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High-fat diets affect the expression of nuclear retinoic acid receptor in rat liver

Published online by Cambridge University Press:  09 March 2007

S. Bonilla ,
A. Redonnet ,
C. Noël-Suberville ,
V. Pallet ,
H. Garcin  and
P. Higueret
S. Bonilla
Affiliation:
Laboratoire de Nutrition-ISTAB, Université Bordeaux I, Avenue des Facultés, 33405 Talence-Cedex, France
A. Redonnet
Affiliation:
Laboratoire de Nutrition-ISTAB, Université Bordeaux I, Avenue des Facultés, 33405 Talence-Cedex, France
C. Noël-Suberville
Affiliation:
Laboratoire de Nutrition-ISTAB, Université Bordeaux I, Avenue des Facultés, 33405 Talence-Cedex, France
V. Pallet
Affiliation:
Laboratoire de Nutrition-ISTAB, Université Bordeaux I, Avenue des Facultés, 33405 Talence-Cedex, France
H. Garcin
Affiliation:
Laboratoire de Nutrition-ISTAB, Université Bordeaux I, Avenue des Facultés, 33405 Talence-Cedex, France
P. Higueret*
Affiliation:
Laboratoire de Nutrition-ISTAB, Université Bordeaux I, Avenue des Facultés, 33405 Talence-Cedex, France
*
*Corresponding author: Professor P. Higueret, fax +33 5 56 84 27 76, email p.higueret@istab.u-bordeaux.fr
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Abstract

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The purpose of this study was to differentiate between the effects of the amount and the type of dietary lipids on the expression of the retinoic acid receptor (RAR), but also the peroxisome proliferator-activated receptor (PPAR) and the receptor of the 9-cis retinoic acid (retinoid X receptor (RXR)) in rat liver. Six groups of eight rats (5-weeks old) were fed during 4 weeks on the following diets: control 50 g vegetable oil/kg, high-fat diet 250 g vegetable oil/kg. These oils were either coconut oil (rich in saturated fatty acids) or olive oil (rich in monounsaturated fatty acids) or safflower oil (rich in polyunsaturated fatty acids, mainly as n-6). The three high-fat diets induced a significant decrease of the maximal binding capacity of RAR and of the abundance of RARβ mRNA. Simultaneously, an increased expression of PPARα mRNA was observed while no significant difference on abundance of RXRα mRNA was observed. The mechanisms involved are probably multiple, but one hypothesis is that a modification of the equilibrium between the nuclear receptors, resulting from an increased expression of PPAR, induces a decreased expression of RAR in rat liver.

Keywords

Rat liverHigh-fat dietRetinoic acid receptor expression
Type
Research Article
Information
British Journal of Nutrition , Volume 83 , Issue 6 , June 2000 , pp. 665 - 671
Copyright
Copyright © The Nutrition Society 2000

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