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Hexose transport and mucosal morphology in the small intestine of the zinc-deficient rat

Published online by Cambridge University Press:  09 March 2007

Susan Southon ,
Jennifer M. Gee  and
I. T. Johnson
Susan Southon
Affiliation:
AFRC Food Research Institute, Colney Lane, Norwich NR4 7UA
Jennifer M. Gee
Affiliation:
AFRC Food Research Institute, Colney Lane, Norwich NR4 7UA
I. T. Johnson
Affiliation:
AFRC Food Research Institute, Colney Lane, Norwich NR4 7UA
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Abstract

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1. Immature male Wistar rats were given a zinc-depleted semi-synthetic diet (2 mg Zn/kg diet) for 4 weeks. Control groups received a similar diet containing 60 mg Zn/kg diet, either ad lib. or in amounts matched to the consumption of the Zn-deficient group. Rates of growth and food conversion efficiency were markedly lower in the Zn-deficient group compared to controls.

2. The phloridzin-sensitive uptake of galactose and 3-0-methyl glucose by everted jejunal rings from each group was measured over a range of concentrations. Kinetic analysis revealed that the maximum transport rate (Vmax)for the uptake of both sugars was significantly higher in the Zn-deficient group than in the control groups.

3. The villi, microdissected from samples of proximal jejunum, were significantly shorter and narrower across the base in the Zn-deficient group than those of the control groups, but were present in greater numbers per unit serosal area.

4. The present study shows that Zn deficiency leads to significant morphological changes in rat small intestine, which are accompanied by an increase in the capacity of the tissue to take up sugars across the mucosal membrane.

Type
Papers on General Nutrition
Information
British Journal of Nutrition , Volume 52 , Issue 2 , September 1984 , pp. 371 - 380
Copyright
Copyright © The Nutrition Society 1984

References

Baudon, J. J., Fontaine, J. L., Larregue, M., Feldmann, G. & Laplane, R. (1978). Archives Francaises de Pediatrie 35, 63–73.Google Scholar
Clarke, R. M. (1970). Journal of Anatomy 107, 519–529.Google Scholar
Debnam, E. S. & Levin, R. J. (1973). Journal of Physiology 231, 21p–23P.Google Scholar
Duggleby, R. G. (1981). Analytical Biochemistry 110, 9–18.CrossRefGoogle Scholar
Elmes, M. E. & Gwyn-jones, J. (1980). Journal of Pathology 130, 37–43.CrossRefGoogle Scholar
Fiszer-szafarz, B., Szafarz, D. & Alba de murilla, A. (1981). Analytical Biochemistry 110, 165–170.CrossRefGoogle Scholar
Hendricks, D. G. & Mahoney, A. W. (1972). Journal of Nutrition 102, 1079–1084.CrossRefGoogle Scholar
James, W. P. T., Ragbeer, M. M. S. & Walshe, M. M. (1969). West Indian Medical Journal 18, 17–24.Google Scholar
Kinter, W. B. & Wilson, T. H. (1965). Journal of Cell Biology 25, 19–39.Google Scholar
Koo, S. I. & Turk, D. E. (1977 a). Journal of Nutrition 107, 896–908.Google Scholar
Koo, S. I. & Turk, D. E. (1977 b). Journal of Nutrition 107, 909–919.CrossRefGoogle Scholar
Levin, R. J. (1967). British Medical Bulletin 23, 209–212.CrossRefGoogle Scholar
Levinson, R. A. & Englert, E. (1972). Experientia 28, 1039.CrossRefGoogle Scholar
Lowry, O. H., Rosebrough, N. J., Lewis Farr, A. & Randall, R. J. (1951). Journal of Biological Chemistry 193, 265–275.Google Scholar
Mills, C. F., Quarterman, J., Chesters, J. K., Williams, R. B. & Dalgano, A. C. (1969). American Journal of Clinical Nutrition 22, 1240–1249.CrossRefGoogle Scholar
Mosteller, F. & Tukey, J. W. (1977). Data analysis and Regression, pp. 353–365. Massachusetts: Addison-wesley.Google Scholar
Moynahan, E. J., Johnson, F. R. & McMinn, R. M. H. (1962). Proceedings of the royal society of medicine 55, 300–301.Google Scholar
Newey, H., Parsons, B. J. & Smyth, D. H. (1959). Journal of Physiology 148, 83–92.CrossRefGoogle Scholar
Prasad, A. S. & Oberleas, D. (1974). Journal of Laboratory and clinical Medicine 83, 634–639.Google Scholar
Quarterman, J., Mills, C. F. & Humphries, W. R. (1966). Biochemical and Biophysical Research Communications 25, 354–359.Google Scholar
Rayhanzadeh, S. & Dantzig, P. (1974). Pediatrics 54, 77–80.Google Scholar
Reeves, P. G. &Odell, B. L. (1983). British Journal of Nutrition 49, 441–452.Google Scholar
Roche, A. C., Bognel, J. C., Bognel, C. & Bemier, J. J. (1970). Digestion 3, 195–212.Google Scholar
Sandstead, H. H. & Rinaldi, R. A. (1969). Journal of Cellular Physiology 73, 81–84.Google Scholar
Walsh, J. H. (1981). In Physiology of the Gastrointestinal Tract, pp. 59–144 [Johnson, L. R., editor]. New york: Raven press.Google Scholar
Wilson, H. D. &Schedl, H. P. (1979). British Journal of Nutrition 41, 443–454.CrossRefGoogle Scholar