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Flavonoid intake and the risk of ischaemic stroke and CVD mortality in middle-aged Finnish men: the Kuopio Ischaemic Heart Disease Risk Factor Study

  • Jaakko Mursu (a1), Sari Voutilainen (a1), Tarja Nurmi (a1), Tomi-Pekka Tuomainen (a1), Sudhir Kurl (a1) and Jukka T. Salonen (a1) (a2)...

Abstract

The role of flavonoids in CVD, especially in strokes, is unclear. Our aim was to study the role of flavonoids in CVD. We studied the association between the intakes of five subclasses (flavonols, flavones, flavanones, flavan-3-ols and anthocyanidins), a total of twenty-six flavonoids, on the risk of ischaemic stroke and CVD mortality. The study population consisted of 1950 eastern Finnish men aged 42–60 years free of prior CHD or stroke as part of the prospective population-based Kuopio Ischaemic Heart Disease Risk Factor Study. During an average follow-up time of 15·2 years, 102 ischaemic strokes and 153 CVD deaths occurred. In the Cox proportional hazards model adjusted for age and examination years, BMI, systolic blood pressure, hypertension medication, serum HDL- and LDL-cholesterol, serum TAG, maximal oxygen uptake, smoking, family history of CVD, diabetes, alcohol intake, energy-adjusted intake of folate, vitamin E, total fat and saturated fat intake (percentage of energy), men in the highest quartile of flavonol and flavan-3-ol intakes had a relative risk of 0·55 (95 % CI 0·31, 0·99) and 0·59 (95 % CI 0·30, 1·14) for ischaemic stroke, respectively, as compared with the lowest quartile. After multivariate adjustment, the relative risk for CVD death in the highest quartile of flavanone and flavone intakes were 0·54 (95 % CI 0·32, 0·92) and 0·65 (95 % CI 0·40, 1·05), respectively. The present results suggest that high intakes of flavonoids may be associated with decreased risk of ischaemic stroke and possibly with reduced CVD mortality.

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Corresponding author

*Corresponding author: Dr Jaakko Mursu, fax +358 17 162936, email jaakko.mursu@uku.fi

