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Glutathione deficiency and peripheral metabolism of thyroid hormones during dietary cysteine deprivation in rats

Published online by Cambridge University Press:  09 March 2007

C. Suberville ,
P. Higueret ,
D. Taruoura ,
H. Garcin  and
D. Higueret
C. Suberville
Affiliation:
Laboratoire Physiologie de la Nutrition, Département Alimentation et Nutrition, Université de Bordeaux I, avenue des Facultés, 33405 Talence-Cédex, France
P. Higueret
Affiliation:
Laboratoire Physiologie de la Nutrition, Département Alimentation et Nutrition, Université de Bordeaux I, avenue des Facultés, 33405 Talence-Cédex, France
D. Taruoura
Affiliation:
Laboratoire Physiologie de la Nutrition, Département Alimentation et Nutrition, Université de Bordeaux I, avenue des Facultés, 33405 Talence-Cédex, France
H. Garcin
Affiliation:
Laboratoire Physiologie de la Nutrition, Département Alimentation et Nutrition, Université de Bordeaux I, avenue des Facultés, 33405 Talence-Cédex, France
D. Higueret
Affiliation:
Laboratoire Biochimie Médicale, Hôpital Pellegrin, Place Raba Léon, 33000 Bordeaux, France
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Abstract

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1. For a period of 24 d, young rats received a diet containing 120 g casein/kg or the same basic diet supplemented with 1·93 g cysteine/kg.

2. The thyroxine (T4) turnover was decreased in rats receiving the cysteine-deficient diet compared with that of rats on the supplemented diet. Moreover, the extrathyroidal T4 pool and T4 disposal rate decreased.

3. Cysteine deprivation also decreased the peripheral metabolism of 3,5,3'-triiodothyronine (T3). The T3 distribution space, extrathyroidal pool of T3 and T3 disposal rate were diminished.

4. In vitro, deiodination of T4 in liver homogenate assayed with endogenous glutathione (GSH) demonstrated decreased T3 production rates in the case of cysteine deficiency. This difference was minimized by the addition of GSH in amounts sufficient to saturate the reaction kinetics. In the light of this finding, GSH is probably involved in the promotion of certain thyroidal problems induced by a cysteine-deficient diet.

Type
Research Article
Information
British Journal of Nutrition , Volume 59 , Issue 3 , May 1988 , pp. 451 - 456
Copyright
Copyright © The Nutrition Society 1988

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