, application development and commercial use. In Advanced Dietary Fibre Technology, pp. 401412 [McCleary, BV and Prosky, L, editors]. Oxford: Blackwell Science.
20Cheetham, NWH & Tao, L (1998) Variation in crystalline type with amylose content in maize starch granules: an X-ray powder diffraction study. Carbohydr Polym 36, 277284.
21Chen, P, Yu, L, Chen, L & Li, X (2000) Morphology and microstructure of maize starches with different amylose/amylopectin content. Starch/Starke 58, 611615.
22Snow, P & O'Dea, K (1981) Factors affecting the rate of hydrolysis of starch in food. Am J Clin Nutr 34, 27212727.
23Parker, R & Ring, SG (2001) Aspects of physical chemistry of starch. J Cereal Sci 34, 117.
24Morita, T, Ito, Y, Brown, IL, Ando, R & Kiriyama, S (2007) In vitro and in vivo digestibility of native maize starch granules varying in amylose contents. J AOAC Int 90, 16281634.
25Riley, CK, Wheatley, AO, Hassan, I, Ahmad, MH, Morrison, EStY & Asemota, HN (2004) In vitro digestibility of raw starches extracted from five yam (Dioscrea spp.) species grown in Jamaica. Starch/Starke 56, 6973.
26Lape, IM & Treche, S (1994) Nutritional quality of yam (Dioscorea dumentorum and Dioscorea rotundata) flours for growing rats. J Sci Food Agric 66, 447455.
27Hoover, R (2001) Composition, molecular structure, and physicochemical properties of tuber and root starches: a review. Carbohydr Polym 45, 253267.
28El-Harith, EH, Dickerson, JW & Walker, R (1976) Nutritive value of various starches for the albino rat. J Sci Food Agric 27, 521526.
29Truswell, AS (1978) Energy balance and serum lipids. Naringsforskning 22, 6571.
30Chen, W-J, Anderson, J & Jennings, D (1984) Propionate may mediate the hypocholesterolaemic effects of certain soluble fibers in cholesterol-fed rats. Proc Soc Exp Biol Med 175, 215218.
31Abadie, C, Hug, M, Kubli, C & Gains, N (1994) Effect of cyclodextrins and undigested starch on the loss of chenodeoxycholate in the faeces. Biochem J 299, 725730.
32Illman, RJ, Topping, DL, McIntosh, GH, Trimble, RP, Storer, GB, Taylor, MN & Cheng, BQ (1988) Hypocholesterolaemic effects of dietary propionate: studies in whole animals and perfused rat liver. Ann Nutr Metab 32, 95107.
33Beaulieu, KE & McBurney, MI (1992) Changes in pig serum lipids, nutrient digestibility and sterol excretion during cecal infusion of propionate. J Nutr 122, 241245.
34Sacquet, E, Leprince, C & Riottot, M (1983) Effect of amylomaize starch on cholesterol and bile acid metabolisms in germfree (axenic) and conventional (holoxenic) rats. Reprod Nutr Dev 23, 783792.
35Goda, T, Urakawa, T, Watanabe, M & Takase, S (1994) Effect of high-amylose starch on carbohydrate digestive capability and lipogenesis in epididymal adipose tissue and liver of rats. J Nutr Biochem 5, 256260.
36Morand, C, Levrat, MA, Besson, C, Demigne, C & Remesy, C (1994) Effects of a diet rich in resistant starch on hepatic lipid metabolism in the rat. J Nutr Biochem 5, 138144.
37Kasaoka, S, Morita, T, Ikai, M, Ohhashi, A & Kiriyama, S (1998) High-amylose cornstarch prevents increased serumlipids and body fat accretion in rats (in Japanese). J Jpn Soc Nutr Food Sci 51, 345353.
38Lopez, HW, Levrat-Verny, MA, Coudray, C, Besson, C, Krespine, V, Messager, A, Demigne, C & Remesy, C (2001) Class 2 resistant starches lower plasma and liver lipids and improve mineral retention in rats. J Nutr 131, 12831289.
39Byrnes, SE, Miller, JC & Denyer, GS (1995) Amylopectin starch promotes the development of insulin resistance in rats. J Nutr 125, 14301437.
40Gibbons, GF (1990) Assembly and secretion of hepatic very-low-density lipoprotein. Biochem J 268, 113.
41Arbeeny, CM, Meyers, DS, Bergquist, KE & Gregg, RE (1992) Inhibition of fatty acid synthesis decreases very low density lipoprotein secretion in the hamster. J Lipid Res 33, 843851.
42Demigne, C, Morand, C, Levrat, MA, Besson, C, Moundras, C & Remesy, C (1995) Effect of propionate on fatty acid and cholesterol synthesis and on acetate metabolism in isolated rat hepatocytes. Br J Nutr 74, 209219.