References

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1Ness, AR & Powles, JW (1997) Fruit and vegetables, and cardiovascular disease: a review. Int J Epidemiol 26, 113.
2Bravo, L (1998) Polyphenols: chemistry, dietary sources, metabolism, and nutritional significance. Nutr Rev 56, 317333.
3Geleijnse, JM, Launer, LJ, Van der Kuip, DA, Hofman, A & Witteman, JC (2002) Inverse association of tea and flavonoid intakes with incident myocardial infarction: the Rotterdam Study. Am J Clin Nutr 75, 880886.
4Hertog, M, Sweetnam, P, Fehily, AM, Elwood, PC & Kromhout, D (1997) Antioxidant flavonols and ischemic heart disease in Welsh population of men: the Caerphilly study. Am J Clin Nutr 65, 14891494.
5Hertog, MG, Feskens, EJ & Kromhout, D (1997) Antioxidant flavonols and coronary heart disease risk. Lancet 349, 699.
6Hertog, MGL, Feskens, EJM, Hollman, PCH, Katan, MB & Kromhout, D (1993) Dietary antioxidant flavonoids and risk of coronary heart disease: the Zutphen elderly study. Lancet 342, 10071011.
7Knekt, P, Järvinen, R, Reunanen, A & Maatela, J (1996) Flavonoid intake and coronary mortality in Finland: a cohort study. Br Med J 312, 478481.
8Youchum, L, Kushi, LH, Meyer, K & Folsom, AR (1999) Dietary flavonoid intake and risk of cardiovascular disease in postmenopausal women. Am J Epidemiol 149, 943949.
9Hirvonen, T, Pietinen, P, Virtanen, MM-LO, Häkkinen, S, Albanes, D & Virtamo, J (2001) Intake of flavonols and flavones and risk of coronary heart disease in male smokers. Epidemiology 12, 6267.
10Arts, IC, Jacobs, DRJ, Harnack, LJ, Gross, M & Folsom, AR (2001) Dietary catechins in relation to coronary heart disease death among postmenopausal women. Epidemiology 12, 668675.
11Arts, IC, Hollman, PC, Feskens, EJ, Bueno de Mesquita, HB & Kromhout, D (2001) Catechin intake might explain the inverse relation between tea consumption and ischemic heart disease: the Zutphen Elderly Study. Am J Clin Nutr 74, 227232.
12Knekt, P, Kumpulainen, J, Jarvinen, R, Rissanen, H, Heliovaara, M, Reunanen, A, Hakulinen, T & Aromaa, A (2002) Flavonoid intake and risk of chronic diseases. Am J Clin Nutr 76, 560568.
13Sesso, HD, Gaziano, JM, Liu, S & Buring, JE (2003) Flavonoid intake and the risk of cardiovascular disease in women. Am J Clin Nutr 77, 14001408.
14Rimm, E, Katan, M, Ascherio, A, Stampfer, MJ & Willet, WC (1996) Relation between intake of flavonoids and risk of coronary heart disease in male health professionals. Ann Intern Med 125, 384389.
15Huxley, RR & Neil, HA (2003) The relation between dietary flavonol intake and coronary heart disease mortality: a meta-analysis of prospective cohort studies. Eur J Clin Nutr 57, 904908.
16Mink, PJ, Scrafford, CG, Barraj, LM, Harnack, L, Hong, CP, Nettleton, JA & Jacobs, DRJ (2007) Flavonoid intake and cardiovascular disease mortality: a prospective study in postmenopausal women. Am J Clin Nutr 85, 895909.
17Keli, SO, Hertog, MGL, Feskens, EJM & Kromhout, D (1996) Dietary flavonoids, antioxidant vitamins and incidence of stroke. Arch Intern Med 154, 637642.
18Hirvonen, T, Virtamo, J, Korhonen, P, Albanes, D & Pietinen, P (2000) Intake of flavonoids, carotenoids, vitamins C and E, and risk of stroke in male smokers. Stroke 31, 23012306.
19Dwyer, J & Peterson, JJ (2002) Measuring flavonoid intake: need for advanced tools. Public Health Nutr 5, 925930.
20US Department of Agriculture (2003) USDA database for the flavonoid content of selected foods. http://www.nal.usda.gov (accessed 12 August 2006).
21Salonen, JT (1988) Is there continuing need for longitudinal epidemiological research? The Kuopio Ischaemic Heart Disease Risk Factor Study. Ann Clin Res 20, 4650.
22Lakka, TA, Laukkanen, JA, Rauramaa, R, Salonen, R, Lakka, H-M, Kaplan, GA & Salonen, JT (2001) Cardiorespiratory fitness and the progression of carotid atherosclerosis in middle-aged men. Ann Intern Med 134, 1220.
23Tunstall-Pedoe, H, Kuulasmaa, K, Amouyel, p, Arveiler, D, Rajakangas, AM & Pajak, A (1994) Myocardial infarction and coronary deaths in the World Health Organization MONICA Project. Registration procedures, event rates, and case-fatality rates in 38 populations from 21 countries in four continents. Circulation 90, 583612.
24Tuomilehto, J, Rastenyte, D, Sivenius, J, et al. (1996) Ten-year trends in stroke incidence and mortality in the FINMONICA Stroke Study. Stroke 27, 825832.
25Kurl, S, Laukkanen, JA, Niskanen, L, Rauramaa, R, Tuomainen, TP, Sivenius, J & Salonen, JT (2005) Cardiac power during exercise and the risk of stroke in men. Stroke 36, 820824.
26Willet, W & Stampfer, M (1998) Implications of total energy intake for epidemiologic analyses. In Nutritional Epidemiology, pp. 273301 [Willet, W, editor]. New York: Oxford University Press.
27Hodgson, JM, Burke, V & Puddey, IB (2005) Acute effects of tea on fasting and postprandial vascular function and blood pressure in humans. J Hypertens 23, 4754.
28Vlachopoulos, C, Aznaouridis, K, Alexopoulos, N, Economou, E, Andreadou, I & Stefanadis, C (2005) Effect of dark chocolate on arterial function in healthy individuals. Am J Hypertens 18, 785791.
29Hayek, T, Furhman, B, Vaya, J, Rosenblat, M, Belinky, P, Coleman, R, Elis, A & Aviram, M (1997) Reduced progression of atherosclerosis in apolipoprotein E-deficient mice following consumption of red wine, or its polyphenols quercetin or catechin, is associated with reduced susceptibility of LDL to oxidation aggregation. Arterioscler Thromb Vasc Biol 17, 27442752.
30Fuhrman, B, Volkova, N, Coleman, R & Aviram, M (2005) Grape powder polyphenols attenuate atherosclerosis development in apolipoprotein E deficient (E0) mice and reduce macrophage atherogenicity. J Nutr 135, 722728.
31Williamson, G & Manach, C (2005) Bioavailability and bioefficacy of polyphenols in humans. II. Review of 93 intervention studies. Am J Clin Nutr 81, 243255.

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Flavonoid intake and the risk of ischaemic stroke and CVD mortality in middle-aged Finnish men: the Kuopio Ischaemic Heart Disease Risk Factor Study

  • Jaakko Mursu (a1), Sari Voutilainen (a1), Tarja Nurmi (a1), Tomi-Pekka Tuomainen (a1), Sudhir Kurl (a1) and Jukka T. Salonen (a1) (a2)...

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