43Lin, Y, Vonk, RJ, Slooff, MJ, Kuipers, F & Smit, MJ (1995) Differences in propionate-induced inhibition of cholesterol and triacylglycerol synthesis between human and rat hepatocytes in primary culture. Br J Nutr 74, 197207.
44Delzenne, NM, Daubioul, C, Neyrinck, A, Lasa, M & Taper, HS (2002) Inulin and oligofructose modulate lipid metabolism in animals: review of biochemical events and future prospects. Br J Nutr 87, Suppl. 2, S255S259.
45Horton, JD, Goldstein, JL & Brown, MS (2002) SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver. J Clin Invest 109, 11251131.
46Chiang, JYL (1998) Regulation of bile acid synthesis. Frontiers Biosci 3, 176193.
47Taniguchi, T, Chen, J & Cooper, AD (1994) Regulation of cholesterol 7α-hydroxylase gene expression in Hep-G2 cells. J Biol Chem 269, 1007110078.
48Ellis, E, Axelson, M, Abrahamsson, A, Eggertsen, G, Thorne, A, Nowak, G, Ericzon, BG, Bjorkhem, I & Einarsson, C (2003) Feedback regulation of bile acid synthesis in primary human hepatocytes: evidence that CDCA is the strongest inhibitor. Hepatology 38, 930938.
49Davis, RA, Miyake, JH, Hui, TY & Spann, NJ (2002) Regulation of cholesterol-7alpha-hydroxylase: BAREly missing a SHP. J Lipid Res 43, 533543.
50Parks, DJ, Blanchard, SG, Bledsoe, RK, et al. (1999) Bile acids: natural ligands for an orphan nuclear receptor. Science 284, 13651368.
51Einarsson, C, Hillebrant, CG & Axelson, M (2001) Effects of treatment with deoxycholic acid and chenodeoxycholic acid on the hepatic synthesis of cholesterol and bile acids in healthy subjects. Hepatology 33, 11891193.
52Verbeek, MJ, De Deckere, EA, Tijburg, LB, Van Amelsvoort, JM & Beynen, AC (1995) Influence of dietary retrograded starch on the metabolism of neutral steroids and bile acids in rats. Br J Nutr 74, 807820.
53Macfarlane, S & Macfarlane, GT (2003) Regulation of short-chain fatty acid production. Proc Nutr Soc 52, 367373.
54Rubinstein, R, Howard, AV & Wrong, OM (1969) In vivo dialysis of faeces as a method of stool analysis. IV. The organic anion component. Clin Sci 37, 549564.
55Hoshi, S, Sakata, T, Mikuni, K, Hashimoto, H & Kimura, S (1994) Galactosylsucrose and xylosylfructoside alter digestive tract size and concentrations of cecal organic acids in rats fed diets containing cholesterol and cholic acid. J Nutr 124, 5260.
56Kasaoka, S, Morita, T, Ikai, M, Oh-hashi, A & Kiriyama, S (1999) Effect of high-amylose cornstarch on fecal excretion in rats (in Japanese). J Jpn Soc Nutr Food Sci 52, 263270.
57Macfarlane, GT & Macfarlane, S (1993) Factors affecting fermentation reactions in the large bowel. Proc Nutr Soc 52, 367373.
58Umesaki, Y, Yajima, T, Tohyama, K & Mutai, M (1979) Effect of organic acid absorption on bicarbonate transport in rat colon. Pflugers Arch 14, 4347.
59Kellogg, TF (1973) On the site of the microbiological reduction of cholesterol to coprostanol. Lipids 8, 658659.
60Eyssen, HJ, Partmentier, GG, Compernolle, FC, De Pauw, G & Piessens-Denef, M (1973) Biohydrogenation of sterol by Eubacterium ATCC 21,408-nova species. Eur J Biochem 36, 411421.
61Sadzikowski, MR, Sperry, JF & Wilkins, TD (1977) Cholesterol-reducing bacterium from human feces. Appl Environ Microbiol 34, 355362.
62Kishida, T, Nogami, H, Ogawa, H & Ebihara, K (2002) The hypocholesterolemic effect of high amylose cornstarch in rats is mediated by an enlarged bile acid pool and increased fecal bile acid excretion, not by cecal fermented products. J Nutr 132, 25192524.
63Reeves, PG, Nielsen, FH & Fahey, GC Jr (1993) AIN-93 purified diets for laboratory rodents: final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet. J Nutr 123, 19391951.

Keywords

Hypolipidaemic effect of maize starch with different amylose content in ovariectomized rats depends on intake amount of resistant starch

  • Xiong Liu (a1) (a2), Hiroshi Ogawa (a3), Taro Kishida (a1) and Kiyoshi Ebihara (a1)

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